Category: pyrazoles-derivatives

Adding a certain compound to certain chemical reactions, such as: 56430-08-1, name is 1,5-Dimethyl-2-(p-tolyl)-1H-pyrazol-3(2H)-one, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56430-08-1, SDS of cas: 56430-08-1

General procedure: The mixture of isatin 1 (58.9 mg, 0.4 mmol), antipyrine 2 (37.6 mg, 0.2 mmol) andimidazole (20 mol %, 0.04 mmol) in 1 mL H2O were stirred at 80 . Once thereaction completed, the solid mixture was filtered, washed by water and dried undervacuum to afford the analytically pure products 3. In some cases, the desired pureproducts were obtained by silica gel chromatography using ethyl acetate as eluent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Dimethyl-2-(p-tolyl)-1H-pyrazol-3(2H)-one, other downstream synthetic routes, hurry up and to see.

Application of 2075-46-9,Some common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Preparation of 1-benzyl-4-nitro-pyrazole To a stirred solution of 4-nitro-1H-pyrazole (2.00 g, 17.7 mmol) in N,N-dimethylformamide (15 mL) was added sodium hydride (0.778 g, 19.0 mmol, 60% purity in mineral oil) at 0 C. The reaction mixture was stirred at 15 C. for 1 h and then cooled to 0 C. before benzyl bromide (2.10 mL, 17.7 mmol) was added. The reaction mixture was warmed to 15 C. and stirred for 15 h then quenched by adding ice water (5 mL) and extracted with ethyl acetate (15 mL*3). The combined organic layers were washed with water (10 mL*2) and brine (5 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (ISCO, 20 g silica, 0-30% ethyl acetate in petroleum ether, gradient over 20 min) to give 1-benzyl-4-nitro-pyrazole (2.80 g, 13.8 mmol, 78%) as a white solid. 1H NMR (400 MHz, Chloroform-d) delta 8.10 (s, 1H), 8.04 (s, 1H), 7.45-7.39 (m, 3H), 7.32-7.28 (m, 2H), 5.31 (s, 2H); LCMS (ESI) m/z: 204.1 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitro-1H-pyrazole, its application will become more common.

Electric Literature of 4522-35-4, These common heterocyclic compound, 4522-35-4, name is 3-Iodo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

INTERMEDIATE 23 Methyl 4-(3-iodo- lH-pyrazol- 1 -yl)picolinate To 3-iodo-lH-pyrazole (625 mg, 3.22 mmol) in DMSO (15 mL) at 0 C,was added sodium hydride (60% in mineral oil, 155 mg, 3.87 mmol). The reaction was stirred for 30 min before methyl 4-fluoropicolinate (500 mg, 3.22 mmol) was added and the reaction was stirred at 90 C for 4.5 h. The reaction mixture was quenched by the addition of water and the mixture was extracted with EtOAc. The combined organic extracts were dried over MgS04 and concentrated in vacuo. The crude mixture was purified by flash chromatography (ISCO Combiflash, 0-100%) EtOAc in hexanes) to afford methyl 4-(3-iodo-lH-pyrazol-l-yl)picolinate, as a colorless solid. LCMS calc. = 329.97; found = 329.88 (M+H)+.

Statistics shows that 3-Iodo-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 4522-35-4.

151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-Bromo-1-methyl-1H-pyrazole

0583-1 A suspension of 5-bromothiazole (200 mg), bis(pinacolato)diboron (371 mg), (1,1′-bis(diphenylphosphino)ferrocene)palladium(II) dichloride (98 mg) and potassium acetate (296 mg) in 1,4-dioxane (6 mL) was stirred at 100 C. for 2 hours in a nitrogen atmosphere. 3-Bromo-1-methyl-1H-pyrazole (194 mg), water (0.6 mL), sodium carbonate (320 mg), and bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) (42 mg) were added to the reaction mixture, followed by stirring at 100 C. for 2 hours. The reaction mixture was cooled to room temperature, the insolubles were filtered off, and the obtained residue was purified by silica gel column chromatography (methanol-ethyl acetate), thereby obtaining 5-(1-methyl-1H-pyrazol-3-yl)thiazole (16 mg). MS m/z (M+H): 166.

The synthetic route of 151049-87-5 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1151814-36-6, name is 1-Cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1151814-36-6, Computed Properties of C6H8N2

To a solution of crude 1 -cyclopropyl- lH-pyrazole (108 mg, 1.00 mmol) in CEtaCI3 (4 mL) at room temperature was added Br2 (51 uL, 1.0 mmol) via syringe. The orange solution was stirred for 1 h. The reaction was diluted with saturated aqueous Na2S2O3 (3 mL) and saturated aqueous NaHCO3 (3 mL). The mixture was extracted with CH2Cl2 (3 x 5 mL). The combined organic layers were dried over Na2Stheta4 and concentrated on a rotary evaporator without heating the sample to give 4-bromo-l -cyclopropyl- lH-pyrazole as a volatile, light yellow liquid that was used without further purification, m/z 187.3 [M + H]+.

