Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15366-34-4, Recommanded Product: 15366-34-4

Methyl 1 H-pyrazole-3-carboxylate (12.61 mg, 0.1 mmol) was dissolved in a 0. 105M solution of potassium tert-butoxide in ethanol (1 ml, 11.78 mg, 0.105 mmol). After stirring at room temperature for 5 mins, a 0. 1 M solution of 4-bromo-2- (bromomethyl) phenyl phenylmethyl ether in ethanol (1 ml, 35.6 mg, 0.1 mmol) was added and the resulting solution was stirred and heated at 60C under nitrogen for 4hrs. After cooling the mixture was diluted with ethanol (1 ml) and a 0.5M solution of lithium hydroxide in water (1 ml, 11.97mg, 0. 5mmol) was added. The mixture was stirred overnight at 40C. After cooling 2M hydrochloric acid (0. 3moi, 0. 6mmol) was added and the mixture was diluted with water. Dichloromethane was added and the mixture stirred vigorously. The organic layer was separated and the solvent removed in vacuo. The residue was purified by mass directed autopurification to yield the title compound. 1-({5-bromo-2-[(phenylmethyl) oxy] phenyl} methyl)-5-methyl-1 H-pyrazole-3-carboxylic acid: (10. 7mg, 27.6%). ‘H NMR 8 : 5.08 (2H, s), 5.34 (2H, s), 6.72 (1H, d, J = 2.2Hz), 6.92 (1H, d, J = 8.8Hz), 7.23 (1H, d, J = 2Hz), 7.30-7. 39 (6H, m), 7.45 (1H, d, J = 2Hz). t = 3.38, [MH+] 387, 389 [MH-] 385,387.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.

Reference of 578008-32-9, The chemical industry reduces the impact on the environment during synthesis 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, I believe this compound will play a more active role in future production and life.

Example 13Preparation of 3-(4-fluorophenylsulfinyl)-N-( -methyl-lH-pyrazol-3- vDisoq uinolin- 1-amine[00258] A sealed tube was charged with Pd2(dibenzylideneacetone)3 (14 mg,0.016 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (26 mg, 0.047 mmol), tert-butyl 3 -amino-5 -methyl- lH-pyrazole-l-carboxylate from Example 1 Step D (177 mg, 0.89 mmol), Na2C03 (1 10 mg, 1.04 mmol), l-bromo-3-(4- fluorophenylsulfinyl)isoquinoline from Example 10 Step D (260 mg, 0.74 mmol) and degassed toluene (5.2 mL), and then water (0.014 mL) was added with stirring. The sealed tube was heated in an oil bath at 100 C for 2 h, and then in a microwave synthesizer at 100 C for 1.5 h. The mixture was filtered and the filtrate was concentrated. The solid residue was triturated with MeOH and collected by filtration and dried under reduced pressure to afford tert-butyl 3-(3-(4- fluorophenylsulfinyl)isoquinolin- 1 -ylamino)-5 -methyl- 1 H-pyrazole- 1 -carboxylate (166 mg, 40 %) as a white solid. JH NMR (300 MHz, DMSO-t/6) delta 1.52 (s, 9H), 2.25 (s, 3H), 6.46 (s, 1H), 7.40 (t, 2H), 7.83-7.90 (m, 4H), 8.00-8.03 (m, 2H), 8.17 (d, 1H), 10.61 (s, 1H); LC-MS (ESI) m/z 467 (M + H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, other downstream synthetic routes, hurry up and to see.

