Category: pyrazoles-derivatives

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C5H6N2O

S3, the step S2 product 1-methyl-1H-pyrazole-5-carbaldehyde 130g was added to 1100ml of pyridine,An additional 10 ml of piperidine,140g malonic acid,Then warmed to 70 degrees Celsius, the reaction 0.5h,Then keep the temperature reflux 3h,After the cooling step, all the pyridine was evaporated under reduced pressure, 200 ml of ethanol was added,Precipitated solid, the precipitated solid was suction filtered and dried,The product of S3 step 3- (1-methyl-1H-pyrazol-5-yl) acrylic acid was obtained as a solid at room temperature.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151521-49-2, name is 4-Isopropyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H11N3

To a chilled solution of 4-isopropyl-1 H-pyrazol-5-amine (2.5 g, 20 mmol) in 20 ml DCM ethoxycarbonyl isothiocyanate (2.6 g, 20 mmol) dissolved in 10 ml DCM were added dropwise. The resulting suspension was further diluted with 30 ml DCM and stirred for 2 h. The product was collected, washed with DCM and dried. 2.0 g (7.8 mmol) of this raw material together with 3.2 g (23.4 mmol) were then refluxed in 15 ml MeCN for 2 h. After careful neutralization with acetic acid the solvent was removed in vacuo. The remaining solid was suspended in water. The product was collected, washed with water and dried to yield title compound (II) as colorless powder. 1 H-NMR (400MHz, d6-DMSO, 300K) delta 1 .14 (d, J = 6.8 Hz, 6H), 3.12 (h, J = 6.8 Hz, 1 H), 7.88 (s, 1 H), 12.60 (s, broad, 1 H), 13.34 (s, broad, 1 H); MS (ES) C8H10N4OS, requires 210.06, found 21 1 .3 (M+H)+.

According to the analysis of related databases, 151521-49-2, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89088-55-1, name is 5-Bromo-1-methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Bromo-1-methyl-1H-pyrazol-3-amine

To a solution of compound 45-3 (190 mg, 624.3 umol) in DCM (6.0 mL) was added DIEA (121 mg, 936.5 umol, 163.6 uL). The mixture was cooled to -20C for 0.5 h and then added bis(trichloromethyl) carbonate (61 mg, 206.0 umol) quickly avoiding water. The mixture was stirred at -20C for 0.5 h, and 5-bromo-l-methyl-lH-pyrazol-3-amine (109 mg, 624.3 umol) in DCM (4.0 mL) was added dropwise. The resulting mixture was stirred at 25C for 12 h and concentrated. The residue was purified by column chromatography (Si02) to afford compound 45-4 (62 mg).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 31230-17-8

General procedure: In a one neck round bottom flask placed, taken 3-substituted-1H-pyrazol-5-amine (1eq) in dichloromethane and added 4N KOH (8eqin water). The reaction mixture was allowed to stir at room temperature followed by addition ofBocanhydride (1.2eq) in small batches. The reaction mixture was allowed to stir for 3h and reaction completion was monitored by thin layer chromatography (1:1 hexane: ethyl acetate). The reaction mixture was diluted in CH2Cl2, washed brine and dried with MgSO4. The crude product was purified using silica gel column chromatography.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31230-17-8.

Related Products of 3920-40-9, The chemical industry reduces the impact on the environment during synthesis 3920-40-9, name is 4-Amino-1-methyl-1H-pyrazole-3-carboxamide, I believe this compound will play a more active role in future production and life.

A mixture of 2-bromothiazole-4-carboxylic acid (891 mg), 4-amino-1-methyl-1H-pyrazole-3-carboxamide (600 mg) and HATU (1.95 g) in DMF (5 ml) and ethyldiisopropylamine (1.5 ml) is stirred at room temperature for 20 h and then poured into ice-water. The precipitated solid is filtered off, washed twice with water and three times each with diethyl ether and ethyl acetate and dried in vacuo (889 mg).C9H8BrN5O2S (329.0), LC-MS (ZQ): Rt=0.87, m/z=330 [M+H]+. 1H-NMR (300 MHz, D6-DMSO): 3.88 (s, 3H), 7.45 (br. s., 1H), 7.70 (br. s., 1H), 8.31 (s, 1H), 8.41 (s, 1H), 11.0 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-1-methyl-1H-pyrazole-3-carboxamide, other downstream synthetic routes, hurry up and to see.

