Tag: M.W:200-300

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1245772-13-7, name is Methyl 1-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of Methyl 1-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxylate

Example 256: 2-N-Methyl-2-N-phenyl-6-{5-[1-(2,2,2-trifluoroethyl)-1 H-pyrazol-3-yl]-1 ,2,4- oxadiazol-3-yl}-1 ,3,5-triazine-2,4-diamine (Method 12)Methyl 1-(2,2,2-trifluoroethyl)-1 H-pyrazole-3-carboxylate (Intermediate 204, 0.312 g, 1.5 mmol) was dissolved in a mixture of THF (2 mL), MeOH (2 mL) and water (1 mL); lithium hydroxide (0.188 g, 4.5 mmol) was added and the mixture was stirred at roomtemperature for 16 h. The mixture was concentrated, the residue dissolved in water (1 mL) and the mixture was neutralised. This was extracted with EtOAc (2 x 10 mL), the organic extracts were dried over sodium sulfate and concentrated under vacuum. The crude material was washed with pentane (2 x 10 mL) to afford 1-(2,2,2-trifluoroethyl)-1 H- pyrazole-3-carboxylic acid (0.200 g, 69%). 2-N-methyl-2-N-phenyl-6-{5-[1-(2,2,2- trifluoroethyl)-1 H-pyrazol-3-yl]-1 ,2,4-oxadiazol-3-yl}-1 ,3,5-triazine-2,4-diamine was then prepared from 1-(2,2,2-trifluoroethyl)-1 H-pyrazole-3-carboxylic acid (0.159 g, 0.820 mmol) and 4-amino-N-hydroxy-6-[methyl(phenyl)amino]-1 ,3,5-triazine-2- carboximidamide (prepared in an analogous manner to Intermediate 1 , 0.125 g, 0.483 mmol) according to the method described for Example 251 to afford the title compound (0.110 g, 55%).

The synthetic route of 1245772-13-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; BARKER, Oliver; BENTLEY, Jonathan; BOCK, Mark G.; CAIN, Thomas; CHOVATIA, Praful; DOD, Jennifer Ruth; EUSTACHE, Florence; GLEAVE, Laura; HARGRAVE, Jonathan; HEIFETZ, Alexander; LAW, Richard; RAOOF, Ali; WILLOWS, David; WO2012/35023; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., SDS of cas: 285984-25-0

A heterogeneous mixture of a solution of Na2C03 (3.84 g, 36 mmol) in water (42 mL) and Intermediate A (10.5 g, 45.7 mmol) in isopropyl acetate (130 mL, 1 .082 mol) was stirred vigorously at RT for 5 min and was then treated with phenyl carbonochloridate (5.77 mL, 45.7 mmol). Stirring of the mixture was continued for a further 4 hr after which the layers were separated. The organic phase was added to a solution of Intermediate C (10.0 g, 30.5 mmol) and triethylamine (423 mu?, 3.05 mmol) in isopropyl acetate (60 mL, 51 1 mmol). The reaction mixture was warmed to 48 C for 1 hr, then diluted with isopropyl acetate (190 mL) and cooled to RT for a further 18 hr, during which time a precipitate formed. The precipitate was isolated by filtration, washed with isopropyl acetate and then dried in vacuo at 40 C to afford the title compound, Compound (1 ) as a white solid (anhydrous free base, polymorphic form A) (16.5 g, 92 %); R’ 2.74 min (Method 2); m/z 584 (M+H)+ (ES+); 1H NMR (400 MHz, DMSO-de) delta: 1.30 (9H, s), 2.41 (3H, s), 6.43 (1 H, s), 6.58 (1 H, d), 6.78 (1 H, t), 6.97 (2H, t), 7.28 (2H, br m), 7.39 (2H, d), 7.40 (1 H, d), 7.49 (2H, d), 7.56 (1 H, m), 7.63 (1 H, m), 7.82 (1 H, dd), 7.95 (1 H, d), 8.10 (1 H, d), 8.40 (1 H, d), 8.77 (1 H, s), 9.16 (1 H, br s), 9.50 (1 H, br s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; RESPIVERT LIMITED; ITO, Kazuhiro; CHARRON, Catherine Elisabeth; KING-UNDERWOOD, John; ONIONS, Stuart Thomas; LONGSHAW, Alistair Ian; BROECKX, Rudy; FILLIERS, Walter; COPMANS, Alex; WO2013/50757; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2033-45-6, Product Details of 2033-45-6

