Reference of 105486-72-4, These common heterocyclic compound, 105486-72-4, name is Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of ethyl 5-bromo-l-methylpyrazole-4-carboxylate (1.0 g, 4.29 mmol), 3- nitrophenylboronic acid (859 mg, 5.15 mmol), sodium carbonate (909 mg, 8.58 mmol dissolved in 4.3 mL water), and bis(triphenylphosphine)palladium(II) dichloride (151 mg, 0.21 mmol) in DME (43 mL) was heated to 90 C overnight. After this time, General Work-up Procedure 1 was followed, and the crude residue was purified by Chromatography A to afford the title compound (710 mg, 60 % yield).
The synthetic route of 105486-72-4 has been constantly updated, and we look forward to future research findings.