Related Products of 4522-35-4,Some common heterocyclic compound, 4522-35-4, name is 3-Iodo-1H-pyrazole, molecular formula is C3H3IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a soluton of3-iodopyrazole (500 mg, 2.58mmol) and 3,5-dichloropyridazine(384 mg, 2.58 mmol) in anhydrous DMF (5 mL) at room temperature was addedpotassium tert-butoxide (289 mg, 2.58 mmol) in one portion. It was heated at100 C for 1 h. It was cooled to room temperature, diluted with EtOAc (50 mL),washed with satd aq. NaHC03 (10 mL) and water (100 mL). The aqueous layerwas separated and extracted with EtOAc (3 x 50 mL). The combined organiclayers were washed with water (1 00 mL), brine (1 00 mL), dried over Na2S04,filtered and concentrated. The residue was purified by flash chromatography(ISCO Combiflash, Gold 40 g, 0-60% EtOAc in hexanes) to give 3-chloro-5-(3-iodo-1H-pyrazol-1-yl)pyridazine, as a white solid. LCMS calc.= 306.92, found= 306.96 (M+Ht. 1H NMR (500 MHz, CHCh-d): o 9.54 (d, J= 2.3 Hz, 1 H);7.94 (d, J= 2.7 Hz, 1 H); 7.90 (d, J= 2.3 Hz, 1 H); 6.81 (d, J= 2.7 Hz, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Iodo-1H-pyrazole, its application will become more common.

Synthetic Route of 876343-24-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 876343-24-7 as follows.

Example 17 A solution of the aminopyrazole (0.28 g, 2.5 mmol) and the dibromopyrazinone (0.74 g, 1.1 equiv) were heated to 120¡ã C. in isopropanol for 1 h. The reaction mixture was cooled to RT, and the product was isolated by filtration (0.43 g, 57percent).

According to the analysis of related databases, 876343-24-7, the application of this compound in the production field has become more and more popular.

Application of 1572-10-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-10-7, name is 3-Amino-5-phenylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of beta-bromovinyl aldehyde 1 (1.0 mmol), aminopyrazole 2 (1.0 mmol), Pd(OAc)2 (5mol%), PPh3 (10 mol%) and K2CO3(1.2 mmol) in DMF (1.0 mL) was irradiated in a closed vessel in a Synthos 3000 microwave reactor at 700 Watt (120 oC and 14 bar) for 20 minutes. After completion of the reaction, the reaction mixture was treated with water (30 mL) and then extracted with ethylacetate (30 x 3 mL). The organic portion was washed with water, dried over anhydrous sodium sulfate and the solvent was removed in vacuo to obtain a crude product which on silica gel column chromatographic purification using EtOAc/hexane as the eluent afforded compounds 3a-l.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-5-phenylpyrazole. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 852443-61-9 as follows. SDS of cas: 852443-61-9

Step C. Using a microwave, a mixture of the title compound from Step B above (150 mg) and commercially available methyl acetopyruvate (150 mg) in MeOH (1 mL) in a sealed vial was heated at 120C for 12 min, concentrated and purified by chromatography (silica, CH2Cl2) to give 7-methyl-2-trifluoromethyl- pyrazolo[l,5-a]pyrimidine-5-carboxylic acid methyl ester (0.15 g, 58%). [MH]+ = 260.

According to the analysis of related databases, 852443-61-9, the application of this compound in the production field has become more and more popular.

52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate

To a solution of [5-(4-fluoro-phenyl)-3-methyl-3H-[l,2,3]triazol-4-yl]-methanol (290 mg, 1.4 mmol) in THF (30 mL) was added 5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (218 mg, 1.4 mmol) and triphenylphosphine (477 mg, 1.82 mmol) at ambient temperature under an argon atmosphere. Then diethyl azodicarboxylate (641 mu, 3.5 mmol) was added and the reaction mixture was stirred for 16 h at room temperature. Concentration and purification by chromatography (silica, 20 to 50% ethyl acetate in heptane) afforded the title compound (483 mg, 100%) as a white solid. MS: m/e = 346.2 [M+H]+.

The synthetic route of 52867-42-2 has been constantly updated, and we look forward to future research findings.