In a 50 ml reaction vessel under argon, a solution of crude 4-iodo-3,5-dimethyl-1 H- pyrazole x52 (1.15 g, 5.2 mmol) in 25 ml of dry CH2CI2 is added to 4- methylbenzenesulfonyl chloride (1.18 g, 6.2 mmol). Pyridine (0.42 ml, 5.2 mmol) is added EPO and the mixture is stirred for 16 h at room temperature. The organic phase is washed with water, dried over MgSOphi filtered and concentrated. The residue is purified by column chromatography on silicagel (Ch^C^/hexane: 70/30 (v/v)) to afford 4-iodo-3,5-dimethyl-1- [(4-methylphenyl)sulfonyl]-1H-pyrazole x53 (1.44 g).Yield : 74 %.LC-MS (MH+): 377.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-iodopyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UCB S.A.; WO2006/128692; (2006); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1222174-92-6, name is Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1222174-92-6, COA of Formula: C6H7BrN2O2

Step 2: A solution of the intermediate of step 1 (506 mg, 2.31 mmol) in dioxane (10 mL) was treated withLiOH solution (2 M, 1 mL) and the mixture was stirred at 70 C for 1 h. HCI (1 M) was added and themixture was extracted with EtOAc. The combined organic layers were dried and the volatiles wereremoved under reduced pressure to yield the desired compound (84%).LC-MS (Method 2): mlz [M+Hj = 205.0 (MW calc. = 205.01); R = 0.31 mm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; VOSS, Felix; WACHTEN, Sebastian; KLESS, Achim; RITTER, Stefanie; WO2015/90580; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 51516-67-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51516-67-7, name is 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Intermediate 4 (0.001mol) and 5 (0.001mol) were dissolved in pyridine, phosphorus oxychloride is slowly added dropwise under ice bath conditions, then at 40-60C reacted for 5-8h. Finally, the mixture was poured into 30mL saturated Na2CO3 solution and stirred well. After the mixture was acidified, the saturated CuSO4 solution was used to remove pyridine, which greatly improved the purity and yield of the product. The data for compounds 8I-8VI are provided in the supporting information.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Liu, Hao; Ren, Zi-Li; Wang, Wei; Gong, Jie-Xiu; Chu, Ming-Jie; Ma, Quan-Wei; Wang, Jie-Chun; Lv, Xian-Hai; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 81 – 87;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 398491-59-3, name is tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 398491-59-3

A solution of ethyl chlorocarbonate (8. 9 ml, 93 MMOL) in tetrahydrofuran (THF, 250 ml) was slowly added to a mixture of tert-butyl 3-AMINO-4, 6-dihydropyrrolo [3, 4-CPYRAZOLE-5 (1 H)- CARBOXYLATE (20 G, 89 MMOL) and diisopropylethylamine (DIEA, 92 ml, 528 MMOL) in THF (500 ML) at 0-5 C. The reaction was kept at the same temperature for two hours then allowed to reach room temperature and stirred overnight. The obtained mixture was evaporated to dryness under vacuum, and the resulting residue extracted with ethyl acetate (AcOEt) and water. The organic layer was separated, dried over sodium sulfate and evaporated to dryness. The mixture was purified by flash-chromatography (eluent : ethyl acetate/cyclohexane 4/6 to 7/3) to give 19 G of the title compound as a white solid. [M+H] + 297

The synthetic route of 398491-59-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA ITALIA S.P.A.; WO2005/5427; (2005); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 139308-52-4, These common heterocyclic compound, 139308-52-4, name is Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[1302] to a solution of ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate (500 mg, 2.15 mmol) and NCS (574 mg, 4.30 mmol) was stirred. The mixture was stirred at 160 C for 3h under N2. The reaction mixture was added by addition of cc (20 ml), and then diluted with NaHCO3 (30 ml). The mixture was extracted with DCM (20 ml x 3). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by preparatory- tlc (SiO2, pe:ea = 5: 1). Compound 274a (180 mg, yield: 31.30%) was obtained as a yellow oil. 1H NMR (400mhz, CDCl3) delta 4.34 (q, = 7.1 hz, 2h), 3.85 (s, 3h), 1.46 – 1.24 (m, 3h). MS (ESI) m/z (M+H)+266.9.

