Tag: M.W:100-200

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Hydroxy-3-phenylpropanenitrile(SMILESS: N#CCC(O)C1=CC=CC=C1,cas:17190-29-3) is researched.Related Products of 814-94-8. The article 《Ionization of an α-hydrogen of acetonitrile by n-butyllithium and alkali amides. Condensations with ketones and aldehydes to form β-hydroxynitriles》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:17190-29-3).

MeCN underwent mainly ionization of an α-H with BuLi in tetrahydrofuran-hexane, rather than an addition reaction involving the CN group. The former course of reaction was evidenced by an addition of the resulting lithioacetonitrile to benzophenone (I), to form 89% 3-hydroxy-3,3-diphenylpropanonitrile. Similarly, an α-H of MeCN was ionized by Na, Li, and K amides in liquid NH3 and the resulting alkali acetonitrile condensed with I to give this β-hydroxynitrile in 93, 85, and 69% yields, resp. The BuLi method was extended to several other ketones and to BzH. These results illustrate convenient methods for the synthesis of such β-hydroxynitriles, which can be dehydrated with acid to form the corresponding unsaturated nitriles. 26 references.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17190-29-3, is researched, Molecular C9H9NO, about A cobalt-phosphine complex as mediator in the formation of carbon-carbon bonds, the main research direction is cobalt phosphine catalyst carbon bond formation; carbonyl addition halocarbon cobalt catalyst.Safety of 3-Hydroxy-3-phenylpropanenitrile.

Co(PMe3)4, either preformed or prepared in situ by reduction of 1:4 CoCl2 and Me3P with Mg metal in THF, is an efficient mediator for the reaction of carbonyl compounds R1R2CO with activated halocarbons XCR3R4COR5 to give alcs. HOCR1R2CR3R4COR5 (R1 = alkyl, alkenyl, aryl; R2, R3, R4 = H, alkyl; R5 = OMe, OEt, OBu-t, NEt2; R4R5 = CH2CH2O; X = Cl, Br). The reaction proceeds with good yields under very mild conditions and can be carried out in a 1-pot procedure with only a catalytic amount of Co(PMe3)4, provided sufficient Mg metal is also present.

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Safety of 3-Hydroxy-3-phenylpropanenitrile. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Efficient nickel catalyst for coupling of acetonitrile with aldehydes.

A nickel complex of a diarylamido-based PNP ligand is an efficient and robust catalyst for coupling of acetonitrile with aldehydes. The most effective catalyst used in this study was [2-[bis(1-methylethyl)phosphino-κP]-N-[2-[bis(1-methylethyl)phosphino-κP]-4-methylphenyl]-4-(methyl)benzenaminato-κN]chloro nickel triflate.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-4,6-dichloro-5-methylpyrimidine(SMILESS: CC1=C(N=C(N)N=C1Cl)Cl,cas:7153-13-1) is researched.Safety of 3-Hydroxy-3-phenylpropanenitrile. The article 《Structure-Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4 Receptor Ligands》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:7153-13-1).

A series of 2-aminopyrimidines, e.g. I (R1 = H, Me, OMe, NH2, Ph; R2 = H, Cl, I, NHMe, NMe2, Ph, 2-MeOC6H4, 1-naphthyl, 4-pyridyl, etc.), was synthesized as ligands of the histamine H4 receptor (H4R). Starting from a pyrimidine hit that was identified in an HTS campaign, SAR studies were carried out to optimize the potency, which led to compound I (R1 = H; R2 = t-Bu). This compound was further studied by systematically modifying the core pyrimidine moiety, the methylpiperazine at position 4, the NH2 at position 2, and positions 5 and 6 of the pyrimidine ring. The pyrimidine 6 position benefited the most from this optimization, especially in analogs in which the 6-tert-Bu was replaced with aromatic and secondary amine moieties. The highlight of the optimization campaign was compound I (R1 = H; R2 = 4-NCC6H4), which was potent in vitro and was active as an anti-inflammatory agent in an animal model and had antinociceptive activity in a pain model, which supports the potential of H4R antagonists in pain.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Cyanomethylation during the electroreduction of aromatic carbonyl compounds in acetonitrile, published in 1982-04-30, which mentions a compound: 17190-29-3, Name is 3-Hydroxy-3-phenylpropanenitrile, Molecular C9H9NO, Safety of 3-Hydroxy-3-phenylpropanenitrile.

Electrochem. reduction of PhCOR (R = H, Me, Ph) in MeCN gave PhC(OH)RCH2CN, PhCR:CHCN, PhCHRCH2CN, and PhCR(CH2CN)2 in addition to the normal reduction products, PhCHROH and [PhC(OH)R]2. The balance between the nitrile products and the normal reduction products depended on the c.d., temperature, and H2O concentration

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Promising antiproliferative platinum(II) complexes based on imidazole moiety: synthesis, evaluation in HCT-116 cancer cell line and interaction with Ctr-1 Met-rich domain, published in 2015-05-15, which mentions a compound: 22600-77-7, Name is (1H-Imidazol-2-yl)methanamine dihydrochloride, Molecular C4H9Cl2N3, Application In Synthesis of (1H-Imidazol-2-yl)methanamine dihydrochloride.

