Tag: M.W=100-150

Labadie, Sharada published the artcileDesign and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors, Synthetic Route of 763120-58-7, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(21), 5923-5930, database is CAplus and MEDLINE.

A highly ligand efficient, novel 8-oxo-pyridopyrimidine containing inhibitor of Jak1 and Jak2 isoforms with a pyridone moiety as the hinge-binding motif was discovered. Structure-based design strategies were applied to significantly improve enzyme potency and the polarity of the mol. was adjusted to gain cellular activity. The crystal structures of two representative inhibitors bound to Jak1 were obtained to enable SAR exploration.

Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Synthetic Route of 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Young, Mary Beth published the artcileDiscovery and Evaluation of Potent P₁ Aryl Heterocycle-Based Thrombin Inhibitors, Computed Properties of 724710-02-5, the publication is Journal of Medicinal Chemistry (2004), 47(12), 2995-3008, database is CAplus and MEDLINE.

In an effort to discover potent, clin. useful thrombin inhibitors, a rapid analog synthetic approach was used to explore the P₁ region. Various benzylamines were coupled to a pyridine/pyrazinone P₂-P₃ template. One compound, i.e. 2-[6-chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-N-(2-[1,2,3]thiadiazol-4-yl-benzyl)acetamide, was found to have a thrombin K_i of 0.84 nM. A study of ortho-substituted five-membered-ring heterocycles was undertaken and subsequently demonstrated that the o-triazole and tetrazole rings were optimal. Combination of these potent P₁ aryl heterocycles with a variety of P₂-P₃ groups produced a compound with an extraordinary thrombin inhibitory activity of 1.4 pM. It is hoped that this potency enhancement in P₁ will allow for more diversification in the P₂-P₃ region to ultimately address addnl. pharmacol. concerns.

Journal of Medicinal Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C11H10N4, Computed Properties of 724710-02-5.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Luque, Rafael published the artcileMagnetically separable nanoferrite-anchored glutathione. Aqueous homocoupling of aryl-boronic acids under microwave irradiation, Application of (1H-Pyrazol-5-yl)boronic acid, the publication is Green Chemistry (2010), 12(9), 1540-1543, database is CAplus.

A highly active, stable and magnetically separable glutathione-based organocatalyst provided very good to excellent yields to sym. biaryls in the homocoupling of aryl-boronic acids under microwave irradiation

Green Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Application of (1H-Pyrazol-5-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Favalli, Nicholas published the artcileLarge screening of DNA-compatible reaction conditions for Suzuki and Sonogashira cross-coupling reactions and for reverse amide bond formation, Quality Control of 724710-02-5, the publication is Bioorganic & Medicinal Chemistry (2021), 116206, database is CAplus and MEDLINE.

Progress in DNA-encoded chem. library synthesis and screening crucially relies on the availability of DNA-compatible reactions, which proceed with high yields and excellent purity for a large number of possible building blocks. In the past, exptl. conditions have been presented for the execution of Suzuki and Sonogashira cross-coupling reactions on-DNA. In this article, our aim was to optimize Suzuki and Sonogashira reactions, comparing our results to previously published procedures. We have tested the performance of improved conditions using 606 building blocks (including boronic acids, pinacol boranes and terminal alkynes), achieving >70% conversion for 84% of the tested mols. Moreover, we describe efficient exptl. conditions for the on-DNA synthesis of amide bonds, starting from DNA derivatives carrying a carboxylic acid moiety and 300 primary, secondary and aromatic amines, as amide bonds are frequently found in DNA-encoded chem. libraries thanks to their excellent DNA compatibility.

Bioorganic & Medicinal Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Quality Control of 724710-02-5.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Favalli, Nicholas published the artcileLarge screening of DNA-compatible reaction conditions for Suzuki and Sonogashira cross-coupling reactions and for reverse amide bond formation, HPLC of Formula: 763120-58-7, the publication is Bioorganic & Medicinal Chemistry (2021), 116206, database is CAplus and MEDLINE.

Progress in DNA-encoded chem. library synthesis and screening crucially relies on the availability of DNA-compatible reactions, which proceed with high yields and excellent purity for a large number of possible building blocks. In the past, exptl. conditions have been presented for the execution of Suzuki and Sonogashira cross-coupling reactions on-DNA. In this article, our aim was to optimize Suzuki and Sonogashira reactions, comparing our results to previously published procedures. We have tested the performance of improved conditions using 606 building blocks (including boronic acids, pinacol boranes and terminal alkynes), achieving >70% conversion for 84% of the tested mols. Moreover, we describe efficient exptl. conditions for the on-DNA synthesis of amide bonds, starting from DNA derivatives carrying a carboxylic acid moiety and 300 primary, secondary and aromatic amines, as amide bonds are frequently found in DNA-encoded chem. libraries thanks to their excellent DNA compatibility.

