Category: 1145-01-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3,5-Diphenyl-1H-pyrazole

General procedure: A mixture of chalcone (1d) (208 mg, 1.0 mmol) and TsNHNH2 (205 mg, 1.1 mmol) in EtOH (2 mL) were stirred at room temperature for 48 h and then EtOH (2 mL), NaOH (44.0 mg, 1.1 mmol) were added and the mixture was heated at reflux for 15 h, then the solvent was removed under reduced pressure, then CH3CN (4 mL), NaOH (60 mg, 1.5 mmol) and benzyl bromide (255 mg, 1.5 mmol) were subsequently added and the mixture was stirred at room temperature for 2 h. The product was extracted with Et2O and the organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. Purification by chromatography on silica gel afforded the desired product 4n as white crystalline solid (276 mg, 89% yield). Mp 114-117 C; deltaH (400 MHz, CDCl3) 5.38 (2H, s), 6.66 (1H, s), 7.09 (2H, d, J 7.2 Hz), 7.21-7.30 (4H, m), 7.32-7.42 (7H, m), 7.87 (2H, d, J 7.2 Hz); deltaC (100 MHz, CDCl3) 53.2, 103.7, 125.6, 126.7, 127.4, 127.6, 128.55, 128.56, 128.6, 128.8, 130.6, 133.4, 137.7, 145.4, 150.9; HRMS (ESI): MH+, found 311.1536. C22H19N2 requires 311.1543, numax (liquid film) 3060, 2955, 2924, 2853, 1452, 1361, 1307 cm-1.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1145-01-3.

Reference:
Article; Tang, Meng; Zhang, Fu-Min; Tetrahedron; vol. 69; 5; (2013); p. 1427 – 1433;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 1145-01-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1145-01-3 name is 3,5-Diphenyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of ethyl 3,5-diphenyl-1-hydro-pyrazole (0.20 mmol ), alpha-diazo-1-phenyl-1,3-butanedione ( 0.25 mmol) was added in a 2 5 mL Schrocker tube at room temperature.[Cp * RhCl2] 2 (0·01 mmol), AgSbF6 (0.04 mmol) and tetrahydrofuran (2.00 mL) were added and argon was bubbled through argon for 2 minutes. Stir at 60 C for 24 hours. The reaction was stopped and concentrated under reduced pressure to give a crude product. Finally, rinsed with a mixture of petroleum ether and ethyl acetate, and the column chromatography was rapidly subjected to column chromatography to give the corresponding nitrogen-containing fused heterocyclic compound (83 mg in white, 92% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Diphenyl-1H-pyrazole, and friends who are interested can also refer to it.

Reference:
Patent; Shenyang Normal University; Yang Xiaobo; Wu Songxiao; Jie Jiyang; Li Haoyi; (18 pag.)CN106946877; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1145-01-3

General procedure: A mixture of chalcone (1d) (208 mg, 1.0 mmol) and TsNHNH2 (205 mg, 1.1 mmol) in EtOH (2 mL) were stirred at room temperature for 48 h and then EtOH (2 mL), NaOH (44.0 mg, 1.1 mmol) were added and the mixture was heated at reflux for 15 h, then the solvent was removed under reduced pressure, then CH3CN (4 mL), NaOH (60 mg, 1.5 mmol) and benzyl bromide (255 mg, 1.5 mmol) were subsequently added and the mixture was stirred at room temperature for 2 h. The product was extracted with Et2O and the organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. Purification by chromatography on silica gel afforded the desired product 4n as white crystalline solid (276 mg, 89% yield). Mp 114-117 C; deltaH (400 MHz, CDCl3) 5.38 (2H, s), 6.66 (1H, s), 7.09 (2H, d, J 7.2 Hz), 7.21-7.30 (4H, m), 7.32-7.42 (7H, m), 7.87 (2H, d, J 7.2 Hz); deltaC (100 MHz, CDCl3) 53.2, 103.7, 125.6, 126.7, 127.4, 127.6, 128.55, 128.56, 128.6, 128.8, 130.6, 133.4, 137.7, 145.4, 150.9; HRMS (ESI): MH+, found 311.1536. C22H19N2 requires 311.1543, numax (liquid film) 3060, 2955, 2924, 2853, 1452, 1361, 1307 cm-1.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1145-01-3.