A series of imidazole based platinum(II) complexes (I-IV) were synthesized and evaluated for their cytotoxicity in HCT-116 cancer cell line, known for being partially resistant to cisplatin but sensitive to oxaliplatin. Lipophilicity was modulated by introducing differently long saturated and unsaturated chains at the N1 of the imidazole moiety. Pt-I displayed the higher cytotoxic effect achieving a IC50 = 38.0 ± 14.1 μM, comparable to the oxaliplatin value. The interaction between the imidazole platinum(II) complexes and the octapeptide called Mets7, the methionine-rich motif mimicking the N-terminal domain of the yCtr-1, was evaluated in order to have a major insight of the uptake and the eventual resistance mechanisms for the so-synthesized novel platinum compounds

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17190-29-3, is researched, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NOJournal, Tetrahedron Letters called One step conversion of highly dipolarophilic olefins to α-hydroxy-β-cyanoadducts with metal fulminate, Author is You, Zhengqing; Lee, Henry Joung, the main research direction is dipolarophile olefin cyanohydroxylation metal fulminate; mercuric fulminate olefin cyanohydroxylation.Related Products of 17190-29-3.

Olefins conjugated with carbonyl, carboxylic ester, and Ph groups as well as highly strained non-conjugated olefin norbornylene were converted to their corresponding α-hydroxy-β-cyanoadducts by treatment with mercuric fulminate and lithium bromide. The transformation appears to go through a 1,3-dipolar cycloaddition of metal fulminate to the olefin followed by a spontaneous cleavage of the resulting heterocycle. Thus, the study provides the first one step cis-cyanohydroxylation of olefinic species.

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Name: 3-Hydroxy-3-phenylpropanenitrile. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about PbCl2/Ga bimetal redox system-mediated carbon-carbon bond formation reactions between carbonyl compounds and ethyl trichloroacetate and iodoacetonitrile. Author is Zhang, Xiao-Lin; Han, Ying; Tao, Wen-Tian; Huang, Yao-Zeng.

In the presence of lead dichloride and a metallic gallium bimetal redox system, carbonyl compounds reacted with Et trichloroacetate and iodoacetonitrile to afford Et β-substituted α,α-dichloropropionates and β-hydroxy nitriles, resp., in moderate to excellent yields.

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Formula: C9H9NO. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Reactions of pentafluorophenyltrimethylsilane and cyanomethyltrimethylsilane with carbonyl compounds catalyzed by cyanide anions. Author is Gostevskii, B. A.; Kruglaya, O. A.; Albanov, A. I.; Vyazankin, N. S..

Treatment of pentafluorophenyltrimethylsilane (I) and cyanomethyltrimethylsilane (II) with enolizable ketones in the presence of a catalytic amount of potassium cyanide-18-crown-6 complex gave the corresponding trimethylsilyl enol ethers. The same dehydrogenative silylation of acetylacetone and benzoylacetone with silane I was extended to the preparation of 2,4-bis(trimethylsiloxy)-1,3-pentadiene and 1-phenyl-1,3-bis(trimethylsiloxy)-1,3-butadiene, resp. The dehydrogenative silylation of acetylacetone and benzoylacetone with dimethylbis(pentafluorophenyl)silane under the same conditions affords novel heterocycles 5-methylene-2,6-dioxa-1-silacyclohex-3-enes. In the reaction studied the silylating ability of the silanes increases in the order Me3SiCN ≃ Me2Si(CN)2 < Me3SiCH2CN < Me3SiC6F5 ≃ Me2Si(C6F5)2. Potassium cyanide-18-crown complex catalyzed the addition of silane I or II to a carbonyl group of non-enolizable compounds such as benzaldehyde, crotonaldehyde, and methyl(triethylgermyl)ketene. Compound(17190-29-3)Formula: C9H9NO received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(3-Hydroxy-3-phenylpropanenitrile), if you are interested, you can check out my other related articles.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17190-29-3, is researched, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NOJournal, Tetrahedron Letters called Facile conversion of epoxides to β-hydroxy nitriles under anhydrous conditions with lithium cyanide, Author is Ciaccio, James A.; Stanescu, Catherine; Bontemps, Jongnic, the main research direction is epoxide cyanation regioselective stereoselective lithium cyanide; nitrile hydroxy; hydroxy nitrile.Safety of 3-Hydroxy-3-phenylpropanenitrile.

Functionalized epoxides, e.g. cyclohexene oxide, are easily and efficiently converted to β-hydroxy nitriles, e.g. trans-2-hydroxycyclohexanecarbonitrile, in good yield with high regio- and stereoselectivity upon treatment with lithium cyanide in refluxing anhydrous THF. The conditions described permit a one-pot conversion of epoxide to 1,3-amino alc. via hydride reduction of the nitrile.

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