Category: 1146629-77-7

Adding a certain compound to certain chemical reactions, such as: 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1146629-77-7, Recommanded Product: (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

To a solution (15 mL) of 37 (514 mg, 1.72 mmol, preparation described in Lin, Q. et al. Org. Lett., 2009, 11, 1999-2002) in acetonitrile was added 44 (537 mg, 4.29 mmol) , Then DBU (540 muL, 3.61 mmol) was added. The reaction was stirred at room temperature for 15 h and then concentrated under reduced pressure. The resulting crude mixture was diluted with water and extracted with ethyl acetate (3 x 50 mL). The combined organic layers were washed with 1 N HCl, dried (Na 2 SO 4), filtered and concentrated under reduced pressure. Purification by normal phase column chromatography (SiO 2, 0 to 60% ethyl acetate / hexane) gave (+/-) 45 as a white foam (368 mg, 50%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Concert Pharmaceuticals Inc.; Zhou, Haibing; Peng, Xueke; Hu, Zhiye; Ning, Wentao; Dong, Chune; (43 pag.)JP2018/172421; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 1146629-77-7,Some common heterocyclic compound, 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, molecular formula is C15H17N5O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

37 in acetonitrile (514mg, 1.72mmol, Lin, Q. et al. Org. Lett., 2009, 11, to a solution (15mL) of the is preparation) described in 1999-2002, 44 (537mg, 4.29mmol), followed by the addition of DBU (540muL, 3.61mmol). The reaction was stirred at room temperature for 15 hours, then concentrated under reduced pressure. The resulting mixture of crude was diluted with water and extracted with ethyl acetate (3 x 50mL). The combined organic layers were washed with 1N HCl, dried (Na2SO4), filtered, and concentrated in vacuo. Normal phase column chromatography (SiO 2, 0~60% ethyl acetate / hexanes) Purification on to give a white foam (+/-)-45 (368mg, 50%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, its application will become more common.

Reference:
Patent; Concert Pharmaceuticals Inc.; Ai, Robert Silverman; Julie, F. Liu; Adam, J. Morgan; Bhomick, Panda; Scott, EL. Habeson; (43 pag.)JP2015/117185; (2015); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1146629-77-7, Formula: C15H17N5O2

37 in acetonitrile (619mg, 2.07mmol, Lin, Q. et al. Org. Lett., 2009, 11, to a solution (15mL) of the is preparation) described in 1999-2002, 51 (673mg, 5.17mmol), followed by the addition of DBU (650muL, 4.35mmol). The reaction was stirred for 15 hours at room temperature, and concentrated under reduced pressure. The resulting mixture of crude was diluted with water, and extracted with ethyl acetate (3x50mL). The combined organic layers were washed with 1N HCl, dried (Na2SO4), filtered and concentrated under reduced pressure. Normal phase column chromatography (SiO2, 0~60% ethyl acetate / hexanes) Purification on to give a white foam (+/-)-52 (447mg, 50%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Concert Pharmaceuticals Inc.; Ai, Robert Silverman; Julie, F. Liu; Adam, J. Morgan; Bhomick, Panda; Scott, EL. Habeson; (43 pag.)JP2015/117185; (2015); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 1146629-77-7, The chemical industry reduces the impact on the environment during synthesis 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, I believe this compound will play a more active role in future production and life.

Add to a solution of 37 (400 mg, 1.34 mmol, prepared in Lin, Q. et al., Org. Lett., 2009, 11, 1999-2002) in acetonitrile (10 mL)36 (418 mg, 3.34 mmol),Then DBU (421 muL, 2.81 mmol) was added.The reaction was stirred at room temperature for 15 hours.It was then concentrated under reduced pressure. The crude mixture was diluted with water and extracted with EtOAc EtOAc. The organic layers were combined, washed with EtOAc EtOAc m.Purification by normal phase column chromatography (SiO2, 0-60% ethyl acetate / hexanes) and purified by reverse column chromatography (C18, 5-70% acetonitrile/water containing 0.1% formic acid) +/-) 38 (68 mg, 12%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kang Saite Pharmaceutical Pin Co., Ltd.; I ·R·xierfuman; J ·F·liu; A ·J·mogen; B ·pandeya; S ·L·habisen; (30 pag.)CN104725380; (2019); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1146629-77-7, Formula: C15H17N5O2