Bioorganic & Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, HPLC of Formula: 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Sabate-Alduy, Catherine published the artcile1,3-Dipolar cycloaddition of diazomethane Orientation of the addition of diazoalkanes to acetylenic compounds α-substituted with an alcohol or an ether group, Product Details of C5H8N2O, the publication is Bulletin de la Societe Chimique de France (1972), 2764-9, database is CAplus.

The reaction of CH2N2 with acetylenic alcs. RR1CR2CCH (R and R1 = H, Me, Ph; (RR1) = (CH2)5; R2 = OH, NH2, OMe) was not stereospecific, giving 40-80% of the pyrazoles I and 20-60% of their isomers II (R3 = H). On the other hand the reaction with MeCHN2 was stereospecific, giving 80-100% I (R3 = Me). CH2N2 reacted with Me 3-(1-hydroxycyclohexyl)-propiolate to give 100% II [(RR1) = (CH2)5, R2 = OH, R3 = CO2Me , whereas with MeCHN2 a mixture of the isomers was obtained. Charge distribution calculations by the CNDO/2 method confirm that the polarity of the acetylenic mol. determines the direction of the addition, rather than steric effects.

Bulletin de la Societe Chimique de France published new progress about 37599-34-1. 37599-34-1 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Ether, name is 4-(methoxymethyl)-1H-pyrazole, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Monastyrskyi, Andrii published the artcileDiscovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors, Formula: C3H5BN2O2, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(3), 400-404, database is CAplus and MEDLINE.

The development of a new series of apoptosis signal-regulating kinase 1 (ASK1) inhibitors is described. Starting from purine, pyrimidine and quinazoline scaffolds identified by high throughput screening, the authors used tools of structure-based drug design to develop a series of potent kinase inhibitors, including 2-arylquinazoline derivatives 12 (N-(3-(quinazolin-2-ylamino)phenyl)acetamide) and 23 (N-(3-(6-((N-pyrazol-4-yl)quinazolin-2-yl)amino)phenyl)acetamide), with submicromolar inhibitory activities against ASK1. Kinetic anal. demonstrated that the 2-arylquinazoline scaffold ASK1 inhibitors described herein are ATP competitive.

Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Formula: C3H5BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Meredith, Erik L. published the artcileIdentification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D, Name: (1H-Pyrazol-5-yl)boronic acid, the publication is Journal of Medicinal Chemistry (2010), 53(15), 5422-5438, database is CAplus and MEDLINE.

The synthesis and biol. evaluation of potent and selective PKD (protein kinase D) inhibitors, e.g. I, are described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC (Histone deacetylase) kinases. The PKD inhibitors of the present study blunt phosphorylation and subsequent nuclear export of HDAC4/5 in response to diverse agonists. These compounds further establish the central role of PKD as an HDAC4/5 kinase and enhance the current understanding of cardiac myocyte signal transduction. The in vivo efficacy of a representative example compound on heart morphol. is reported herein.

Journal of Medicinal Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Name: (1H-Pyrazol-5-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Meredith, Erik L. published the artcileIdentification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D, Safety of 1H-Pyrazole-4-boronic acid, the publication is Journal of Medicinal Chemistry (2010), 53(15), 5422-5438, database is CAplus and MEDLINE.

The synthesis and biol. evaluation of potent and selective PKD (protein kinase D) inhibitors, e.g. I, are described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC (Histone deacetylase) kinases. The PKD inhibitors of the present study blunt phosphorylation and subsequent nuclear export of HDAC4/5 in response to diverse agonists. These compounds further establish the central role of PKD as an HDAC4/5 kinase and enhance the current understanding of cardiac myocyte signal transduction. The in vivo efficacy of a representative example compound on heart morphol. is reported herein.

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Safety of 1H-Pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Oza, Vibha published the artcileSynthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors, Computed Properties of 763120-58-7, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(6), 2330-2337, database is CAplus and MEDLINE.

Checkpoint kinase 1 (Chk1, CHEK1) is a Ser/Thr protein kinase that plays a key role in mediating the cellular response to DNA damage. Synthesis and evaluation of a previously described class of Chk1 inhibitors, triazoloquinolones/triazolones (TZs) is further described. Investigation of structure-activity relationships led to the identification of potent inhibitors I [R¹ = 2-thienyl, 2-pyrrolyl, R² = NH₂; R¹ = 2-pyrrolyl, R² = CH₂OH (II)]. Key challenges included modulation of physicochem. properties and pharmacokinetic parameters to enable compound testing in a Chk1 specific hollow fiber pharmacodynamic model. In this model, II was shown to abrogate topotecan-induced cell cycle arrest in a dose dependent manner. The demonstrated activity of TZs in this model in combination with a chemotherapeutic agent as well as radiotherapy validates this series of Chk1 inhibitors. X-ray crystal structures for an initial lead and an optimized analog are also presented.

Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Computed Properties of 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics