Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., SDS of cas: 285984-25-0
A heterogeneous mixture of a solution of Na2C03 (3.84 g, 36 mmol) in water (42 mL) and Intermediate A (10.5 g, 45.7 mmol) in isopropyl acetate (130 mL, 1 .082 mol) was stirred vigorously at RT for 5 min and was then treated with phenyl carbonochloridate (5.77 mL, 45.7 mmol). Stirring of the mixture was continued for a further 4 hr after which the layers were separated. The organic phase was added to a solution of Intermediate C (10.0 g, 30.5 mmol) and triethylamine (423 mu?, 3.05 mmol) in isopropyl acetate (60 mL, 51 1 mmol). The reaction mixture was warmed to 48 C for 1 hr, then diluted with isopropyl acetate (190 mL) and cooled to RT for a further 18 hr, during which time a precipitate formed. The precipitate was isolated by filtration, washed with isopropyl acetate and then dried in vacuo at 40 C to afford the title compound, Compound (1 ) as a white solid (anhydrous free base, polymorphic form A) (16.5 g, 92 %); R’ 2.74 min (Method 2); m/z 584 (M+H)+ (ES+); 1H NMR (400 MHz, DMSO-de) delta: 1.30 (9H, s), 2.41 (3H, s), 6.43 (1 H, s), 6.58 (1 H, d), 6.78 (1 H, t), 6.97 (2H, t), 7.28 (2H, br m), 7.39 (2H, d), 7.40 (1 H, d), 7.49 (2H, d), 7.56 (1 H, m), 7.63 (1 H, m), 7.82 (1 H, dd), 7.95 (1 H, d), 8.10 (1 H, d), 8.40 (1 H, d), 8.77 (1 H, s), 9.16 (1 H, br s), 9.50 (1 H, br s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; RESPIVERT LIMITED; ITO, Kazuhiro; CHARRON, Catherine Elisabeth; KING-UNDERWOOD, John; ONIONS, Stuart Thomas; LONGSHAW, Alistair Ian; BROECKX, Rudy; FILLIERS, Walter; COPMANS, Alex; WO2013/50757; (2013); A1;,
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