To a solution (15 mL) of 37 (514 mg, 1.72 mmol, preparation described in Lin, Q. et al. Org. Lett., 2009, 11, 1999-2002) in acetonitrile was added 44 (537 mg, 4.29 mmol) , Then DBU (540 muL, 3.61 mmol) was added. The reaction was stirred at room temperature for 15 h and then concentrated under reduced pressure. The resulting crude mixture was diluted with water and extracted with ethyl acetate (3 x 50 mL). The combined organic layers were washed with 1 N HCl, dried (Na 2 SO 4), filtered and concentrated under reduced pressure. Purification by normal phase column chromatography (SiO 2, 0 to 60% ethyl acetate / hexane) gave (+/-) 45 as a white foam (368 mg, 50%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Concert Pharmaceuticals Inc.; Zhou, Haibing; Peng, Xueke; Hu, Zhiye; Ning, Wentao; Dong, Chune; (43 pag.)JP2018/172421; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, A new synthetic method of this compound is introduced below., SDS of cas: 1146629-77-7

Method B.; To a stirred suspension of [4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate (19, 158 mg, 0.50 mmol) and 3-cyclopentylacrylonitrile (8, 122 mg, 1.0 mmol, 2.0 equiv) in dimethyl sulfoxide (DMSO, 1.0 mL, 14 mmol) at room temperature was added powder potassium carbonate (K2CO3, 10.4 mg, 0.075 mmol, 0.15 equiv). The reaction mixture was then stirred at room temperature for 5 h. The reaction mixture became a clear solution in 2 h. When LCMS showed the reaction was deemed complete, the reaction was quenched with water (H2O, 5 mL) and extracted with ethyl acetate (EtOAc, 3×15 mL). The combined organic extracts were washed with saturated aqueous NaCl solution (10 mL), dried over magnesium sulfate (MgSO4), and concentrated under reduced pressure. The residue was then purified by flash chromatography (SiO2, 0-50% EtOAc/hexanes gradient elution) to afford racemic (4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate (20, 172.6 mg, 210 mg theoretical, 82% yield) as a white solid. For 20: 1H NMR (CDCl3, 400 MHz) delta ppm 8.87 (s, 1H), 8.30 (s, 1H), 8.29 (s, 1H), 7.47 (d, 1H, J=3.9 Hz), 6.75 (d, 1H, J=3.9 Hz), 6.24 (s, 2H), 4.25 (m, 1H), 3.12 (dd, 1H, J=17.0, 8.7 Hz), 2.95 (dd, 1H, J=17.0, 3.9 Hz), 2.58 (m, 1H), 1.95 (m, 1H), 1.72-1.52 (m, 5H), 1.25 (m, 2H), 1.14 (s, 9H); C23H28N6O2 (MW, 420.51), LCMS (EI) m/e 421.4 (M++H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1146629-77-7

4-(1-(2-Cyano-1-cyclopentylvinyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate (9).; To a 500 mL round bottom flask equipped with a stir bar and the nitrogen inlet was charged 3-cyclopentylpropiolonitrile (8, 8.50 g, 0.0713 mol, 1.52 equiv), N,N-dimethylformamide (DMF, 84 mL, 1.08 mol) and [4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate (5, 14.0 g, 0.0468 mol) and solid potassium carbonate (K2CO3, 0.329 g, 0.00238 mol, 0.05 equiv) at room temperature. The resulting reaction mixture was then stirred at room temperature for 60 min. When TLC and HPLC showed that the reaction was deemed complete, the reaction mixture was quenched with 20% aqueous brine (75 mL) and the resulting solution was extracted with ethyl acetate (EtOAc, 3¡Á75 mL). The combined organic extracts were washed with 20% aqueous brine (75 mL), dried over magnesium sulfate (MgSO4), filtered, and concentrated under reduced pressure. The residue was purified by flash chromatography (SiO2, 0 to 20% ethyl acetate/hexane gradient elution) to afford 4-(1-(2-cyano-1-cyclopentylvinyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate (9, 16.4 g, 19.6 g theoretical, 83.7% yield) as white solids. For 9: 1H NMR (DMSO-d6, 300 MHz) delta 9.09 (s, 1H), 8.84 (s, 1H), 8.63 (s, 1H), 7.78 (d, 1H, J=3.8 Hz), 7.17 (d, 1H, J=3.8 Hz), 6.24 (s, 2H), 5.82 (s, 1H), 3.55 (m, 1H), 1.92 (m, 2H), 1.59 (br m, 6H), 1.06 (s, 9H); C23H26N6O2 (MW, 418.49), LCMS (EI) m/e 419 (M++H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1146629-77-7.

