Tag: M.W:200-300

Electric Literature of 104599-37-3, The chemical industry reduces the impact on the environment during synthesis 104599-37-3, name is 3,4-Dibromo-5-nitro-1H-pyrazole, I believe this compound will play a more active role in future production and life.

This intermediate, 3,4-dibromo-5-nitro-1H-pyrazole (69 g) was reduced by refluxing with Stannous chloride, dihydrate (135 g) in Ethyl acetate (600 mL) and Ethanol (300 mL) at 110 C. for 45 minutes. The yellow homogenous reaction solution was cooled to room temperature and slowly poured over a vigorously stirring solution of sodium bicarbonate (33 g) in water (200 mL) and ethyl acetate (800 mL). To the resultant slurry was added Celite (30 g), and this slurry was filtered through a bed of Celite. The filter cake was washed with additional ethyl acetate (600 mL). The organic solution was then washed with brine (200 mL), dried over sodium sulfate, filtered, and concentrated in vacuo to give the crude product as an orange oil. The crude product was then purified by flash column chromatography (Biotage, Quad 25; Eluent: 6% EtOH in methylene chloride). This afforded the title compound as a light beige solid (13.2 g, 32%). 1HNMR (400 MHz, DMSO-d6) delta: 5.20, (m, 3H), 11.60, (br s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Dibromo-5-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1226781-82-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1226781-82-3, name is tert-Butyl 2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of 2E (2.1 g, 7.3 mmol)Was dissolved in dichloromethane (25 mL)Cooled to 0 C, trifluoroacetic acid (5 mL) was added,Reaction for 2 hours.The reaction solution was concentrated, quenched by addition of aqueous ammonia (2 mL), and purified by silica gel column chromatography (dichloromethane / methanol (v / v) = 50: 1) to give intermediate 2 as a white solid.

The synthetic route of tert-Butyl 2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

In a three-necked round bottom flask, 186 g of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (VII) was added.(0.91 mol), 900 ml of ethanol, and a solution of sodium hydroxide 44 g, (1.1 mol) dissolved in 900 ml of water, heated to 50C to 80C, and incubated for 3 hours, the reaction of the starting material was complete by TLC, and the ethanol was concentrated under reduced pressure to remove ethanol Add 100ml of toluene to extract, recover toluene in organic phase, cool the water phase to room temperature, adjust the PH value to 1-2 with 31% hydrochloric acid, cool to about 10C for 0.5 hours, filter and dry to obtain product 3- (Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 6 (DFPA) 152 g, yield 95%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 500011-84-7, These common heterocyclic compound, 500011-84-7, name is 3-Bromo-1-(dimethylsulfamoyl)pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3: Preparation of 3-bromo-lff-pyrazole; To 3-bromo-pyrazole-l-sulfonic acid dimethylamide (21.3 g) was slowly added trifluoroacetic acid (30 mL) and stirred at room temperature for 2 h. Hexane was added and the formed precipitate was filtered off and washed with hexane. The filtrate was diluted with MTB-ether, washed with sat. NaHC03-solution, water and brine, dried over MgSO4 and concentrated in vacuum to afford 10.7 g of a colorless oil containing 80% of the title compound of the formulaBrH The residue was used for the next step without further purification .1H-NMR (CDCl3, TMS) 8 (ppm) : 6.37 (IH, d, J = 3 Hz), 7.55 (IH, d, J = 3 Hz), 12.6 (IH, br s).

The synthetic route of 500011-84-7 has been constantly updated, and we look forward to future research findings.

Related Products of 39806-90-1,Some common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound was prepared according to the reported procedures in 90% yield.5 6 To a solution of 4-iodo-1-methyl-1 H-pyrazole (10.0 g, 48.1 mmol) in DCM (192 ml) was added triflic acid (17.08 ml, 192 mmol) and the resulting mixture was stirred at room temperature for 5 min. mCPBA (12.44 g, 72.1 mmol) followed by mesitylene (6.36 g, 52.9 mmol) was then added (in this order). The reaction vessel was sealed and submitted to a 60C oil bath with stirring for 30 min. The reaction mixture was then allowed to reach rt after which it was concentrated in vacuo followed by precipitation by addition of Et20 (100 mL). The mixture was stirred at 0 C for additional 30 min. The solid was collected by filtration and washed with Et20. LCMS m/z 327.3. 1H NMR (400 MHz, DMSO -c/6) d 9.78 (s, 1 H), 8.55 (s, 1 H), 8.06 (s, 1 H), 7.16 (s, 2H), 3.89 (s, 3H), 2.64 (s, 6H), 2.26 (s, 3H). 13C NMR (101 MHz, DMSO-c/e) d 143.02, 142.90, 140.86, 137.02, 129.59, 124.58, 120.80 (q, J = 322.3 Hz), 79.06, 39.43, 26.43, 20.56. 19F NMR (376 MHz, DMSO-c/e) d -77.76.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1-methyl-1H-pyrazole, its application will become more common.

