Tag: M.W:200-300

Electric Literature of 15115-52-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15115-52-3 name is 4-Bromo-1-phenyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of compound 4-bromo-l -phenyl- lH-pyrazo Ie (0.5 g, 2.3 mmol) in DMSO (50 mL) was added KOAc (0.66 g, 6.8 mmol), bis(pinacolato)diboron (0.63 g, 2.5 mmol) and ¥dCb(dpp{) (0.076g, 0.11 mmol) at room temperature. The reaction mixture was stirred overnight at 8O0C. The result mixture was diluted with EA, washed with brine, dried over Na2SO4, concentrated, purified by chromatography (EA:PE=1: 12) to give l-phenyl-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)-lH- pyrazole (0.3 g, 50%) as light yellow solid

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-phenyl-1H-pyrazole, and friends who are interested can also refer to it.

Related Products of 27069-16-5, A common heterocyclic compound, 27069-16-5, name is 5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C11H10N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of oximic acid (4a-k, 3.6 mmol in 50 mL THF) was added HOBt (3.6 mmol) in an ice-cooled bath. Next, a mixture of cystamine dihydrochloride (1.8 mmol) and TEA (1 mL) in DMSO (6 mL) were added, followed by the addition of EDCI (4.0 mmol). After stirring for 24 h at room temperature, the reaction was quenched with water and extracted with EtOAc (60 mL × 3). The combined organic extracts were washed with brine (50 mL), dried over MgSO4 and then evaporated. The resulting residue was then purified by column chromatography on silica gel as indicated.

The synthetic route of 27069-16-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 92525-10-5, The chemical industry reduces the impact on the environment during synthesis 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.

A mixture of 5-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)-1-((2-(trimethylsilyl)- ethoxy)methyl)-1H-1,2,4-triazole-3-thiol (Intermediate B9) (230 mg, 417.01 mumol, 1 eq), 3-iodo-1-methyl-1H-pyrazole (86 mg, 417.01 mumol, 1 eq), CuI (158 mg, 834.02 mumol, 2 eq) and N,N’-dimethylethane-1,2-diamine (735 mg, 8.34 mmol, 20 eq) in dioxane (4 mL) was stirred at 70C under N2atmosphere for 2 hours. The reaction mixture was poured into water (10 mL) and extracted with EtOAc (3 × 10 mL). The organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuum. The residue was purified by prep-TLC (SiO2, petroleum ether: ethyl acetate, 1:1) to give the title compound (170 mg, 82.7% yield, 98% purity on LCMS) as a yellow solid.1H NMR (400 MHz, CDCl3): d 7.34 (d, 1H), 6.94 (s, 1H), 6.47 (d, 1H), 6.18 (s, 1H), 5.31 (s, 2H), 3.90 (s, 3H), 3.61 (t, 2H), 2.87 (t, 4H), 2.69 (t, 4H), 2.09-2.00 (m, 4H), 1.00- 0.88 (m, 2H), 0.02 (s, 9H).LCMS: m/z 483.2 (M+H)+(ES+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83-10-3, Product Details of 83-10-3

Step 1 ) N-(3-fluoro-4-hvdroxyphenyl)- 1 ,5-dimethyl-3 -oxo-2-phenyl-2,3 -dihydro- 1H- pyrazole-4- carboxamide [0193] To a suspension of 4-amino-2-fluorophenol (2.54 g, 20 mmol) and 1,5- dimethyl-3 -oxo-2- phenyl-2,3 -dihydro- lH-pyrazole-4-carboxylic acid (4.74 g, 20.4 mmol) in DCM (60 mL) were added EDCI (4.6 g, 24 mmol) and HOAT (0.54 g, 4 mmol). The reaction was stirred at 45 C for 12 hours, then cool to rt, quenched with H20 (10 mL), and stirred for another 4 hours. The solid was obtained by filtration and washed with DCM (20 mL x 3), then dried at 60 C in vacuo for 12 hours to give the title compound as a pale yellow solid (6.37 g, 93.4%). MS (ESI, pos. ion) m/z: 342.1 [M+H]+; NMR (400 MHz, DMSO-i): delta (ppm) 10.59 (s, 1H), 9.58 (s, 1H), 7.64 (dd, J= 2.4 Hz, 13.5 Hz, 1H), 7.60 (m, 2H), 7.50 (m, 1H), 7.42 (m, 2H), 6.97 (m, 1H), 6.88 (dd, J= 9.6 Hz, 8.8 Hz, 1H), 3.34 (s, 3H), 2.70 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 30169-25-6, name is 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, A new synthetic method of this compound is introduced below., Product Details of 30169-25-6