Electric Literature of 89181-79-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89181-79-3, name is 3-Amino-1-methyl-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 3 -amino- 1 -methyl- lH-pyrazole-4-carboxamide from Example 20 Step C (100 mg, 0.71 mmol) in HOAc (0.6 mL) were added ethyl carbonocyanidate (77.8 mg, 0.79 mmol) and concentrated HC1 (0.06 mL). The mixture was stirred at 100 C for 5h. The mixture was concentrated and the residue was purified by silica gel chromatography eluting with 100/1 to 50/1 DCM:MeOH to afford ethyl 4-hydroxy-2-methyl-2H-pyrazolo[3,4-d]pyrimidine-6-carboxylate (58 mg, 36% yield) as a white solid. lH NMR (400 MHz, DMSO- 6) delta 12.06 (br s, 1H), 8.59 (s, 1H), 4.36 (q, J= 7.2 Hz, 2H), 4.06 (s, 3H), 1.35 (t, J= 7.2 Hz, 3H). LCMS (ESI) m/z 223 (M + H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-1-methyl-1H-pyrazole-4-carboxamide, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40261-59-4, name is 1-Phenyl-1H-pyrazole-3-carbaldehyde, A new synthetic method of this compound is introduced below., Recommanded Product: 40261-59-4

Step 1 : l-(l-Phenyl-lH-pyrazol-3-yl)-propan-l-ol[0142] 1 -Phenyl- lH-pyrazole-3-carbaldehyde (779 mg, 4.53 mmol) was dissolved in anhydrous TEtaF (9 mL) and chilled in an ice bath. EtMgBr (3.0 M in Et20, 4.5 mL) was added dropwise. After 1.5 hours, the reaction mixture was allowed to warm to ambient temperature. TLC (2:1 hexanes:EtOAc indicated complete consumption of aldehyde starting material. The reaction mixture was quenched with water and extracted with EtOAc (2x). The EtOAc layers were washed with brine (Ix), dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography (2:1 hexanes: EtOAc) to provide the title compound (631 mg, 69%) as a yellow oil. 1H NMR (400 MHz, CDCl3) delta 7.85 (d, IH, J= 2.4 Hz), 7.65 (d, 2H, J= 7.6 Hz), 7.42 (t, 2H, J= 7.6 Hz), 7.27 (d, IH, J= 7.2 Hz), 6.38 (d, IH, J = 2.4 Hz), 4.79 (dd, IH, J= 12, 5.6 Hz), 2.38 (d, IH, J= 4.8 Hz), 1.98-1.81 (m, 2H), 1.01 (t, 3H, J= 7.2 Hz). MS (ES) m/z 203.1 (M+H+).

The synthetic route of 40261-59-4 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6645-69-8 as follows. COA of Formula: C5H5N3O4

To a solution of 2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)aniline(8; 0.14 g,0.58 mmol,1 equiv.)and 2-(4-nitro-lH-pyrazol-1-yl)acetic acid(3b- ; 0.10 g,0.58 mmol,1.0 equiv.)in pyridine(5 ml)slowly added P0C13 (0.49 g,3.21 mmol,7.8 equiv.)at 0 C. The reaction was further maintained at the same temperature for 15 minutes. The reaction mixture was then quenched into ice and the product was then extracted with ethyl acetate. The combined organic layer was washed by IN HC1 solution followed by brine solution,dried over sodium sulfate,filtered and concentrated under reduced pressure to get crude product. The crude product thus obtained was purified by column chromatography on silica gel with a mixture of ethyl acetate and n-hexane as an eluent to obtain 0.038 g of the title compound 1A-1-16 as off white solid.NMR(CDCI3): 8.42(d,J = 7.6 Hz,1H),8.32(s,1H),8.31(bs, 1H),8.24(s,1H),6.99(d,J = 11.6 Hz,1H),5.00(s,2H),3.36(q,J = 9.6 Hz,2H),2.43(s,3H).

According to the analysis of related databases, 6645-69-8, the application of this compound in the production field has become more and more popular.

Related Products of 632365-54-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 632365-54-9 as follows.

A suspension of methyl 5-amino-1H-pyrazole-3-carboxylate (1.00 g, 7.086 mmol) and 1-(3,4-dimethoxyphenyl)-4,4,4-trifluorobutane-1,3-dione (2.153 g, 7.794 mmol) in ACETIC ACID (10 ml, 174.682 mmol) was heated to reflux (at 100 C.) for 5 hours. The mixture was cooled at room temperature, water was added and the precipitate collected by filtration, washed with water and dried under vacuum to give J1 as a green solid, 2.33 g (86% yield).

According to the analysis of related databases, 632365-54-9, the application of this compound in the production field has become more and more popular.

