Tag: M.W:200-300

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1082745-50-3, name is 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H14N4O2

To a suspension of 0.132 g (0.63 mmol) of 5-amino-1-(tetrahydro-pyran-4-yl)-1-H-pyrazole-4-carboxylic acid amide (see PCT patent application WO2010/026214) in dry EtOH (1.5 mL), 0.066 g (1.66 mmol) of sodium hydride (60% suspension in mineral oil) were added at room temperature under nitrogen. After 10 min, 0.181 mg (0.945 mmol) of Example 13A were added and the reaction mixture was heated to 140 C. for 40 min in a microwave oven (Power 100W). The reaction mixture was then diluted with DCM, water was added, organics separated and dried over sodiumsulphate. Organics were evaporated under reduced pressure and the crude purified by flash chromatography (DCM/IPA 98:2) to obtain the title compound as a white solid. (54 mg, 32%).HPLC-MS (Method 1Eh): Rt=8.01 minMS (APCI pos): m/z=352 (M+H)+ The enantiomers of the title compound were separated by HPLC using a chiral stationary phase.Method for Enantioseparation:Semipreprative Conditions: HPLC semipreparative system: Waters 600 pump; column: Daicel chiralcel OJ-H, 250 mmx20 mm, 5.0 mum; eluent: hexane/EtOH85:15; flow rate: 15 mL/min, Temperature: 25 C.; UV Detection: 254 nm Analytical ConditionsHPLC apparatus type: Agilent 1100; Method 6.1; column: Daicel chiralcel OJ-H, 250 mmx4.6 mm, 5.0 mum; eluent: hexane/EtOH85:15; flow rate: 1 mL/min, Temperature: 25 C.; UVDetection: 254 nm

The synthetic route of 1082745-50-3 has been constantly updated, and we look forward to future research findings.

Related Products of 129768-30-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 129768-30-5, name is Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of ethyl 3-(trifluoromethyl)-li/-pyrazole-5-carboxylate (1.00 g, 4.80 mmol) in l,2-dichloroethane (40 mL) were added cyclopropylboronic acid (0.825 g, 9.61 mmol) and sodium carbonate (1.02 g, 9.61 mmol). The reaction mixture was warmed to 70 C and 2,2′- bipyridine (0.750 g, 4.80 mmol) and copper(II) acetate (0.873 g, 4.80 mmol) were added and the reaction mixture was allowed to stir for 18 h at 70 C. The reaction mixture was cooled to ambient temperature and diluted with a saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate (2 x). The combined organic extracts were washed with a saturated aqueous solution of sodium chloride and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with a gradient of hexanes: ethyl acetate – 95:5 to 50:50 to afford the title compound. MS: m/z = 249.1 [M+H]

The synthetic route of Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Diethyl 3,5-pyrazoledicarboxylate

General procedure: n-Butyltriphenylphosphonium peroxodisulfate (0.5 mmol) was added in small portions to a solution of pyrazole (1 mmol) and iodine (0.6 mmol) in CH3CN/H2O (10 : 2 mL) in a 50 mL round-bottome flask equipped with a magnetic stirrer. The reaction mixture was stirred at ambient temperature for the appropriate time (see table). Upon completion of the reaction, as indicated by TLC, the reaction mixture was poured into an aqueous sodium thiosulfate solution (1 M) and extracted with diethyl ether (3 ¡Á 15 mL). The combined organic layers were dried over MgSO4. The solvent was concentrated in vacuo, the resulting product was purified on silica gel using column chromategraphy (diethyl ether : n-hexane = 1 : 4) to afford the pure compound.

According to the analysis of related databases, 37687-24-4, the application of this compound in the production field has become more and more popular.