3,6-Bis-(3,5-dimethyl-pyrazol-1-yl)-1,2,4,5-tetrazine (1)(4:05 g 15:0 mmol) and 1H-imidazole (2:35 g 35:0 mmol)were suspended in 25 mL acetonitrile and the mixture refluxed for 3 h. After cooling the resulting precipitate was filtered and washed with large amounts of water(1 L), followed by acetonitrile and dichloromethane. 2:69 g (12:6 mmol 84%) of 5 was isolated as an orange powder. – Elemental analysis (C8H6N8, 214.19) exp. (calcd.)in %: C 44.90 (44.86),N 52.03 (52.32), H 2.90 (2.82).- DSC (5 C min1) : Tdec:: 200 C (onset). – 1H NMR([D6]DMSO, 25 C, ppm): d =7.35 (m, 1H, C-H), 8.16 (m,1H, C-H), 8.81 (m, 1H, C-H). – 13C NMR ([D6]DMSO,25 C, ppm): d =117.1 (1C), 121.5 (1C), 132.4 (1C), 153.1(1C). – Raman: n (cm-1)=3158 (10), 3126 (5), 3113 (10),1912 (5), 1537 (7), 1500 (8), 1490 (100), 1407 (13), 1372(2), 1318 (13), 1282 (7), 1254 (2), 1129 (5), 1091 (16), 1048(4), 962 (54), 895 (5), 858 (3), 801 (33), 747 (2), 665 (3), 613 (2). – IR (25 C, ATR): n (cm1)=3155 (w), 3122 (w), 3110(w), 1775 (vw), 1702 (vw), 1648 (vw), 1614 (vw), 1531 (w),1522 (w), 1475 (s), 1366 (w), 1321 (s), 1301 (m), 1260 (m),1233 (w), 1214 (m), 1153 (w), 1104 (m), 1068 (m), 1038(vs), 971 (s), 946 (s), 926 (m), 898 (s), 854 (vs), 762 (vs),693 (w).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 285984-25-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation 17 l-(5-te^-Butyl-2-p-tolyl-2ff-pyrazol-3-ylVcarbamic acid 2.2.2-trichloro-ethyl ester To a solution of 5-te^-butyl-2-^-tolyl-2F-pyrazol-3-ylamine (Regan et al. J. Med. Chem. 2002, 45,2994-3008, 400 g, 1.74 mol) in THF (8L) add a saturated solution of sodium carbonate (2.4 L) and cool the mixture to 0 0C. Then add 2, 2, 2-trichloroethyl chloroformate (406.77 g, 1.92 mol) dropwise and stir mixture at 0 0C for 2 hours. Extract the reaction mixture with ethyl acetate (3 x 6.5L), dry over anhydrous magnesium sulfate and evaporate the solvent. Dissolve the solid in a minimum amount of ethyl acetate and add an excess of hexanes to precipitate the solid. Collect the solid by filtration and dry to obtain the title compound as an off white solid (586 g, 83% yield). (ES+): m/z 406.1 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104599-36-2, name is 3,5-Dibromo-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C3HBr2N3O2