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Product Details of 96799-02-9

To a solution of compound 2 (300 mg, 0.88 mmol) in THF (5 mL) a solution of 3- amino-5-92-furyl)pyrazole (105 mg, 0.70 mmol) and DIPEA (0.16 mL, 0.88 mmol) was added in 10-20 mL microwave vial. Vial was sealed with a cap and the mixture was allowed to stir at 150 0C for 5 minutes in the microwave synthesizer. Next, 1 -methyl piperazine (0.15 mL, 1.32 mmol) and DIPEA (0.23 mL, 1.32 mmol) were added to the above mixture and allowed to stir at 60 0C for 10 min. in the microwave synthesizer. The solvents were evaporated and the residue was chromatographed on a silica gel column eluted with 0-5 % MeOH/DCM obtaining compound 5 as off white solid (120 mg, 26 %). 1H NMR (400 MHz, DMSOd6) 5 12.66 (bs, IH, NH), 10.37 (s, IH, NH), 9.79 (s, IH, NH), 7.71 (bs, 3H; Ar-H), 7.51 (d, J = 8.4 Hz, IH, Ar-H), 6.07-6.01 (bs, IH, Ar-H), 3.70 (bs, 4H, 2CH2), 2.33 (m, 4H, 2CH2), 2.20 (s, 3H, CH3), 1.85-1.78 (m, IH, CH), 1.84-1.82 (m, 4H, Ar-H); ESI-MS: calculated for (C25H27N9OS2) 517, found 518 [M+H]+. HPLC: retention time: 17.10 min. purity: 100%.

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 25016-20-0

Step 1: Preparation ofmethyl 1-methyl-JH-pyrazole-3-carboxylate. To a solution of i-methyl1H-pyrazole-3-carboxylic acid (504 mg, 4 mmol) in MeOH (5 mL) was added SOC12 (1.4 mL, 20 mmol) at 0C. The mixture was stirred at r.t overnight then concentrated under reduced pressure. The residue was dissolved in EtOAc, washed withsatd. aq. NaHCO3and concentrated to afford methyl 1 -methyl-1H-pyrazole-3-carboxylate.LC-MS: m/z 141 (M+H).

The synthetic route of 1-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Electric Literature of 1780-72-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1780-72-9 as follows.

General procedure: To a mixture of 1-aryl-3-ethoxy-2-(phenylsulfonyl)prop-2-en-1-one 3refPreviewPlaceHolder[28] (10 mmol) and appropriate aminopyrazole derivative 2 (10 mmol) in absolute EtOH (25 mL) were added few drops of piperidine and the reaction mixture was refluxed for 1 h, then left to cool. The formed solid product was filtered off, washed with ethanol and recrystallized from EtOH/DMF to afford products identical in all respects (mp, mixed mp and spectra) with those obtained by refPreviewPlaceHolderMethod A above.

According to the analysis of related databases, 1780-72-9, the application of this compound in the production field has become more and more popular.

Synthetic Route of 34091-51-5,Some common heterocyclic compound, 34091-51-5, name is 5-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A deoxygenated mixture of 2- (4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl) -1H-indole (100 mg, 0.411 mmol) , 5-iodo-1-methyl-1H-pyrazole (860 mg, 0.411 mmol) , bis (triphenylphosphine) palladium (II) chloride (14 mg, 0.021 mmol) , and aqueous sodium carbonate solution (0.620 mL, 2M) in dioxane (2 mL) was heated under microwave irradiation at 120 for 30 minutes. The reaction mixture was cooled, diluted with EtOAc (5 mL) , filtered and concentrated. The residue was purified by column chromatography on silica gel (0-50EtOAc in hexanes) to afford the title compound. MS: m/z 198.1 (M + 1) .

The synthetic route of 34091-51-5 has been constantly updated, and we look forward to future research findings.

Reference of 1280210-79-8, The chemical industry reduces the impact on the environment during synthesis 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, I believe this compound will play a more active role in future production and life.

under nitrogen protection, intermediate 2(1000 mg, 4.78mmol) is dissolved in N, N – (15 ml) in dimethyl formamide, lowering the temperature to -15 C, adding double (trimethyl xi) sodamide (4.78 ml, 2 mol/L, 9.56mmol), stirring 30 minutes, dropping S – cyclopentyl sulphur acyl radicals (1.37g, 8.13mmol), keep the -15 C reaction 16 hours. The end of the reaction, raising the temperature to 0 C, adding water to the reaction solution (20 ml) quenching the reaction, ethyl acetate (20mL × 2) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated. Re-dissolved in tetrahydrofuran (20 ml) in, cooling to -10 C to 0 C, adding 3rd butanol potassium (85 mg, 0.76mmol), this temperature is kept under 24 hours reaction. The end of the reaction, by adding saturated ammonium chloride solution (10 ml), water (10 ml), ethyl acetate (20mL × 3) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated. Silica gel column chromatography separation and purification of the residue (petroleum ether/ethyl acetate (v/v)=5:1), to obtain white solid6a(800 mg, yield 62%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, other downstream synthetic routes, hurry up and to see.