Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, A new synthetic method of this compound is introduced below., name: 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid
d) Preparation of 2-(2-chloro-6-fluoro-phenyl)-N-(4-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-2-yl)-acetamide (compound I.as.001) To a solution of 2-(2-chloro-6-fluoro-phenyl)-N-(4-piperidin-4-yl-thiazol-2-yl)-acetamide hydrochloride (0.43 g, 1.1 mmol) in 15 ml of N,N-dimethylformamide are added at 0 C. ethyl(diisopropyl)amine (0.35 g, 2.7 mmol), (5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid (0.25 g, 1.2 mmol) and benzotriazol-1-yloxy-tris(dimethylamino)-phosphonium hexafluorophosphate (0.53 g, 1.2 mmol). The reaction mixture is stirred for 16 h at room temperature and then evaporated. The remainder taken up with ethyl acetate, extracted with 1 N aqueous sodium bicarbonate solution, 0.5 N aqueous hydrochloric acid and brine, dried over sodium sulfate and evaporated. The residue is purified by column chromatography on silica gel (cyclohexane/ethyl acetate 3:1) to give 2-(2-chloro-6-fluoro-phenyl)-N-(4-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]piperidin-4-yl}-thiazol-2-yl)-acetamide (compound I.as.001) as white crystals. m.p. 249-251 C. 1H-NMR (400 MHz, CDCl3): delta=1.62 (dd, 2H), 2.04 (t, 2H), 2.30 (s, 3H), 2.71-2.88 (m, 2H), 3.22 (t, 2H), 3.96-4.03 (m, 3H), 4.60 (d, 1H), 4.99 (q, 2H), 6.32 (s, 1H), 6.53 (s, 1H), 7.11 (t, 1H), 7.28-7.33 (m, 2H), 8.66 (s, 1H). MS: m/z=544 (M+1).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.