Application of 304903-10-4, These common heterocyclic compound, 304903-10-4, name is 1-Ethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 1-ethylpyrazole-4-carbaldehyde [0.322 g (2.6 mmol)], malonic acid [0.530 g (5.2 mmol)], pyridine (5 mL) and piperidine (0.050 mL) was stirred at 80 C. for 1 h followed by stirring for 3 h at 115 C. The reaction was then poured into water (100 mL) and acidified with conc. HCl. The resulting white ppt., product, was filtered and vacuum dried. Yield=436 mg (99%) MS (m/z): 169 [M+H]
Statistics shows that 1-Ethyl-1H-pyrazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 304903-10-4.