Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17190-29-3, is researched, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NOJournal, Tetrahedron Letters called Facile conversion of epoxides to β-hydroxy nitriles under anhydrous conditions with lithium cyanide, Author is Ciaccio, James A.; Stanescu, Catherine; Bontemps, Jongnic, the main research direction is epoxide cyanation regioselective stereoselective lithium cyanide; nitrile hydroxy; hydroxy nitrile.Safety of 3-Hydroxy-3-phenylpropanenitrile.
Functionalized epoxides, e.g. cyclohexene oxide, are easily and efficiently converted to β-hydroxy nitriles, e.g. trans-2-hydroxycyclohexanecarbonitrile, in good yield with high regio- and stereoselectivity upon treatment with lithium cyanide in refluxing anhydrous THF. The conditions described permit a one-pot conversion of epoxide to 1,3-amino alc. via hydride reduction of the nitrile.
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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics