Meredith, Erik L. published the artcileIdentification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D, Safety of 1H-Pyrazole-4-boronic acid, the publication is Journal of Medicinal Chemistry (2010), 53(15), 5422-5438, database is CAplus and MEDLINE.
The synthesis and biol. evaluation of potent and selective PKD (protein kinase D) inhibitors, e.g. I, are described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC (Histone deacetylase) kinases. The PKD inhibitors of the present study blunt phosphorylation and subsequent nuclear export of HDAC4/5 in response to diverse agonists. These compounds further establish the central role of PKD as an HDAC4/5 kinase and enhance the current understanding of cardiac myocyte signal transduction. The in vivo efficacy of a representative example compound on heart morphol. is reported herein.
Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Safety of 1H-Pyrazole-4-boronic acid.
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