0.369 mol of sodium acetate was introduced into a solution of 0.184 mol of dibromonitropyrazole in 250 ml of N-methylpyrrolidone in a 500 ml three-necked flask, and the reaction medium was brought to 80 C. 0.369 mol of 3-bromopropanol was added dropwise at this temperature. This temperature was maintained for 5 hours. After cooling to room temperature, the medium was poured onto ice with stirring. The 3-(3,5-dibromo-4-nitro-1H-pyrazol-1-yl)propan-1-ol (compound 1) precipitated. It was filtered off by suction, dried, and obtained in a yield of 75%. The mass of the expected compound C6H7Br2N3O3 was detected by mass spectrometry. The NMR analyses (1H 400 MHz and 13C 100.61 MHz DMSO d6) were in accordance with the expected structure.

According to the analysis of related databases, 104599-36-2, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C10H15N3O2

6C (0.418 g, 2.0 mmol) was dissolved in N, N-dimethylformamide (5 mL) at room temperature, cooled to -15 C,Sodium bis (trimethylsilyl) amide (1.5 mL, 2.0 mmol) was added and stirred for 30 min.The oxetane-3-sulfonyl chloride 16d (0.43 g, 2.6 mmol) was added dropwise to the reaction mixture, and the mixture was stirred at room temperature for 16 hours.The reaction system was cooled to 0 C, water (10 mL) was added, filtered, and the filter cake was washed with water (5 mL x 2)Petroleum ether (5 mL x 2). The filter cake was purified by column chromatography (ethyl acetate / petroleum ether (v / v) = 1: 8-1: 4)A white solid 16e (0.30 g, yield 45.6%) was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

These common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-Iodo-1-methyl-1H-pyrazole

Step 2: l -methyl-l H-pyrazole-4-carbonitrile To a solution of 4-iodo- l -methyl- 1 H-pyrazole (55 gm, 0.264 moles) in N,N- dimethylacetamide ( 100 ml) was added potassium ferrocyanide (24.5 gm, 0.058 moles), palladium (II) acetate (0.592 gm, 0.0026 moles) and sodium carbonate (27.98 gm, 0.264 ,moles). The reaction mixture was evacuated and backfilled with nitrogen (3 times). The mixture was stirred for 12 hour at 90- 1 10C. Progress of the reaction was monitored by HPLC. The reaction mixture was cooled to 20-30C, to this added DI water (500 ml), ethyl acetate (500 ml) and stirred for 1 hour at 20-30 C. The reaction mixture was filtered through pad of celite. The organic layer was separated and aqueous layer was extracted with ethyl acetate (200 ml), stirred for 15 min and separated the final aqueous layer and organic layer. The organic layer was washed with brine solution (200 ml). Ethyl acetate was recovered at reduced pressure at 60-70C. The mixture was degassed for 2 hour at reduced pressure at 60- 70C, cooled the mixture to 20-30C. Hexane (400 ml) was added to the mixture and stirred for 1 hour at 20-30C. The solid product obtained was filtered off, washed with cold DI water (100 ml) and dried at 40-50 C to yield the product, 1 -methyl- l H-pyrazole-4-carbonitrile,. Dry wt : 17.94 gm Yield : 0.32 w/w (63%);

The synthetic route of 4-Iodo-1-methyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 56430-08-1, name is 1,5-Dimethyl-2-(p-tolyl)-1H-pyrazol-3(2H)-one, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56430-08-1, SDS of cas: 56430-08-1

General procedure: The mixture of isatin 1 (58.9 mg, 0.4 mmol), antipyrine 2 (37.6 mg, 0.2 mmol) andimidazole (20 mol %, 0.04 mmol) in 1 mL H2O were stirred at 80 . Once thereaction completed, the solid mixture was filtered, washed by water and dried undervacuum to afford the analytically pure products 3. In some cases, the desired pureproducts were obtained by silica gel chromatography using ethyl acetate as eluent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Dimethyl-2-(p-tolyl)-1H-pyrazol-3(2H)-one, other downstream synthetic routes, hurry up and to see.