Some common heterocyclic compound, 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, molecular formula is C15H17N5O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C15H17N5O2

Step 6. (+/-)-(4-(1 -(2-Cyano- 1 -(2,2,5,5 -d4-cyclopentyl)ethyl)- 1 H-pyrazol-4- yl)-7H-pyrrolol2,3-dlpyrimidin-7-yl)methyl pivalate ((+/-)38). To a solution of 37 (400 mg, 1.34 mmol, preparation described in Lin, Q. et al. Org. Lett., 2009, 1], 1999-2002) in acetonitrile (10 mL) was added 36 (418 mg, 3.34 mmol) followed by DBU (421 tL, 2.81 mmol). The reaction stirred at room temperature for 15 hours then was concentrated under reduced vacuum. The resulting crude mixture was diluted with water and extracted with ethyl acetate (3 x 50 mL). The organic layers were combined, washed with iN HC1, dried (Na2SO4), filtered and concentrated underreduced pressure. Purification via normal phase column chromatography (Si02, 0-60% ethyl acetate/hexanes) followed by reverse phase column chromatography (C 18, 5-70% acetonitrile/water containing 0.1% formic acid) afforded (+/-)38 (68 mg, 12%) as a white foam. 1H NMR (DMSO-d6, 400 MHz) oe 8.84 (s, 1H), 8.79 (s, 1H),8.40 (s, 1H), 7.74 (d, J= 3.8 Hz, 1H), 7.12 (d, J- 3.8 Hz, lH), 6.24 (s, 2H), 4.54 (td, J= 9.7, 4.3 Hz, 1H), 3.30-3.15 (m, 2H), 2.39 (d, J 9.8 Hz, 1H), 1.68- 1.36 (m, 4H), 1.08 (s, 9H); MS (ESI) 425.3 [(M + H)j.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1146629-77-7, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1146629-77-7, Recommanded Product: 1146629-77-7

To a solution of 37 (514 mg, 1.72 mmol, prepared as described in Lin, Q. et al., Org. Lett., 2009, 11, 1999-2002) in acetonitrile (15 mL) was added 44 (537 mg, 4.29 mmol).Then DBU (540 muL, 3.61 mmol) was added.The reaction was stirred at room temperature for 15 hours.It was then concentrated under reduced pressure in vacuo.The crude mixture was diluted with water and extracted with EtOAc EtOAc.Organic layer merger,Wash with 1N hydrochloric acid,Dry (Na2SO4), filtered and concentrated.Purification by normal phase column chromatography (SiO2, 0-60% ethyl acetate / hexane)(+/-) 45 (368 mg, 50%) to white foam.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, A new synthetic method of this compound is introduced below., Application In Synthesis of (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

The production of tert-butyl-3-(cyanomethyl)-3-[4-(7-{[(2,2- dimethylpropanoyl)oxy] methyl}-7H-pyrrolo[2,3 -d]pirimidin-4-yl)- lH-pyrazol-1-yl] azetidine-1-carboxylate of formula (I) 6.49 ml (6.6 g; 43.43 mmol; 0.5 equ.) of l l,8-diazabicyclo[5.4.0]-undec-7-ene (DBU) is added drop by drop at room temperature to a suspension of 26.00 g (86.87 mmol) of 4-(lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pirimidin-7-yl]methyl 2,2-dimethylpropanoate of formula (X) and 16.87 g (86.87 mmol) of ieri-butyl 3-(cyanomethylidene)azetidine-l-carboxylate of formula (IV) made with 520 ml of acetonitrile. The reaction mixture is stirred for 2 hours at room temperature, then for a further 2 hours at 0-5 C. The precipitated solid material is filtered, then washed on the filter with 2×25 ml of 5 C acetonitrile, then dried at room temperature and atmospheric pressure until constant weight is achieved. In this way 38.8 g (90.0%) of a white solid product is obtained, the purity of which measured with LC MS at 254 nm is 99.8%.Mp. 181.0-183.5 C. IR (KBr): 1739, 1693, 1585, 1380,1124. HNMR (DMSO-ifc, 500 MHz): 8.94 (s, 1H), 8.82 (s, 1H), 8.48 (s, 1H), 7.76 (d, J=3.7 Hz, 1H), 7.22 (d, J=3.8 Hz, 1H), 6.26 (s, 2H), 4.53 (d, J=8.9 Hz, 2H), 4.24 (d, J=9.4 Hz, 2H), 3.68 (s, 2H), 1.42 (s, 9H), 1.10 (s, 9H). CNMR (DMSO-ifc, 125 MHz): 177.16, 155.52, 151.70, 151.69, 150.34, 140.01, 130.14, 130.06, 121.66, 116.94, 113.61, 101.41, 79.60, 66.68, 58.62, 57.05, 26.98, 26.70. Element analysis calculating for the formula theta5Eta3iotaNu704 (M: 493.57); C 60.84%; H 6.33%; N 19.86%.Measured: C 60.39%; H 6.25%; N 19.88%

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.