Tag: M.W:100-200

Related Products of 92933-47-6, A common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, molecular formula is C7H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of HATU (174.17 mg, 0.459 mmol) and 3-isopropylpyrazole-5-carboxylic acid (59.85 mg, 0.388 mmol) in DMF (2 mL) was then added diisopropylethylamine (92 muL, 0.529 mmol). The reaction solution was stirred at room temperature for 2 h. The N-(3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)benzamide (100 mg, 0.353 mmol) was added in one portion. The solution was then stirred at room temperature overnight. The reaction was diluted with methylene chloride and washed. The aqueous layer was extracted with methylene chloride twice, the combined organic phases were dried over anhydrous MgSO4. After evaporation of the solvent and recrystallization from ethyl acetate, filtered and dried to give desired compound (50 mg, 34%). 1H NMR (300 MHz, DMSO-d6) ppm 13.00 (s, 1H), 11.93 (s, 1H), 7.98 (d, J = 7.40 Hz, 2H), 7.67 (t, J = 7.15 Hz, 1H), 7.59 (t, J = 7.47 Hz, 2H), 6.40 (s, 1H), 5.18 (br. s., 0.9H), 4.75 (br. s., 1.1H), 4.20 (br. s., 1.2H), 3.93 (br. s., 0.8H), 2,91-3.10 (m, 1H), 2.78 (br. s., 2H), 1.25 (d, J = 5.7 Hz, 6H). 13C NMR (101 MHz, DMSO-d6) ppm 166.7, 164.5, 146.7, 147.0, 139.5, 139.2, 133.3, 132.7, 131.0, 128.8, 125.9, 114.3, 104.1, 95.6, 44.0, 41.5, 25.6, 25.4 22.7. LC/MS (ESI+, MeCN/H2O): m/z: calcd for C22H21N5O2S: 419.14 [M+H]+; found: 420.1.

The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Application In Synthesis of 1-Methyl-1H-pyrazol-4-amine hydrochloride

Synthesis of Compound 1-8. Into a 25-mL round-bottom flask, was placed 8.5 (50 mg, 0.15 mmol, 1.00 equiv), l-methyl-lH-pyrazol-4-amine hydrochloride (30 mg, 0.22 mmol, 1.50 equiv), K3P04 (99 mg, 0.45 mmol, 3.00 equiv), Xphos-Pd (13 mg, 0.10 equiv) in tert-butanol (5 mL). The resulting solution was stirred for 4 h at 80 C. The resulting mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with dichloromethane/methanol (20: 1). This resulted in 34 mg (58%) of 1-8 as a yellow solid. LC-MS (ESI, m/z): 398 (M+H+); MR (300 MHz, CD3OD) delta 8.62 (s, 1H), 7.94 (s, 1H), 7.86 (s, 1H), 7.65 (s, 1H), 4.24 (m, 1H), 3.98 (m, 4H), 3.89 (s, 3H), 3.42 (s, 4H), 2.34 (m, 4H), 1.53-1.76 (m, 4H).

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Related Products of 118430-74-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118430-74-3, name is 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 168 Synthesis of N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indol-1-amine (Cpd. No. 255) In a round bottom flask, 4-(1-chloro-8-methoxy-5H-pyrido[4,3-b]indol-7-yl)-3,5-dimethylisoxazole (10 mg, 0.03 mmol), 3-cyclopropyl-1-methyl-1H-pyrazol-5-amine (9.06 mg, 0.06 mmol) and sodium tert-butoxide (11.5 mg, 0.12 mmol) were dissolved in dry toluene (10 mL). A solution of Pd2(dba)3 (10.8 mg, 0.012 mmol) and Dave Phos (9.4 mg, 0.024 mmol) in dry toluene (5 mL) was heated to reflux for 5 mins in a two-neck container before it was transferred into the round bottom flask by needle syringe. The resulting mixture was vacuumed and protected with nitrogen balloon, and heated to reflux overnight. As the reaction reach completion, the system were acidified with trifluoroacetic acid and concentrated in vacuum. The residue were dissolved in MeOH/H2O (3:1) system, filtered and purified by prep-HPLC. The product was lyophilized to give the title compound as a color-less powder (2.4 mg, yield 18.7%). 1HNMR (300 MHz, MeOD-d4) delta 8.01 (s, 1H), 7.80 (d, 1H, J=7.2 Hz), 7.56 (s, 1H), 7.37 (d, 1H, J=7.2 Hz), 6.24 (s, 1H), 3.98 (s, 3H), 3.80 (s, 3H), 2.36 (s, 3H), 2.19 (s, 3H), 2.00 (m, 1H), 1.00 (m, 2H), 0.81 (m, 2H). ESIMS m/z [M+H]+ calcd.=429.49. found=430.17.

The synthetic route of 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 632365-54-9, name is Methyl 5-amino-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 5-amino-1H-pyrazole-3-carboxylate

[00126] delta-Amino-S-pyrazolcarboxylic acid methyl ester (16.91 g, 119.8 mmol) is dissolved in ethanol (2.4 L) and hydrochloric acid (37%, 12.5 ml_, 150 mmol) is added. Then, a solution of 2-bromo-malonaldehyde (18.9 g, 125.2 mmol) in ethanol (1.4 L) and is quickly added in a dropwise manner at RT. After 30 min, a precipitation is observed; after 6 hours the precipitate is filtered and washed with 50 mL ethanol and thereafter with 50 mL diethyl ether to give 4.19 g of 6-bromo-pyrazolo[1 ,5a]pyrimidine-2-carboxylic acid methyl ester. After evaporation of the filtrate and crystallisation, an additional 1.43 g of product is obtained. Totally 5.62 g (18.3 %).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-12-0, name is 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O

