Adding a certain compound to certain chemical reactions, such as: 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15366-34-4, Recommanded Product: 15366-34-4
Methyl 1 H-pyrazole-3-carboxylate (12.61 mg, 0.1 mmol) was dissolved in a 0. 105M solution of potassium tert-butoxide in ethanol (1 ml, 11.78 mg, 0.105 mmol). After stirring at room temperature for 5 mins, a 0. 1 M solution of 4-bromo-2- (bromomethyl) phenyl phenylmethyl ether in ethanol (1 ml, 35.6 mg, 0.1 mmol) was added and the resulting solution was stirred and heated at 60C under nitrogen for 4hrs. After cooling the mixture was diluted with ethanol (1 ml) and a 0.5M solution of lithium hydroxide in water (1 ml, 11.97mg, 0. 5mmol) was added. The mixture was stirred overnight at 40C. After cooling 2M hydrochloric acid (0. 3moi, 0. 6mmol) was added and the mixture was diluted with water. Dichloromethane was added and the mixture stirred vigorously. The organic layer was separated and the solvent removed in vacuo. The residue was purified by mass directed autopurification to yield the title compound. 1-({5-bromo-2-[(phenylmethyl) oxy] phenyl} methyl)-5-methyl-1 H-pyrazole-3-carboxylic acid: (10. 7mg, 27.6%). ‘H NMR 8 : 5.08 (2H, s), 5.34 (2H, s), 6.72 (1H, d, J = 2.2Hz), 6.92 (1H, d, J = 8.8Hz), 7.23 (1H, d, J = 2Hz), 7.30-7. 39 (6H, m), 7.45 (1H, d, J = 2Hz). t = 3.38, [MH+] 387, 389 [MH-] 385,387.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.