Electric Literature of 89181-79-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89181-79-3, name is 3-Amino-1-methyl-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 3 -amino- 1 -methyl- lH-pyrazole-4-carboxamide from Example 20 Step C (100 mg, 0.71 mmol) in HOAc (0.6 mL) were added ethyl carbonocyanidate (77.8 mg, 0.79 mmol) and concentrated HC1 (0.06 mL). The mixture was stirred at 100 C for 5h. The mixture was concentrated and the residue was purified by silica gel chromatography eluting with 100/1 to 50/1 DCM:MeOH to afford ethyl 4-hydroxy-2-methyl-2H-pyrazolo[3,4-d]pyrimidine-6-carboxylate (58 mg, 36% yield) as a white solid. lH NMR (400 MHz, DMSO- 6) delta 12.06 (br s, 1H), 8.59 (s, 1H), 4.36 (q, J= 7.2 Hz, 2H), 4.06 (s, 3H), 1.35 (t, J= 7.2 Hz, 3H). LCMS (ESI) m/z 223 (M + H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-1-methyl-1H-pyrazole-4-carboxamide, other downstream synthetic routes, hurry up and to see.