In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 852443-61-9 as follows. SDS of cas: 852443-61-9
Step C. Using a microwave, a mixture of the title compound from Step B above (150 mg) and commercially available methyl acetopyruvate (150 mg) in MeOH (1 mL) in a sealed vial was heated at 120C for 12 min, concentrated and purified by chromatography (silica, CH2Cl2) to give 7-methyl-2-trifluoromethyl- pyrazolo[l,5-a]pyrimidine-5-carboxylic acid methyl ester (0.15 g, 58%). [MH]+ = 260.
According to the analysis of related databases, 852443-61-9, the application of this compound in the production field has become more and more popular.