Category: 3920-40-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3920-40-9, name is 4-Amino-1-methyl-1H-pyrazole-3-carboxamide, A new synthetic method of this compound is introduced below., COA of Formula: C5H8N4O

Stage c A mixture of 2-(3-methanesulphonylphenyl)thiazole-4-carboxylic acid (120 mg) from stage b and 4-amino-1-methyl-1H-pyrazole-3-carboxamide (65 mg) in triethylamine (176 muL) and DMF (3 ml) in the presence of HATU (209 mg) is stirred at room temperature for 88 h. Water is added, the mixture is extracted with ethyl acetate and the organic phase is concentrated. Purification by preparative HPLC and purification by column chromatography on silica gel (mobile phase cyclohexane/acetone) result in 2-(3-methanesulphonylphenyl)thiazole-4-(3-carbamoyl-1-methyl-1H-pyrazol-4-yl)carboxamide (3.4 mg) as a white solid. C16H15N5O4S2, M=405.1; LC-MS (ZQ): Rt=0.92, m/z=406 [M+H]+. 1H-NMR (300 MHz, D6-DMSO): 3.31 (s, 3H), 3.90 (s, 3H), 7.56 (s, 1H), 7.72 (s, 1H), 7.84 (m, 1H), 8.07 (m, 1H), 8.32-8.38 (m, 2H), 8.43 (m, 1H), 8.55 (s, 1H), 11.3 (s, 1H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Ulrich, BOTHE; Arne, Von Bonin; Duy, Nguyen; Ulf, Bomer; Judith, Guenther; US2009/163486; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 3920-40-9, The chemical industry reduces the impact on the environment during synthesis 3920-40-9, name is 4-Amino-1-methyl-1H-pyrazole-3-carboxamide, I believe this compound will play a more active role in future production and life.

A mixture of 2-bromothiazole-4-carboxylic acid (891 mg), 4-amino-1-methyl-1H-pyrazole-3-carboxamide (600 mg) and HATU (1.95 g) in DMF (5 ml) and ethyldiisopropylamine (1.5 ml) is stirred at room temperature for 20 h and then poured into ice-water. The precipitated solid is filtered off, washed twice with water and three times each with diethyl ether and ethyl acetate and dried in vacuo (889 mg).C9H8BrN5O2S (329.0), LC-MS (ZQ): Rt=0.87, m/z=330 [M+H]+. 1H-NMR (300 MHz, D6-DMSO): 3.88 (s, 3H), 7.45 (br. s., 1H), 7.70 (br. s., 1H), 8.31 (s, 1H), 8.41 (s, 1H), 11.0 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-1-methyl-1H-pyrazole-3-carboxamide, other downstream synthetic routes, hurry up and to see.