Application of 51516-70-2,Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Intermediate 4 (1mmol) and the intermediate 7 (1mmol) were dissolved in ethanol to the glass flask, then HCl solution was added as a catalyst refluxed at 80C for 15-18h. After the TLC monitoring reaction was completed, the mixture was vacuum filtered and concentrated. Finally, the above crude product can be isolated and purified by column chromatography (Hexane/EtOAc=8:1) to obtain target compounds.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.

Related Products of 1145-01-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 6 The preparation of 1-methyl-3,5-diphenylpyrazole Twenty parts of 3,5-diphenylpyrazole is dissolved in 100 parts xylene containing 7.26 parts of solid anhydrous sodium hydroxide. The reaction mixture is heated to 120C., and 13.8 parts of dimethyl sulfate are added. The reflux temperature drops to 95C., and after 15 minutes at 95C., a reaction mixture sample indicates no unreacted 3,5-diphenylpyrazole is remaining (tlc.) After 30 minutes, the reaction mixture is cooled to 80C. and 50 parts of water are added. Fifty percent aqueous sodium hydroxide is added to bring pH of aqueous phase to between 10 and 11. The organic layer is washed twice with 50 parts of water. For yield determination the xylene is removed in vacuo, producing 19.7 parts of an oil which crystallizes on seeding. Analysis of the product shows it to be 98.5% pure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Diphenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

10199-57-2, name is 5-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 5-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

General procedure: EDCI (1.1 equiv.) and HOBt (1.1 equiv) were added to a solution of the intermediate acid compound 1a-j (1 equiv.) in anhydrous DMF. The reaction mixture was stirred for 1h at ambient temperature, and the L-serine ester (1.1 equiv.) and DIEA (3 equiv.) were added. The solution was heated to 70C for 6h and then cooled to room temperature. The reaction mixture was poured into ice water, and the resulting solid was filtered and dried to give the desired compound.

The synthetic route of 10199-57-2 has been constantly updated, and we look forward to future research findings.

Reference of 345637-71-0, A common heterocyclic compound, 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, molecular formula is C7H7F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: Preparation of 5-methyl-3-(trifluoromethyl)-lH-pyrazole-l -acetyl chloride A mixture of 5-methyl-3-(trifluoromethyl)-lH-pyrazole-l -acetic acid (5.2 g, 25 mmol) in dichloromethane (70 mL) and N,N-dimethylformamide (2 drops) was cooled to 0 C and oxalyl chloride (4.76 g, 37.5 mmol) in dichloromethane (10 mL) was added dropwise. The reaction mixture was stirred at room temperature for 16 h, and then concentrated under reduced pressure to give the title compound as a slightly yellowish solid (5.64 g). H NMR (CDC13): delta 6.38 (s, 1H), 5.27 (s, 2H), 2.31 (s, 3H).

The synthetic route of 345637-71-0 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, molecular formula is C15H17N5O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C15H17N5O2

Step 6. (+/-)-(4-(1 -(2-Cyano- 1 -(2,2,5,5 -d4-cyclopentyl)ethyl)- 1 H-pyrazol-4- yl)-7H-pyrrolol2,3-dlpyrimidin-7-yl)methyl pivalate ((+/-)38). To a solution of 37 (400 mg, 1.34 mmol, preparation described in Lin, Q. et al. Org. Lett., 2009, 1], 1999-2002) in acetonitrile (10 mL) was added 36 (418 mg, 3.34 mmol) followed by DBU (421 tL, 2.81 mmol). The reaction stirred at room temperature for 15 hours then was concentrated under reduced vacuum. The resulting crude mixture was diluted with water and extracted with ethyl acetate (3 x 50 mL). The organic layers were combined, washed with iN HC1, dried (Na2SO4), filtered and concentrated underreduced pressure. Purification via normal phase column chromatography (Si02, 0-60% ethyl acetate/hexanes) followed by reverse phase column chromatography (C 18, 5-70% acetonitrile/water containing 0.1% formic acid) afforded (+/-)38 (68 mg, 12%) as a white foam. 1H NMR (DMSO-d6, 400 MHz) oe 8.84 (s, 1H), 8.79 (s, 1H),8.40 (s, 1H), 7.74 (d, J= 3.8 Hz, 1H), 7.12 (d, J- 3.8 Hz, lH), 6.24 (s, 2H), 4.54 (td, J= 9.7, 4.3 Hz, 1H), 3.30-3.15 (m, 2H), 2.39 (d, J 9.8 Hz, 1H), 1.68- 1.36 (m, 4H), 1.08 (s, 9H); MS (ESI) 425.3 [(M + H)j.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1146629-77-7, its application will become more common.