Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
In a three-necked round bottom flask, 186 g of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (VII) was added.(0.91 mol), 900 ml of ethanol, and a solution of sodium hydroxide 44 g, (1.1 mol) dissolved in 900 ml of water, heated to 50C to 80C, and incubated for 3 hours, the reaction of the starting material was complete by TLC, and the ethanol was concentrated under reduced pressure to remove ethanol Add 100ml of toluene to extract, recover toluene in organic phase, cool the water phase to room temperature, adjust the PH value to 1-2 with 31% hydrochloric acid, cool to about 10C for 0.5 hours, filter and dry to obtain product 3- (Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 6 (DFPA) 152 g, yield 95%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.