Related Products of 92933-47-6, A common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, molecular formula is C7H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of HATU (174.17 mg, 0.459 mmol) and 3-isopropylpyrazole-5-carboxylic acid (59.85 mg, 0.388 mmol) in DMF (2 mL) was then added diisopropylethylamine (92 muL, 0.529 mmol). The reaction solution was stirred at room temperature for 2 h. The N-(3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)benzamide (100 mg, 0.353 mmol) was added in one portion. The solution was then stirred at room temperature overnight. The reaction was diluted with methylene chloride and washed. The aqueous layer was extracted with methylene chloride twice, the combined organic phases were dried over anhydrous MgSO4. After evaporation of the solvent and recrystallization from ethyl acetate, filtered and dried to give desired compound (50 mg, 34%). 1H NMR (300 MHz, DMSO-d6) ppm 13.00 (s, 1H), 11.93 (s, 1H), 7.98 (d, J = 7.40 Hz, 2H), 7.67 (t, J = 7.15 Hz, 1H), 7.59 (t, J = 7.47 Hz, 2H), 6.40 (s, 1H), 5.18 (br. s., 0.9H), 4.75 (br. s., 1.1H), 4.20 (br. s., 1.2H), 3.93 (br. s., 0.8H), 2,91-3.10 (m, 1H), 2.78 (br. s., 2H), 1.25 (d, J = 5.7 Hz, 6H). 13C NMR (101 MHz, DMSO-d6) ppm 166.7, 164.5, 146.7, 147.0, 139.5, 139.2, 133.3, 132.7, 131.0, 128.8, 125.9, 114.3, 104.1, 95.6, 44.0, 41.5, 25.6, 25.4 22.7. LC/MS (ESI+, MeCN/H2O): m/z: calcd for C22H21N5O2S: 419.14 [M+H]+; found: 420.1.
The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.