Tag: M.W:100-200

Related Products of 948570-75-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 948570-75-0, name is 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To 17a (1 g, 7.8 mmol) in EtOH (20 mL) was added 10% Pd/C50 mg. The reaction mixture was stirred for 3 h under hydrogen at roomtemperature. The mixture was then filtered with Celite, and the filtratewas concentrated and dried under vacuum to yield 0.74 g (97%) of 18aas a white solid. MS (ESI) m/z 98 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Synthetic Route of 138786-86-4, A common heterocyclic compound, 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, molecular formula is C5H5N3O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) Metallic sodium(6.71 g) was added carefully and slowly to thoroughly dried methanol(830 mL) and the solution was ice-cooled after the fragment of metallic sodium was completely dissolved. Compound(1)(43.61 g) was added to the solution, then methyl iodide(43.64 mL) was added and the mixture was stirred at 60-70C for 4 hours. The reaction solution was concentrated under reduced pressure, chloroform was added to the residue and the mixture was washed with a saturated aqueous sodium bicarbonate solution and brine, dried and the solvent was distilled away. The residue was purified with a silica gel column chromatography(hexane/ethyl acetate=4/1 to 1/1) to give Compound(2)(17.0 g) as a yellow oily substance and Compound(3)(26.8 g) as a colorless powder. Compound(2): APCI-MS(m/e):186[M+H]+, 1HNMR(500MHZ/DMSO-d6 )delta(ppm):3.95(s,3H),4.00(s,3H),8.37(s,1H). Compound(3): APCI-MS(m/e):186[M+H]+, 1HNMR(500MHZ/DMSO-d6 )delta(ppm):3.94(s,3H),4.00(s,3H),8.95(s,1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 110860-60-1, name is Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 110860-60-1

50.0 parts of a compound represented by the above formula (1) was added to 220 parts of isopropanol and heated to 45 C. to be completely dissolved. To this solution was added dropwise 27.0 parts of concentrated hydrochloric acid over 20 minutes.After the addition is complete, the reaction solution is cooled to 5 C.The resulting powder was filtered off. Is it enough with isopropanolAfter washing, it was dried at 50 C. for 3 hours to obtain 50.0 parts (yield 81.0%) of the hydrochloride of the compound represented by the formula (1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

A solution of the pyrazole 3,5-dicarboxylicacid (1.60 mmol, 0.25 g) in thionyl chloride (4 mL) was heated underreflux for 2 h. Excess solvent was then distilled off and the crude 23dried under vacuum. A solution of the crude pyrazole diacylchloride 23,triethylamine (4.8 mmol, 0.67 mL) and DMAP (0.32 mmol, 0.039 g) inanhydrous dichloromethane (13 mL) was cooled in an ice bath and theamine 24 (3.28 mmol, 0.782 g) was added slowly as a solution indichloromethane (3 mL). The reaction mixture was allowed to gradually warm up to room temperatureand stirred overnight. The mixture was then washed with 10percent hydrochloric acid and water, and theorganic layer separated. The aqueous layer was further extracted two more times with dichloromethane.Combined organics were dried with anhydrous sodium sulfate, filtered, concentrated and purified by flashcolumn chromatography to furnish the title compound a white solid in 85percent yield.

According to the analysis of related databases, 3112-31-0, the application of this compound in the production field has become more and more popular.

Synthetic Route of 37622-90-5, These common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

INTERMEDIATE 25 Step A: TERT-BUTYL 4- [ (METHYLSULFONYL) oxy] PIPERIDINE-L-CARBOXYLATE (3.62g, 13. OMMOL) was combined with ethyl 4-pyrazolecarboxylate (2. 0G, 14mmol) in 50ML OF DMF. The mixture was cooled to 0C, and sodium hydride (467mg, 19. 5MMOL) was added. The reaction mixture was then heated at 50C for 10h. Afterwards, it was diluted with diethyl ether (LOOML), washed with water (5 x 100mL) and brine (1 x 100ML), dried over magnesium sulfate, filtered, and concentrated in vacuo. Purification by MPLC (silica gel, 5-100% EtOAc/hexanes) afforded the desired product. ESI-MS calculated for CL6H25N304 : 323.39, FOUND 346 (M+NA).

Statistics shows that Ethyl 4-pyrazolecarboxylate is playing an increasingly important role. we look forward to future research findings about 37622-90-5.

Synthetic Route of 852227-86-2, These common heterocyclic compound, 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

D-15 D-16Step 4. A mixture of D-15 (210 mg, 0.78 mmol) and cesium carbonate (765 mg, 2.35 mmol) in DMF (25 mL) was heated to 60C with stirring then a solution of 5-(chloromethyl)-1 ,3-dimethyl-1 H-pyrazole (1 13 mg, 0.78 mmol) in DMF(10 mL) was added drop wise. The reaction mixture was stirred for 1 hour at 60C. The solids were removed by filtration and the solvent was removed under reduced pressure. Crude D-16 was used as such in the next step.LC-MS: Anal. Calcd. For CisHasNeOs: 376.22; found 377 [M+H]+

The synthetic route of 852227-86-2 has been constantly updated, and we look forward to future research findings.

Application of 304903-10-4, These common heterocyclic compound, 304903-10-4, name is 1-Ethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1-ethylpyrazole-4-carbaldehyde [0.322 g (2.6 mmol)], malonic acid [0.530 g (5.2 mmol)], pyridine (5 mL) and piperidine (0.050 mL) was stirred at 80 C. for 1 h followed by stirring for 3 h at 115 C. The reaction was then poured into water (100 mL) and acidified with conc. HCl. The resulting white ppt., product, was filtered and vacuum dried. Yield=436 mg (99%) MS (m/z): 169 [M+H]

Statistics shows that 1-Ethyl-1H-pyrazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 304903-10-4.

Adding a certain compound to certain chemical reactions, such as: 3994-50-1, name is 1-Methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3994-50-1, Recommanded Product: 1-Methyl-4-nitro-1H-pyrazole

A mixture of a portion (0.7 g) of the material so obtained, platinum oxide (0.05 g), ethyl acetate (5 ml) and ethanol (15 ml) was stirred under 3 atmospheres pressure of hydrogen for 2 hours. The catalyst was removed by filtration and the filtrate was evaporated. There was thus obtained the required starting material (0.6 g); 1H NMR: (DMSOd6) 3.64 (s, 3H), 6.86 (s, IH), 6.97 (s, IH).

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Bromo-1-methyl-1H-pyrazole

To a mixture of 8-3 (80 mg, 0.21 mmol, 1.0 eq) and 8-3a (44 mg, 0.27 mmol, 1.3 eq) in dioxane (3 mL) and H20 (0.15 mL) was added Na2CC>3 (44 mg, 0.42 mmol, 2.0 eq) and Pd(dppf)Cl2 (16 mg, 21 umol, 0.1 eq) in one portion under N2. The mixture was stirred at 100 C for 16 h. LCMS showed the starting material was consumed completely and one peak with desired MS was detected. The reaction mixture was concentrated under reduced pressure to remove solvent, and then added CH3CN (5 mL), filtered to give a black-brown liquid. The residue was purified by prep-HPLC. LCMS and XH NMR confirmed that Compound 8 was obtained (2.20 mg, 6.4 umol, 3.0% yield). LCMS (ESI): RT = 0.835 min, mass calcd. For C17H23N3O2S, 333.15 m/z found 333.9[M+H]+ 1H NMR (400MHz, CDC13) delta 8.44 (br d, J= 7.20 Hz, 1H), 8.04 (s, 1H), 7.64 (br d, J= 8.00 Hz, 1H), 7.41 (br s, 1H), 6.76 (br d, J= 8.80 Hz, 1H), 6.68 (s, 1H), 3.96 (s, 3H), 3.54 (br s, 1H), 3.04 (s, 3H), 2.10 – 2.00 (m, 2H), 1.87 – 1.75 (m, 2H), 1.68 – 1.55 (m, 2H), 1.50 – 1.42 (m, 3H).

The synthetic route of 151049-87-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1128-54-7,Some common heterocyclic compound, 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, molecular formula is C10H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A clean and oven dry sealed tube was charged with 1-phenylpyrazole (1equiv.), and styrene (2.5equiv.), to this added (Rh-Complex 0.5mol%) and Cu(OAc)2.H2O (1 equiv), of water (1mL) as a reaction medium. Thereafter, the reaction mixture was heated at 90-100C under sealed conditions for 12h. The gain in product formation was examined by periodic monitoring through TLC. Then the reaction mixture was cool to room temperature, added water (50mL) and EtOAc (75mL) and the organic layer was extracted thrice, and dried over the anhydrous Na2SO4. The crude product was obtained by evaporating the solvent under reduced pressure. Finally, the product was purified through column chromatography (EtOAc/hexane).

The synthetic route of 1128-54-7 has been constantly updated, and we look forward to future research findings.