Category: 89181-79-3

89181-79-3, name is 3-Amino-1-methyl-1H-pyrazole-4-carboxamide, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 3-Amino-1-methyl-1H-pyrazole-4-carboxamide

General procedure: To a solution of carboxamides 11-14 (0.015 mol) in dry acetone(10 mL), benzoyl isothiocyante (0.0165 mol, 1.1 equiv) was addedand refluxed at 60 C for 12 h. The reaction mixture was cooled.The resulting yellow solid was filtered, washed with acetone and dried under vacuum. The crude product was further recrystalizedfrom methanol to obtain a pure solids.

The synthetic route of 89181-79-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Venkatesan, Gopalakrishnan; Paira, Priyankar; Cheong, Siew Lee; Vamsikrishna, Kosaraju; Federico, Stephanie; Klotz, Karl-Norbert; Spalluto, Giampiero; Pastorin, Giorgia; Bioorganic and Medicinal Chemistry; vol. 22; 5; (2014); p. 1751 – 1765;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 89181-79-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89181-79-3, name is 3-Amino-1-methyl-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 3 -amino- 1 -methyl- lH-pyrazole-4-carboxamide from Example 20 Step C (100 mg, 0.71 mmol) in HOAc (0.6 mL) were added ethyl carbonocyanidate (77.8 mg, 0.79 mmol) and concentrated HC1 (0.06 mL). The mixture was stirred at 100 C for 5h. The mixture was concentrated and the residue was purified by silica gel chromatography eluting with 100/1 to 50/1 DCM:MeOH to afford ethyl 4-hydroxy-2-methyl-2H-pyrazolo[3,4-d]pyrimidine-6-carboxylate (58 mg, 36% yield) as a white solid. lH NMR (400 MHz, DMSO- 6) delta 12.06 (br s, 1H), 8.59 (s, 1H), 4.36 (q, J= 7.2 Hz, 2H), 4.06 (s, 3H), 1.35 (t, J= 7.2 Hz, 3H). LCMS (ESI) m/z 223 (M + H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-1-methyl-1H-pyrazole-4-carboxamide, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89181-79-3, name is 3-Amino-1-methyl-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 3-Amino-1-methyl-1H-pyrazole-4-carboxamide

A solution of 2,2-difluoro-2-(4-fluorophenyl) acetic acid(prepared according to Middleton et al, J. Org. Chem., 1980, 45(14); 2883-2887 by reaction of ethyl 2-(4-fluorophenyl)-2-oxoacetate with (diethylamino)sulfur trifluoride followed by ester saponification) (136 mg, 0.71 mmol) and HATU (380 mg, 0.86 mmol) in THF (1.5 mL) was stirred at rt for 10 min. 3-Amino-l-methyl-lH-pyrazole- 4-carboxamide (100 mg, 0.71 mmol) and TEA (87 mg, 0.86 mmol) were added and the mixture was stirred at rt overnight. The mixture was filtered and the filtrate was concentrated. The residue was dissolved in EtOAc and washed with aq NH4CI and brine. The organic layer was separated and concentrated under reduced pressure to afford 3-(2,2-difluoro-2-(4-fluorophenyl)acetamido)-l-methyl-lH-pyrazole-4- carboxamide (170 mg, 76%) as a yellow solid. H NMR (300 MHz, DMSO-t 6) delta 11.29 (s, 1H), 8.15 (s, 1H), 7.71-7.75 (m, 3H), 7.41 (t, 2H), 7.32 (br s, 1H), 3.81 (s, 3H). LCMS (ESI) m/z 311 (M – H)~.

The synthetic route of 89181-79-3 has been constantly updated, and we look forward to future research findings.