Electric Literature of 5932-30-9, A common heterocyclic compound, 5932-30-9, name is Ethyl 5-phenyl-1H-pyrazole-3-carboxylate, molecular formula is C12H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Compound ethyl 1H-indole-2-carboxylate (0.1g, 0.53 mmol) was added to a solution of 6h (0.29 g, 2.6 mmol) in EtOH (10 mL) at ambient temperature. The reaction was refluxed for 6 h and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to yield the target product 1. (yield: 77%). 1H NMR (400 MHz, DMSO-d6) delta 11.74 (s, 1H), 11.44 (s, 1H), 7.66 (t, J = 6.3 Hz, 2H), 7.45 (d, J = 8.3 Hz, 1H), 7.35 – 7.11 (m, 2H), 7.06 (t, J = 7.6 Hz, 1H), 2.28 (s, 1H), 1.87 – 1.60 (m, 3H), 1.38 – 1.21 (m, 7H). 13C NMR (400 MHz, DMSO-d6) delta 157.90, 130.67, 127.46, 124.06, 122.10, 112.79, 103.54, 30.22, 29.13, 28.12. HRMS(ESI) m/z calculated for C16H19N3O [M+Na]+:292.1426, found 292.1420.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 10250-64-3, These common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3: Synthesis of N-{4-[(4-methoxy-6-methylpyrimidin-2- yl)sulfamoyl]phenyl}-l-methyl-3-phenyl-lH-pyrazole-5-carboxamide, 1-90 [00355] Methanesulfonyl chloride (0.04 ml, 0.52 mmol) was added to a stirred mixture of 4- amino-N-(4-methoxy-6-methylpyrimidin-2-yl)benzene-l -sulfonamide (19.2, 110 mg, 0.37 mmol), l-methyl-3 -phenyl- lH-pyrazole-5-carboxylic acid (76mg, 0.37 mmol) and 3-picoline (0.11 ml, 1.12 mmol) in MeCN (dry, 5ml) at 0C. After addition the reaction mixture was allowed to reach rt and stirred for lh. The reaction crude was partitioned between DCM (75ml) and water (50ml). The aqueous layer was further extracted with DCM (2x 50ml) and the combined layers were evaporated to afford a material which was purified by prep HPLC (MeCN /Water, 0.1% formic acid) to obtain 126 mg (68%) of N-{4-[(4-methoxy-6-methylpyrimidin-2- yl)sulfamoyl]phenyl}-l-methyl-3-phenyl-lH-pyrazole-5-carboxamide 1-90 as a colourless solid. 1H NMR (500 MHz, DMSO-d6) delta 12.77 (s, 1H), 10.53 (s, 1H), 7.87 (s, 4H), 7.81 (d, J = 7.2 Hz, 2H), 7.50 (s, 1H), 7.45 (t, J = 7.7 Hz, 2H), 7.35 (t, J = 7.4 Hz, 1H), 6.14 (s, 1H), 4.14 (s, 3H), 3.73 (s, 3H), 2.21 (s, 3H).

Statistics shows that 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 10250-64-3.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, A new synthetic method of this compound is introduced below., name: 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

d) Preparation of 2-(2-chloro-6-fluoro-phenyl)-N-(4-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-2-yl)-acetamide (compound I.as.001) To a solution of 2-(2-chloro-6-fluoro-phenyl)-N-(4-piperidin-4-yl-thiazol-2-yl)-acetamide hydrochloride (0.43 g, 1.1 mmol) in 15 ml of N,N-dimethylformamide are added at 0 C. ethyl(diisopropyl)amine (0.35 g, 2.7 mmol), (5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid (0.25 g, 1.2 mmol) and benzotriazol-1-yloxy-tris(dimethylamino)-phosphonium hexafluorophosphate (0.53 g, 1.2 mmol). The reaction mixture is stirred for 16 h at room temperature and then evaporated. The remainder taken up with ethyl acetate, extracted with 1 N aqueous sodium bicarbonate solution, 0.5 N aqueous hydrochloric acid and brine, dried over sodium sulfate and evaporated. The residue is purified by column chromatography on silica gel (cyclohexane/ethyl acetate 3:1) to give 2-(2-chloro-6-fluoro-phenyl)-N-(4-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]piperidin-4-yl}-thiazol-2-yl)-acetamide (compound I.as.001) as white crystals. m.p. 249-251 C. 1H-NMR (400 MHz, CDCl3): delta=1.62 (dd, 2H), 2.04 (t, 2H), 2.30 (s, 3H), 2.71-2.88 (m, 2H), 3.22 (t, 2H), 3.96-4.03 (m, 3H), 4.60 (d, 1H), 4.99 (q, 2H), 6.32 (s, 1H), 6.53 (s, 1H), 7.11 (t, 1H), 7.28-7.33 (m, 2H), 8.66 (s, 1H). MS: m/z=544 (M+1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 330792-70-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

[0411] A solution of 5-amino-3-(4-phenoxyphenyl)-IH-pyrazole-4-carbonitrile (1.0 g, 3.6mmol) in H3P04 (20 mL) was heated to 120 C for 4 hr. The mixture was then poured into water(100 mL), extracted with EA (100 mL x 3). The combined organic layers were dried overNa2S04 and concentrated to give the product (850 mg, 77.5%) as yellow solid. MS (ESI, m/e)[M+It 295.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 217073-76-2, name is 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C11H9FN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 217073-76-2