To a solution of l,3-dimethyl-li/-pyrazole-4-carbaldehyde (1.00 g, 8.06 mmol) in nitromethane (35 mL) was added ammonium acetate (0.155 g, 2.01 mmol). The reaction mixture was heated at reflux overnight. Excess nitromethane was removed under reduced pressure. The residue was purified by automated flash silica column chromatography (40 g column) eluting with a gradient of 20-50% EtOAc in heptanes. The fractions were evaporated to give the title compound as a yellow solid (1.31 g, 97%). ESI-MS [M+H]+ calc?d for C7H9N3O2, 168.08; found, 168.2.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 313735-62-5, name is 4-Bromo-1-isopropylpyrazole, A new synthetic method of this compound is introduced below., Computed Properties of C6H9BrN2

4-bromo-1-(isopropyl)-1H-pyrazole (551 mg, 2.91 mmol) was dissolved in dry THF (7 mL) at -78 C under nitrogen and was stirred for 10 min. n-BuLi (2.5 M in hexanes, 1.45 mL, 3.06 mmol) was added drop wise to the solution was stirred for 2 h at -78 C. After two hours, ethyl fluoroacetate (0.33mL, 3.49 mmol) was added drop wise and stirred for 1 min at -78 C upon which the mixture was then quenched with NH4Cl (20 mL) and warmed to room temp. The mixture was then extracted with ether (50 mL), and dried over MgSO4. After concentration in vacuo (note: removeshortly after the ether is removed, because the compound is quite volatile), the residue waspurified with flash chromatography over silica gel (hexane: ethyl acetate = 80:20) to yield theproduct as a yellow solid in 20% yield (0.10 g)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 103626-03-5, name is Ethyl 1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 103626-03-5

Reference Example 37 A mixture of ethyl3-hydroxy-1-methyl-lH-pyrazole-4- carboxylate (25.50 g), benzyl bromide (17.8 ml), potassium carbonate (31.10 g) and N, N-dimethylformamide (250 ml) was stirred overnight at50 C. The reaction mixture was poured into water, and extracted with ethyl acetate. The ethyl acetate layer was washed with dilute hydrochloric acid and then with saturated aqueous sodium chloride solution, dried(MgS04) and concentrated. The residue was subjected to silica gel column chromatography, and ethyl3-benzyloxy-l-methyl-lH- pyrazole-4-carboxylate (31.90 g, yield82%) was obtained as colorless crystals from a fraction eluted with ethyl acetate- hexane (1: 1, volume ratio). The crystals were recrystallized from ethyl acetate-hexane. melting point:66-67 C.

The synthetic route of 103626-03-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5744-56-9, name is 1,3-Dimethyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

The 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide was prepared from 3-nitrobenzoyl chloride using the following multiple step procedure: Step 1: 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide.; A dry 250 mL flask was charged with 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid (0.989 g, 7.057 mmol) and thionyl chloride (5 mL) and allowed to stir at 79 C. for 2 h. The thionyl chloride was then removed by concentration in vacuo. The crude acid chloride was cooled to room temperature, and then dissolved in THF (40 mL). 6-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one (as prepared in Example 40, 1.26 g, 4.994 mmol) was added to the THF solution of the acid chloride, and the mixture was allowed to reflux for 4 h. The reaction mixture was then allowed to cool to room temperature. The room temperature reaction mixture was concentrated in vacuo. The solid residue was suspended in boiling EtOAc. The suspension was allowed to cool to room temperature before filtering to afford the 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide as a tan solid (1.4 g, 3.74 mmol, 75%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 3463-30-7, These common heterocyclic compound, 3463-30-7, name is 1-(4-Nitrophenyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a typical reaction, 5.0 mg of Pd-gCN (5.0 wtpercent of Pd) catalyst was added to the solution of 1.0 mM of nitroarene in ethanol (2 mL)and 2 mM (1.2 equiv. 0.07 mL) of 60percent of hydrazine hydrate. The mixture was placed into a 10 mL round-bottom flask at the reflux temperature (70¡ã C) for the 4 h and then allowed to cool at room temperature. The resultant material was filtered and the filtrate was subjected to column chromatography over silica gel to obtain the corresponding products. For di-nitroarenes substrates 4.0 mM(2.4 equiv. 0.14 mL) of 60percent of hydrazine hydrate solution was used.

The synthetic route of 3463-30-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 89088-55-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89088-55-1, name is 5-Bromo-1-methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of tert-butyl ((1 r,4r)-4-(bi s(tert-butoxycarbonyl)amino)cyclohexyl)(8 – ethyl-6-(4,4, 5,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)quinazolin-2-yl)carbamate (900 mg, 1.2 mmol), 5-bromo-i-methyl-1H-pyrazol-3-amine (227 mg, 1.2 mmol), K2C03 (536 mg, 3.9 mmol) and Pd(dppf)C12 (95 mg, 129.2 umol) in dioxane (4.0 mL) and H20 (400 uL) was degassed and purged with N2 for 3 times, and then the mixture was stirred at 90C for 12 h under N2 atmosphere. The reaction was concentrated to give a residue. The residue was purified by column chromatography (Si02, Petroleum ether / Ethyl acetate = 10/i to 0/i) to afford tert-butyl (6-(3 -amino-i-methyl-i H-pyrazol-5 -yl)-8 -ethylquinazolin-2-yl)(( 1 r,4r)-4-(bis(tert- butoxycarbonyl)amino)cyclohexyl)carbamate (590 mg, crude).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.