Reference:
Article; Tang, Meng; Zhang, Fu-Min; Tetrahedron; vol. 69; 5; (2013); p. 1427 – 1433;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C15H12N2

To a flame dried flask was added 3,5-diphenylpyrazole (0.21 g, 0.95 mmol), Selectfluor (0.76 g, 2.1 mmol), and dried, ground molecular sieves (3 A) (0.5 g) followed by dry acetonitrile (distilled from CaH2 and stored over molecular sieves) (3 mL) and the mixture was heated at 80 C (oil bath temp) under N2 for 40 min. The dark yellow solution was then diluted with EtOAc and filtered. The filtrate was evaporated onto silica gel and subjected to flash chromatography on silica gel using 10:1 hexanes/EtOAc as eluent to give first difluoropyrazole 2 (0.19 g, 74% yield) and then the hydrated difluoropyrazole 3 (0.054 g, 20% yield) as yellow solids. The products were recrystallized from hexanes (2) or cyclohexane (3) to give analytical samples as pale yellow crystals. Data for 4,4-difluoro-3,5-diphenyl-4H-pyrazole (2): mp 91.2-91.8 C. IR (ATR): 3071, 3054, 1594, 1582, 1556, 1497, 1447, 1379, 1353, 1339, 1220, 1101, 1021, 872, 777, 720, 698, 681 cm-1. 1H NMR (300 MHz, DMSO-d6): 8.05 (d, J = 7.5 Hz, 4H), 7.74-7.64 (m, 6H). 13C NMR (75 MHz, DMSO-d6): 161.8 (t, J = 22.7 Hz), 133.8 (s), 129.9 (s), 127.8 (s), 125.7 (t, J = 265.9 Hz), 124.7 (s). 19F NMR (282 MHz, DMSO-d6): -116.4 (s). Anal. calcd for C15H10F2N2: C, 70.30; H, 3.93; N, 10.93; found: C, 70.41; H, 4.02; N, 10.82. Data for 4,4-difluoro-3,5-diphenyl-4,5-dihydro-1H-pyrazol-5-ol (3): mp 105.6-106.3 C. IR (ATR): 3354, 3238 (broad), 1593, 1571, 1491, 1332, 1449, 1238, 1136, 1068, 1050, 1016, 964, 889, 778, 688, 656, 635 cm-1. 1H NMR (300 MHz, DMSO-d6): 8.77 (s, 1H), 7.69 (d, J = 7.2 Hz, 2H), 7.59-7.56 (m, 2H), 7.48-7.40 (m, 6H), 7.31 (s, 1H). 13C NMR (75 MHz, acetone-d6): 143.9 (dd, J = 22.5 Hz, 24.0 Hz), 136.8 (d, J = 2.3 Hz), 134.2 (s), 130.1 (s), 129.8 (s), 129.6 (s), 128.9 (s), 128.2 (d, J = 1.6 Hz), 126.2 (d, J = 1.6 Hz), 125.3 (dd, J = 251.7 Hz, 261.9 Hz), 92.9 (dd, J = 20.8 Hz, 32.4 Hz). 19F NMR (282 MHz, DMSO-d6): -103.4 (d, J = 259 Hz), -122.7 (d, J = 259 Hz). Anal. calcd for C15H12F2N2O: C, 65.68; H, 4.41; N, 10.21; found: C, 65.58; H, 4.39; N, 10.23.

The synthetic route of 3,5-Diphenyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Related Products of 1145-01-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 3,5-diphenylpyrazole (1) (0.0927 g, 0.42 mmol) and Selectfluor (0.34 g, 0.97 mmol) in non-dried, stock-grade acetonitrile (1.5 mL) was heated at 80 C (oil bath temp) in an open atmosphere for 2 h and 20 min (140 min) and then cooled. Water was added to the dark yellow solution followed by extraction with EtOAc. The organic layers were combined and dried over Na2SO4 and filtered. The filtrate was evaporated onto silica gel and subjected to flash chromatography on silica gel using 10:1 hexanes/EtOAc as eluent to give first difluoropyrazole 2 (0.031 g, 29%) and then hydrated difluoropyrazole 3 (0.077 g, 67%) as yellow solids.

