Tag: M.W:200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C10H15N3O2

Synthesis of 244-A. To a solution of tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)- carboxylate (1.40 g, 6.70 mmol) in DCM (10 mL) was added TFA (3 mL) dropwise under ice bath. Then the solution was stirred at room temperature 1 h. The solvent was removed in vacuo to give 244- A as a crude product

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1280210-79-8.

Reference of 105486-72-4, These common heterocyclic compound, 105486-72-4, name is Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl 5-bromo-l-methylpyrazole-4-carboxylate (1.0 g, 4.29 mmol), 3- nitrophenylboronic acid (859 mg, 5.15 mmol), sodium carbonate (909 mg, 8.58 mmol dissolved in 4.3 mL water), and bis(triphenylphosphine)palladium(II) dichloride (151 mg, 0.21 mmol) in DME (43 mL) was heated to 90 C overnight. After this time, General Work-up Procedure 1 was followed, and the crude residue was purified by Chromatography A to afford the title compound (710 mg, 60 % yield).

The synthetic route of 105486-72-4 has been constantly updated, and we look forward to future research findings.

Related Products of 39806-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 4-Iodo-1-methyl-1H-pyrazole 1 (101 mg, 0.5 mmol) and phenylboronic 2 (59 mg, 0.5 mmol) were dissolved in DME (3 mL) and H2O (1.2 mL) in a microwave vial under a nitrogen atmosphere. Pd(PPh3)4 (2 mmol%, 11.6 mg) and Cs2CO3 (407.3 mg, 1.25 mmol) were added, and the reaction mixture was irradiated in a microwave apparatus at 90 C for 5-12 min. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by silica gel column chromatography using petroleum ether/acetone as eluent to give the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 30169-25-6, name is 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, A new synthetic method of this compound is introduced below., Quality Control of 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

Benzimidazole (248 mg, 2.1 mmol) was added to tetrazine 1a (270 mg, 1 mmol) in acetonitrile (5 mL), the mixture was stirred for 3 h with heating to 75 C. Then, after hot filtration, the substance was washed with hot acetonitrile on the filter. The yield was 299 mg (95%). A red powder, m.p. 332-334 C. Found (%): C, 60.74; H, 3.41; N, 35.42. C16H10N8. Calculated (%): C, 61.14; H, 3.21; N, 35.65. 1H NMR (DMSO-d6), delta: 7.48-7.55, 7.56-7.62, 7.91-7.97, 8.45-8.52 (both m, 2 H each, H(4), H(5), H(6), H(7) in benzimidazolyls); 9.43 (both s, 2 H each, H(2) in benzimidazolyls). 13C NMR (DMSO-d6), delta: it was technically impossible to register 13C NMR spectrum because of the poor solubility of compound 1d.

The synthetic route of 30169-25-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 866837-96-9, These common heterocyclic compound, 866837-96-9, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Procedure E15-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid2 g (8.65 mmol) of ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate are dissolved in 20 ml EtOH and 20 ml of 1M NaOH solution are added. The mixture is stirred overnight, the solvent removed in vacuo and the crude product subject to HPLC chromatography: Yield: 65%

The synthetic route of 866837-96-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1280210-79-8, These common heterocyclic compound, 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

under nitrogen protection, Intermediate 2(1000 mg, 4.78mmol) is dissolved in N, N – dimethyl formamide(15ml), lowering the temperature to -15 C, sodium bis(trimethylsilyl)amide (4.78 ml, 2 mol/L, 9.56mmol), was added stirring 30 minutes, will S – tetrahydrofuran -3 – sulfonyl chloride (1.39g, 8.13mmol) is added in the reaction solution, to maintain this temperature reaction is 16 hours. The end of the reaction, raising the temperature to 0 C, adding water to the reaction solution (20 ml) quenching the reaction, ethyl acetate (20mL ¡Á 2) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated, re-dissolved in tetrahydrofuran (20 ml) in, cooling to -10 C to 0 C. Adding 3rd butanol potassium (85 mg, 0.76mmol), this temperature is kept under 24 hours reaction. The end of the reaction, by adding saturated ammonium chloride solution (10 ml), water (10 ml), ethyl acetate (20mL ¡Á 3) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated. Silica gel column chromatography separation and purification of the residue (petroleum ether/ethyl acetate (v/v)=5:1), to obtain white solid5a(810 mg, 62.3% yield).

The synthetic route of 1280210-79-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1191616-45-1, The chemical industry reduces the impact on the environment during synthesis 1191616-45-1, name is 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.

Compound 11c (1.4g, 5.0mmol),1-(4-Bromophenyl)-1-methyl-1H-pyrazole(1.2g, 5.0mmol), catalyst Pd(dba)2 (144mg, 0.25mmol), tri-tert-butylphosphine (101mg, 0.5mmol), sodium tert-butoxide (576mg, 6.0mmol) were dissolved in toluene (50ml) The temperature was raised to 100C and the reaction was stirred for 12 hours. The reaction was detected by TLC, and directly concentrated by column chromatography to obtain 1.4g of off-white solid with a yield of 63.1%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 497832-99-2 as follows. HPLC of Formula: C5H4BrF3N2

[1,1 ?-bis(diphcnylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (0.64 g, 0.87 mmol) was added to a mixture of 4-bromo-1-methyl-3-(trifluoromethyl)-IH- pyrazole (2.0 g, 8.7 mmol), 2-fluoro-4-(4,4,5 ,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)aniline (2.1 g, 8.7 mmol) and Na2CO3 (1.8 g, 17.4 mmol) in 1,4-dioxane (20 mL) and water (4 mL).The reaction mixture was stirred under nitrogen atmosphere at 120 C for 12 h. After cooling to room temperature the reaction mixture was filtered, concentrated in vacuo and the residue was purified by silica gel chromatography (petroleum ether/EtOAc3:1 to 1:1) to give the title compound (1.2 g, 55%) as a light yellow solid. LCMS MIZ (M+H) 260.

According to the analysis of related databases, 497832-99-2, the application of this compound in the production field has become more and more popular.

Reference of 89607-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89607-15-8 name is 3-Bromo-1-methyl-4-nitro-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 5: Into a 100 mL round bottom flask containing a solution of 3-bromo-1-methyl-4-nitro-1H-pyrazole (1.0 g) in ethyl acetate (50 mL) at room temperature was added Raney Nickel (700mg) and the reaction mixture was stirred at room temperature for 16 h under hydrogen atmosphere. The reaction mixture was filtered through celite and washed with ethyl acetate. The filtrate was concentrated under reduced pressure and purified by flash chromatography eluting with ethyl acetate in petroleum ether (40-50%) to afford 3-bromo-1-methyl-1H-pyrazol- 4-amine as a liquid. ?H NMR (CD3OD, 400 MHz): 7.18 (s, 1H), 3.77 (s, 3H). MS calc?d[M+Hj 176.0, found 176.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-1-methyl-4-nitro-1H-pyrazole, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1146629-77-7, Recommanded Product: 1146629-77-7

To a solution of 37 (514 mg, 1.72 mmol, prepared as described in Lin, Q. et al., Org. Lett., 2009, 11, 1999-2002) in acetonitrile (15 mL) was added 44 (537 mg, 4.29 mmol).Then DBU (540 muL, 3.61 mmol) was added.The reaction was stirred at room temperature for 15 hours.It was then concentrated under reduced pressure in vacuo.The crude mixture was diluted with water and extracted with EtOAc EtOAc.Organic layer merger,Wash with 1N hydrochloric acid,Dry (Na2SO4), filtered and concentrated.Purification by normal phase column chromatography (SiO2, 0-60% ethyl acetate / hexane)(+/-) 45 (368 mg, 50%) to white foam.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, other downstream synthetic routes, hurry up and to see.