Application of 31037-02-2,Some common heterocyclic compound, 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H11N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 69 Preparation of ethyl 4-Hydroxy-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo-[3,4-b]pyridine-5-carboxylate A solution of sodium metal (12.7 g, 0.55 mol) in ethanol is treated at room temperature with ethyl 5-amino-1-methyl-4-pyrazolecarboxylate (25 g, 0.148 mol), stirred for 0.5 h, treated dropwise with a solution of diethyl malonate (80 ML, 0.52 mol in ethanol over a 0.5 h period, heated at reflux temperature for 56 h, cooled to room temperature, diluted with water, washed with ethyl acetate, acidified to PH 2 with HCl and filtered.The filtercake is washed sequentially with water, ethanol, ethyl acetate and toluene and dried in vacuo at 40 C. for 16 h to afford the title product as a white solid, 28.7 g (82% yield), identified by HNMR analysis.

The synthetic route of 31037-02-2 has been constantly updated, and we look forward to future research findings.

Related Products of 578008-32-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Step 2: Synthesis of tert-Butyl 3-((4-(4-methoxy-4-(methoxycarbonyl)cyclohexyl)-6- methylpyrimidin-2-yl)amino)-5-methyl-lH-pyrazole-l -carboxylate. (0298) Methyl 4-(2-chloro-6-methylpyrimidin-4-yl)- 1-methoxycyclohexane- 1-carboxylate (70.5 mg, 0.236 mmol), tert-butyl 3-amino-5-methyl-lH-pyrazole-l-carboxylate (69.8 mg, 0.354 mmol), di-tert-butyl(2′,4′,6′-triisopropyl-[l, -biphenyl]-2-yl)phosphine (20.0 mg, 0.2 equiv.), Pd2(dba)3 (21.6 mg, 0.1 equiv.), and potassium acetate (70 mg, 0.71 mmol) were combined in a vial under nitrogen and 0.98 mL dioxane was added. The reaction mixture was heated to 115 C for 2 h, then cooled to ambient temperature. The reaction mixture was diluted with EtOAc, filtered through celite, concentrated onto silica gel, and the resulting residue was purified by flash-column chromatography on silica gel (gradient elution, 0 to 100% ethyl acetate-hexanes) to give tert-butyl 3-((4-(4-methoxy-4-(methoxycarbonyl)cyclohexyl)-6-methylpyrimidin-2- yl)amino)-5-methyl-lH-pyrazole-l-carboxylate (48 mg, 44%) as a yellow oil. MS (ES+) C23H33N505 requires: 459, found: 460 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate. I believe this compound will play a more active role in future production and life.

Related Products of 75415-03-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75415-03-1 as follows.

General procedure: Compound 4a (2 mmol), NaH (2.4 mmol) and indole were dissolved in DMF (10 mL). The reaction mixture was stirred at room temperature for 12h before diluted with water (20 mL) and extracted with ethyl acetate (30 mL ¡Á 3). The organic layer was concentrated in vacuum. Purication by ash column chromatography gave the target product 5h.

According to the analysis of related databases, 75415-03-1, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35691-93-1, Formula: C8H12N2O2

4.2.1 Ethyl 2,5-dimethylpyrazolo[1,5-a]quinoline-3-carboxylate (5a) Condition A: A mixture of 2-fluoroacetophenone 3a (138 mg, 1.00 mmol), 1H-pyrazole 2a (202 mg, 1.20 mmol) and K2CO3 (420 mg, 3.00 mmol) in DMF (5.0 mL) was stirred at 120 C for 16 h. After monitoring the end of the reaction on TLC, the mixture was cooled to room temperature and diluted with water. The resulting mixture was extracted with ethyl acetate twice. The combined organic layers were washed with water twice, dried over MgSO4 and the solvent was removed in vacuo to afford a residue. The residue was purified by flash column chromatography (hexane:EtOAc=5:1) on silica gel to afford 5a (92.0 mg, 34% yield). Condition B: The reaction was carried out with Cs2CO3 instead of K2CO3 under the same conditions as that of Condition A to afford 5a (210 mg, 78% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.