Sabate-Alduy, Catherine’s team published research in Bulletin de la Societe Chimique de France in | CAS: 37599-34-1

Bulletin de la Societe Chimique de France published new progress about 37599-34-1. 37599-34-1 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Ether, name is 4-(methoxymethyl)-1H-pyrazole, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.

Sabate-Alduy, Catherine published the artcile1,3-Dipolar cycloaddition of diazomethane Orientation of the addition of diazoalkanes to acetylenic compounds α-substituted with an alcohol or an ether group, Product Details of C5H8N2O, the publication is Bulletin de la Societe Chimique de France (1972), 2764-9, database is CAplus.

The reaction of CH2N2 with acetylenic alcs. RR1CR2CCH (R and R1 = H, Me, Ph; (RR1) = (CH2)5; R2 = OH, NH2, OMe) was not stereospecific, giving 40-80% of the pyrazoles I and 20-60% of their isomers II (R3 = H). On the other hand the reaction with MeCHN2 was stereospecific, giving 80-100% I (R3 = Me). CH2N2 reacted with Me 3-(1-hydroxycyclohexyl)-propiolate to give 100% II [(RR1) = (CH2)5, R2 = OH, R3 = CO2Me , whereas with MeCHN2 a mixture of the isomers was obtained. Charge distribution calculations by the CNDO/2 method confirm that the polarity of the acetylenic mol. determines the direction of the addition, rather than steric effects.

Bulletin de la Societe Chimique de France published new progress about 37599-34-1. 37599-34-1 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Ether, name is 4-(methoxymethyl)-1H-pyrazole, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics