Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C5H6N2O
S3, the step S2 product 1-methyl-1H-pyrazole-5-carbaldehyde 130g was added to 1100ml of pyridine,An additional 10 ml of piperidine,140g malonic acid,Then warmed to 70 degrees Celsius, the reaction 0.5h,Then keep the temperature reflux 3h,After the cooling step, all the pyridine was evaporated under reduced pressure, 200 ml of ethanol was added,Precipitated solid, the precipitated solid was suction filtered and dried,The product of S3 step 3- (1-methyl-1H-pyrazol-5-yl) acrylic acid was obtained as a solid at room temperature.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.