Reference of 1280210-79-8, The chemical industry reduces the impact on the environment during synthesis 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, I believe this compound will play a more active role in future production and life.
under nitrogen protection, intermediate 2(1000 mg, 4.78mmol) is dissolved in N, N – (15 ml) in dimethyl formamide, lowering the temperature to -15 C, adding double (trimethyl xi) sodamide (4.78 ml, 2 mol/L, 9.56mmol), stirring 30 minutes, dropping S – cyclopentyl sulphur acyl radicals (1.37g, 8.13mmol), keep the -15 C reaction 16 hours. The end of the reaction, raising the temperature to 0 C, adding water to the reaction solution (20 ml) quenching the reaction, ethyl acetate (20mL × 2) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated. Re-dissolved in tetrahydrofuran (20 ml) in, cooling to -10 C to 0 C, adding 3rd butanol potassium (85 mg, 0.76mmol), this temperature is kept under 24 hours reaction. The end of the reaction, by adding saturated ammonium chloride solution (10 ml), water (10 ml), ethyl acetate (20mL × 3) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated. Silica gel column chromatography separation and purification of the residue (petroleum ether/ethyl acetate (v/v)=5:1), to obtain white solid6a(800 mg, yield 62%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, other downstream synthetic routes, hurry up and to see.