General procedure: To a solution of II (1-2 eq.) in dry DMF, dioxane or dichloromethane, particularly dry DMF (dimethylformamide) (3-10 ml) were added IV (1 mmol). HBTU (2-(lH-Benzotriazole-l-yl)- 1,1,3,3-Tetramethyluroniurn hexafluorophosphate) (1 -1.4 eq.), DIPEA (N,N- Diisopropylethylamine) (1-5 eq.) or triethylamine (5 eq.), particularly DIPEA, and optionally DMAP (4-Dimethylaminopyridine ) (0.1 eq.) were also added to the reaction mixture. The reaction temperature was usually in the range of from rt to 85 C, particularly rt. The reaction was usually allowed to process overnight (which as used herein specifies a duration of approximately between 12 and 24 h, depending on the reaction velocity). After completion of the reactions, the reaction solution was subjected to one or more after- treatments including: A) Extraction with organic solvents: The residue obtained from the reaction was dissolved in an organic solvent (such as ethyl acetate or dichloromethane) and was washed at least once with an aqueous 5% NaHC03, aqueous 5% citric acid and water. The organic layer was dried over magnesium sulfate and concentrated in vacuo. B) Chromatography: The crude product obtained from the reaction was purified by column chromatography on a silica gel flash column, by preparative TLC (thin layer chromatography) or preparative HPLC (high pressure liquid chromatography) with a defined eluent proportion. After completion of the reaction, the crude product was purified by siliga gel flash column chromatography (CHCl3/EtOH = 80:1 + 1 drop of HOAc). C) Recrystallization: The crude product was crystallized from ethanol (with activated carbon). D) Precipitation: After completion of the reaction, the reaction mixture was diluted with water, hexane or an aqueous Na2C03-solution and/or was poured into ice water and the formed precipitate was filtered off. E) Washing: The obtained solid (e.g. obtained by filtration) was washed with water, aqueous HC1 or Na2C03-solution and/or organic solvents. F) Suspending, followed by filtration: The crude product was suspended in Et20 (diethyether), filtered off and dried. G) Neutralization and recovery: After completion of the reaction, the solvent was evaporated in vacuo, water was added and the precipitate was formed. An aqueous 3% ammonia solution, or alternatively a sodium hydrogen carbonate solution was added to the suspension till pH = 8. After 30 min of stirring the precipitate was filtered off or the dissolved product was extracted

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 217073-76-2, its application will become more common.

Electric Literature of 741717-63-5, A common heterocyclic compound, 741717-63-5, name is Ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate, molecular formula is C13H11F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of ethyl l-phenyl-3- (trifluoromethyl) -IH- pyrazole-4-carboxylate (6.60 g, 23.2 mmol) and ethylenediamine (50 ml, 23.2 mmol) was heated at reflux for 3 hours. The mixture was concentrated under reduced pressure to a residue. To the residue was added toluene (50 mL) that was concentrate off, twice. The crude solid was dried under high vacuum overnight to give N- (2-aminoethyl) -l-phenyl-3-(trifluoromethyl) -lH-pyrazole-4-carboxamide (6.9 g, 99% yield) as a light tan solid. The desired product may also be isolated as the hydrochloride salt by dissolving in minimal DCM and adding IN HCl in Et2theta (3-5 molar equivalents) dropwise, filtering the solid and washing with Et2theta. 1H NMR (Free base analog) (DMSO-d6) delta 1.83 (br, 2H), 2.68 (t, J = 6.3 Hz, 2H), 3.21-3.26 (m, 2H), 7.47 (t, J = 7.4 Hz, IH), 7.60 (t, J = 8.0 Hzr 2H), 7.84 (d, J = 7.8 Hz, 2H), 8.29-8.30 (m, IH), 9.11 (s, IH); m/z (APCI pos) 299 (60%) (M+H) .

The synthetic route of 741717-63-5 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Iodo-1-methyl-1H-pyrazole

General procedure: 4-Iodo-1-methyl-1H-pyrazole 1 (101 mg, 0.5 mmol) and phenylboronic 2 (59 mg, 0.5 mmol) were dissolved in DME (3 mL) and H2O (1.2 mL) in a microwave vial under a nitrogen atmosphere. Pd(PPh3)4 (2 mmol%, 11.6 mg) and Cs2CO3 (407.3 mg, 1.25 mmol) were added, and the reaction mixture was irradiated in a microwave apparatus at 90 C for 5-12 min. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by silica gel column chromatography using petroleum ether/acetone as eluent to give the title compound.

According to the analysis of related databases, 39806-90-1, the application of this compound in the production field has become more and more popular.