The synthetic route of 3,5-Diphenyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Related Products of 1145-01-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 6 The preparation of 1-methyl-3,5-diphenylpyrazole Twenty parts of 3,5-diphenylpyrazole is dissolved in 100 parts xylene containing 7.26 parts of solid anhydrous sodium hydroxide. The reaction mixture is heated to 120C., and 13.8 parts of dimethyl sulfate are added. The reflux temperature drops to 95C., and after 15 minutes at 95C., a reaction mixture sample indicates no unreacted 3,5-diphenylpyrazole is remaining (tlc.) After 30 minutes, the reaction mixture is cooled to 80C. and 50 parts of water are added. Fifty percent aqueous sodium hydroxide is added to bring pH of aqueous phase to between 10 and 11. The organic layer is washed twice with 50 parts of water. For yield determination the xylene is removed in vacuo, producing 19.7 parts of an oil which crystallizes on seeding. Analysis of the product shows it to be 98.5% pure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Diphenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 1145-01-3,Some common heterocyclic compound, 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, molecular formula is C15H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2d. Under argon atmosphere, CuI (0.38 g, 2 mmol), proline(0.46 g, 4 mmol) and K2CO3(2.76 g, 20 mmol) were added toa dimethyl sulfoxide (15 mL) solution of 6-bromopyridine-2-carboxylate (4.60 g, 20 mmol) and 3,5-diphenylprazole (4.44 g,20 mmol). The formed mixture was stirred at 80C overnight.Water was added after cooling down to room temperature, and theresulting mixture was extracted with ethyl acetate (3¡Á 20 mL). Theorganic layers were combined and the solvent was removed to givethe crude product, which was purified by column chromatography(3.76 g, 83% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Diphenyl-1H-pyrazole, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Product Details of 1145-01-3

A solution of ethyl 3,5-diphenyl-1-hydropyrazole (0.20 mmol ), tert-butyl alpha-diazoacetoacetate ( 0.25 mmol) was added in a 25 mL Schrocker tube at room temperature,[Cp * RhCl2] 2 (0¡¤01 mmol), AgSbF6 (0.04 mmol) and tetrahydrofuran (2.00 mL) were added and argon was bubbled through argon for 2 minutes. Tighten the lid. Stir at 60 C for 24 hours. The reaction was stopped and concentrated under reduced pressure to give a crude product. The column was finally rinsed with a mixture of petroleum ether and ethyl acetate and subjected to rapid column chromatography (silica gel column) to give the corresponding nitrogen-containing fused heterocyclic compound (60 mg of white solid, 84% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

1145-01-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1145-01-3 name is 3,5-Diphenyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3,5-diphenyl-1H-pyrazole (0.36 g, 1.65 mmol) in N,N-dimethylformamide (8.6 mL) was added sodium hydride (60% in oil, 66 mg, 1.65 mmol) under stirring at room temperature, and the mixture was stirred at the same temperature for 30 min. To the reaction mixture was added sodium iodide (22 mg, 0.15 mmol) and a solution of methyl 4-(bromomethyl)-3-isopropoxybenzoate (0.43 g, 1.50 mmol) in N,N-dimethylformamide (4.3 mL), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1-hexane/ethyl acetate=4/1) to give the title compound (0.59 g, yield 92%) as a colorless oil. MS (ESI+): 427 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Diphenyl-1H-pyrazole, and friends who are interested can also refer to it.

1145-01-3, Adding some certain compound to certain chemical reactions, such as: 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1145-01-3.

A solution of ethyl 3,5-diphenyl-1-hydro-pyrazole (0.20 mmol ), alpha-benzyl diazoacetoacetate ( 0.25 mmol) was added in a 2 5 mL Schrocker tube at room temperature.[Cp * RhCl2] 2 (0¡¤01 mmol), AgSbF6 (0.04 mmol) and tetrahydrofuran (2.00 mL) were added and argon was bubbled through argon for 2 minutes. Stir at 25 C for 48 hours. The reaction was stopped and concentrated under reduced pressure to give a crude product. Finally, the mixture was washed with a mixture of petroleum ether and ethyl acetate, and the corresponding nitrogen-containing fused heterocyclic compound (77 mg of white solid, 99% yield) was obtained by flash column chromatography (baby gel column).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1145-01-3.