Electric Literature of 10250-64-3, These common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 3: Synthesis of N-{4-[(4-methoxy-6-methylpyrimidin-2- yl)sulfamoyl]phenyl}-l-methyl-3-phenyl-lH-pyrazole-5-carboxamide, 1-90 [00355] Methanesulfonyl chloride (0.04 ml, 0.52 mmol) was added to a stirred mixture of 4- amino-N-(4-methoxy-6-methylpyrimidin-2-yl)benzene-l -sulfonamide (19.2, 110 mg, 0.37 mmol), l-methyl-3 -phenyl- lH-pyrazole-5-carboxylic acid (76mg, 0.37 mmol) and 3-picoline (0.11 ml, 1.12 mmol) in MeCN (dry, 5ml) at 0C. After addition the reaction mixture was allowed to reach rt and stirred for lh. The reaction crude was partitioned between DCM (75ml) and water (50ml). The aqueous layer was further extracted with DCM (2x 50ml) and the combined layers were evaporated to afford a material which was purified by prep HPLC (MeCN /Water, 0.1% formic acid) to obtain 126 mg (68%) of N-{4-[(4-methoxy-6-methylpyrimidin-2- yl)sulfamoyl]phenyl}-l-methyl-3-phenyl-lH-pyrazole-5-carboxamide 1-90 as a colourless solid. 1H NMR (500 MHz, DMSO-d6) delta 12.77 (s, 1H), 10.53 (s, 1H), 7.87 (s, 4H), 7.81 (d, J = 7.2 Hz, 2H), 7.50 (s, 1H), 7.45 (t, J = 7.7 Hz, 2H), 7.35 (t, J = 7.4 Hz, 1H), 6.14 (s, 1H), 4.14 (s, 3H), 3.73 (s, 3H), 2.21 (s, 3H).
Statistics shows that 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 10250-64-3.