Electric Literature of 14531-55-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
DIAD (837muIota_, 4.25mmol) was added to a solution of 3-methyl-4-nit.ro- 1 H-pyrazole (500mg, 3.54mmol), /V-methyl-4-piperidinol (408mg, 3.54mmol) and triphenylphosphine (860mg, 4.25mmol) in THF (25ml_). The reaction mixture was stirred at rt for 5 days. The mixture was cone, in vacuo before purification by flash chromatography on silica, washing with DCM, then 30%, 70%, 100% EtOAc/DCM mixtures. The product was eluted with 5%, 10% then 20% MeOH/DCM to give the title compound as an off-white crystalline solid (289mg, 34%). LCMS (Method 1 ) Rt 2.721 min, ESIMS m/z [M+H]+ 239.3.
The synthetic route of 3,5-Dimethyl-4-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.