Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C10H15N3O2
6C (0.418 g, 2.0 mmol) was dissolved in N, N-dimethylformamide (5 mL) at room temperature, cooled to -15 C,Sodium bis (trimethylsilyl) amide (1.5 mL, 2.0 mmol) was added and stirred for 30 min.The oxetane-3-sulfonyl chloride 16d (0.43 g, 2.6 mmol) was added dropwise to the reaction mixture, and the mixture was stirred at room temperature for 16 hours.The reaction system was cooled to 0 C, water (10 mL) was added, filtered, and the filter cake was washed with water (5 mL x 2)Petroleum ether (5 mL x 2). The filter cake was purified by column chromatography (ethyl acetate / petroleum ether (v / v) = 1: 8-1: 4)A white solid 16e (0.30 g, yield 45.6%) was obtained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.