In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Promising antiproliferative platinum(II) complexes based on imidazole moiety: synthesis, evaluation in HCT-116 cancer cell line and interaction with Ctr-1 Met-rich domain, published in 2015-05-15, which mentions a compound: 22600-77-7, Name is (1H-Imidazol-2-yl)methanamine dihydrochloride, Molecular C4H9Cl2N3, Application In Synthesis of (1H-Imidazol-2-yl)methanamine dihydrochloride.
A series of imidazole based platinum(II) complexes (I-IV) were synthesized and evaluated for their cytotoxicity in HCT-116 cancer cell line, known for being partially resistant to cisplatin but sensitive to oxaliplatin. Lipophilicity was modulated by introducing differently long saturated and unsaturated chains at the N1 of the imidazole moiety. Pt-I displayed the higher cytotoxic effect achieving a IC50 = 38.0 ± 14.1 μM, comparable to the oxaliplatin value. The interaction between the imidazole platinum(II) complexes and the octapeptide called Mets7, the methionine-rich motif mimicking the N-terminal domain of the yCtr-1, was evaluated in order to have a major insight of the uptake and the eventual resistance mechanisms for the so-synthesized novel platinum compounds
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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics