Monastyrskyi, Andrii published the artcileDiscovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors, Formula: C3H5BN2O2, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(3), 400-404, database is CAplus and MEDLINE.
The development of a new series of apoptosis signal-regulating kinase 1 (ASK1) inhibitors is described. Starting from purine, pyrimidine and quinazoline scaffolds identified by high throughput screening, the authors used tools of structure-based drug design to develop a series of potent kinase inhibitors, including 2-arylquinazoline derivatives 12 (N-(3-(quinazolin-2-ylamino)phenyl)acetamide) and 23 (N-(3-(6-((N-pyrazol-4-yl)quinazolin-2-yl)amino)phenyl)acetamide), with submicromolar inhibitory activities against ASK1. Kinetic anal. demonstrated that the 2-arylquinazoline scaffold ASK1 inhibitors described herein are ATP competitive.
Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Formula: C3H5BN2O2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics