Adding a certain compound to certain chemical reactions, such as: 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1146629-77-7, Recommanded Product: 1146629-77-7
To a solution of 37 (514 mg, 1.72 mmol, prepared as described in Lin, Q. et al., Org. Lett., 2009, 11, 1999-2002) in acetonitrile (15 mL) was added 44 (537 mg, 4.29 mmol).Then DBU (540 muL, 3.61 mmol) was added.The reaction was stirred at room temperature for 15 hours.It was then concentrated under reduced pressure in vacuo.The crude mixture was diluted with water and extracted with EtOAc EtOAc.Organic layer merger,Wash with 1N hydrochloric acid,Dry (Na2SO4), filtered and concentrated.Purification by normal phase column chromatography (SiO2, 0-60% ethyl acetate / hexane)(+/-) 45 (368 mg, 50%) to white foam.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, other downstream synthetic routes, hurry up and to see.