The synthetic route of 139308-52-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 1227611-94-0,Some common heterocyclic compound, 1227611-94-0, name is 4-(4-Iodo-1H-pyrazol-1-yl)cyclohexanone, molecular formula is C9H11IN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 25: 2-[4-(4-lodo-pyrazol-1 -yI)-cyclohexylamino]-ethanol 2-Amino-ethanol (0.30 mL; 4.96 mmol; 1.4 eq.) was added in one portion to a solution of4-(4-Iodo-pyrazol-1-yl)-cyclohexanone (intermediate 20; 1.00 g; 3.45 mmol; 1.0 eq.) inEtOH. After 1 h the reaction solution was cooled to 0C and NaBH4 (290 mg; 7.67 mmol;2.2 eq.) added portionwise over 1 mm. After a further 1 h the reaction suspension waspoured into 1 N NaOH solution and extracted with DCM. Combined organic phases werewashed with brine, dried over magnesium sulfate, filtered and concentrated. Purificationusing a SCX-2 cartridge afforded the title compound as a white solid (1.00 g; 84%). 1 HNMR (300 MHz, DMSO) oe 7.94 (s, 1H), 7.49 (s, IH), 4.47 (brs, 1H), 4.12 (m, 1H), 3.45(m, 2H), 2.60 (t, J = 5.8 Hz, 2H), 2.41 (m, 1H), 2.95 (m, 4H), 1.72 (m, 2H), 1.13 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(4-Iodo-1H-pyrazol-1-yl)cyclohexanone, its application will become more common.

Reference:
Patent; ARES TRADING S.A.; CROSIGNANI, Stefano; JORAND-LEBRUN, Catherine; GERBER, Patrick; MUZERELLE, Mathilde; WO2014/8992; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 179692-08-1, These common heterocyclic compound, 179692-08-1, name is Ethyl 4-iodo-1H-pyrazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of Intermediate 74b (2.72 g, 10.2 mmol) in acetonitrile (27 mL) was treated with caesium carbonate (5.0 g, 15.3 mmol) then 2-(2- bromoethoxy)tetrahydro-2H-pyran (1.70 mL, 11.2 mmol) and the mixture was stirred at 60 C for 3.5 h. The mixture was evaporated in vacuo and the residue was partitioned between EtOAc and water. The aqueous layer was then extracted with EtOAc (2 x). The combined organic layers were washed with saturated aqueous sodium bicarbonate solution and brine, dried (Na2S04), filtered and evaporated in vacuo. The residue was purified by FCC, using 0-50% EtOAc in cyclohexane, isolating the lower running spot to give the title compound as a colourless glass (1.57 g, 39%). LCMS (Method 3): Rt 3.67 min, m/z 417 [M+Na+].

The synthetic route of 179692-08-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ALCARAZ, Lilian; HURLEY, Christopher; CRIDLAND, Andrew, Peter; JENNINGS, Andrew, Stephen, Robert; WO2014/195402; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1082745-50-3, name is 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Formula: C9H14N4O2

To a solution of 5-amino-1-tetrahydropyran-4-yl-pyrazole-4-carboxamide (4.78 g, 22.7mmol) in dry THF (200 mL) was added methyl 2-(4-bromophenyl)acetate (7.81 g, 34.1 mmol) and t-BuOK (1 M, 45 mL) in THF (45 mL). The mixture was stirred at 80C for 16 hours. Themixture was quenched with water (30 mL) and adjusted with HCI (iN, aqueous) to pH=7. The mixture was filtered. The filter cake was washed with water (20 mL x 3) to give 6-[(4- bromophenyl)methyl]-1-tetrahydropyran-4-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one (5 g).

According to the analysis of related databases, 1082745-50-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (87 pag.)WO2018/73251; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics