Synthetic Route of 1128-54-7,Some common heterocyclic compound, 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, molecular formula is C10H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A clean and oven dry sealed tube was charged with 1-phenylpyrazole (1equiv.), and styrene (2.5equiv.), to this added (Rh-Complex 0.5mol%) and Cu(OAc)2.H2O (1 equiv), of water (1mL) as a reaction medium. Thereafter, the reaction mixture was heated at 90-100C under sealed conditions for 12h. The gain in product formation was examined by periodic monitoring through TLC. Then the reaction mixture was cool to room temperature, added water (50mL) and EtOAc (75mL) and the organic layer was extracted thrice, and dried over the anhydrous Na2SO4. The crude product was obtained by evaporating the solvent under reduced pressure. Finally, the product was purified through column chromatography (EtOAc/hexane).
The synthetic route of 1128-54-7 has been constantly updated, and we look forward to future research findings.