Category: 398491-59-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 398491-59-3, name is tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C10H16N4O2

Ib (500 mg, 2.23 mmol) was dissolved in 10 ml of tetrahydrofuran,683 mul of triethylamine was added followed by 200 mul of methanesulfonyl chloride,After reaction at room temperature for 2 h, the solvent was removed under reduced pressure,Column chromatography (P: E = 1: 1) gave white solid 1c (487 mg, 72%).

The synthetic route of 398491-59-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Ruichuang Zhiyuan Biological Technology Co., Ltd.; Qiao Dehua; (27 pag.)CN106279177; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 398491-59-3, name is tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 398491-59-3

A solution of ethyl chlorocarbonate (8. 9 ml, 93 MMOL) in tetrahydrofuran (THF, 250 ml) was slowly added to a mixture of tert-butyl 3-AMINO-4, 6-dihydropyrrolo [3, 4-CPYRAZOLE-5 (1 H)- CARBOXYLATE (20 G, 89 MMOL) and diisopropylethylamine (DIEA, 92 ml, 528 MMOL) in THF (500 ML) at 0-5 C. The reaction was kept at the same temperature for two hours then allowed to reach room temperature and stirred overnight. The obtained mixture was evaporated to dryness under vacuum, and the resulting residue extracted with ethyl acetate (AcOEt) and water. The organic layer was separated, dried over sodium sulfate and evaporated to dryness. The mixture was purified by flash-chromatography (eluent : ethyl acetate/cyclohexane 4/6 to 7/3) to give 19 G of the title compound as a white solid. [M+H] + 297

The synthetic route of 398491-59-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA ITALIA S.P.A.; WO2005/5427; (2005); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 398491-59-3,Some common heterocyclic compound, 398491-59-3, name is tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate, molecular formula is C10H16N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl chlorocarbonate (8.9 ml, 93 mmol) in THF (250 ml) was added slowly to a mixture of 3-amino-4, 6-dihydro-lH-pyrrolo [3, 4-C] ole-5-carboxylic acid tert-butyl ester (20 g, 89 mmol) and DIISOPROPYLETHYLAMINE (DIEA, 92 ml, 528 mmol) in THF (500 ml) at 0-5C. The reaction was kept at the same temperature for two hours then allowed to reach room temperature and stirred overnight. The obtained mixture was evaporated to dryness under vacuum. The resulting residue was extracted with ethyl acetate and water. The organic phase was separated, dried over sodium sulfate and evaporated to dryness. The mixture was purified by flash-chromatography (eluent : ethyl ACETATE/EYCLOHEXANE 4/6 to 7/3) to give 19 g (72% yield) of the title compound as a white solid. 1H-NMR (400 MHZ, DMSO-S6) ppm: 10. 06 (S, broad signal, 2H), 4. 4-4. 05 (M, 6H), 1.27 (t, 3H) 1 (2, 9H).

The synthetic route of 398491-59-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA ITALIA S.P.A.; WO2004/80457; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 398491-59-3, name is tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate

To the product from Step A (133 mg) in dichloromethane (3 mL) at 0 0C was added N,N- dnsopropylethylamine (0 21 mL) followed by benzyl chloroformate (0 1 mL) The reaction mixture was stirred at 0 0C for 90 mm, then diluted with dichloromethane (10 mL) and poured into saturated aqueous sodium bicarbonate solution The layers were separated and the aqueous phase extracted with dichloromethane (3×10 mL). The combined organic phases were d?ed over anhydrous sodium sulfate, filtered and evaporated in vacuo The residue was purified on a Biotage Horizon system (silica gel, 0 to 80% ethyl acetate/hexanes gradient) to give the title compound LC/MS 359 3 (M+l)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 398491-59-3.