Synthetic Route of 37622-90-5, These common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
INTERMEDIATE 25 Step A: TERT-BUTYL 4- [ (METHYLSULFONYL) oxy] PIPERIDINE-L-CARBOXYLATE (3.62g, 13. OMMOL) was combined with ethyl 4-pyrazolecarboxylate (2. 0G, 14mmol) in 50ML OF DMF. The mixture was cooled to 0C, and sodium hydride (467mg, 19. 5MMOL) was added. The reaction mixture was then heated at 50C for 10h. Afterwards, it was diluted with diethyl ether (LOOML), washed with water (5 x 100mL) and brine (1 x 100ML), dried over magnesium sulfate, filtered, and concentrated in vacuo. Purification by MPLC (silica gel, 5-100% EtOAc/hexanes) afforded the desired product. ESI-MS calculated for CL6H25N304 : 323.39, FOUND 346 (M+NA).
Statistics shows that Ethyl 4-pyrazolecarboxylate is playing an increasingly important role. we look forward to future research findings about 37622-90-5.