Category: 313735-62-5

Application of 313735-62-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 313735-62-5, name is 4-Bromo-1-isopropylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-bromo-l- (propan-2-yl)-lH-pyrazole (2 g, 10.58 mmol, 1.00 equiv) in Et20 (20 mL) maintained under nitrogen at -78 C was added dropwise a 2.5 M n-butyllithium solution (4.6 mL) in hexane. The reaction mixture was stirred at -78 C for 1 h. Sulfur dioxide gas was then bubbled in for 30 min. The reaction mixture was stirred at -78 C for 30 min and then warmed to rt. The solid was collected by filtration, washed with Et20 and dried in a vacuum to give 0.9 g (47%) of the title compound as a white solid. LCMS (Method G, ESI): RT =1.03 min, m/z = 191.0.

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-isopropylpyrazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; DRAGOVICH, Peter; ZAK, Mark; ZHAO, Guiling; ZHENG, Xiaozhang; WO2014/74715; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 313735-62-5, name is 4-Bromo-1-isopropylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 313735-62-5, COA of Formula: C6H9BrN2

n–Butyllithium (2.5M in hexanes, 1.38 mL, 3.45 mmol) was added over 15 min to a solution of 4-bromo-1-isopropyl-1H-pyrazole (500 mg, 2.65 mmol) in diethyl ether (10 mL) at -78 C. After 30 min, a solution of tri-n-butylstannane chloride (920 muL, 3.45 mmol) in diethyl ether (1 mL) was added and the resultant reaction mixture was left to stir at -78 C for 1 h, then allowed to warm to ambient temperature. The reaction mixture was diluted with diethyl ether (40 mL) and washed with water (20 mL), then brine (20 mL). The organic layer was separated, dried over sodium sulfate, filtered and evaporated in vacuo to afford the title product as a colourless oil (98 mg, 94%) which was used without further purification. 1H-NMR (CDCl3, 400MHz): 7.46- 7.42 (m, 1 H); 7.28 (t, J = 4.2Hz, 1 H); 4.59-4.43 (m, 1 H); 1.58-1.42 (m, 12 H); 1.39-1.24 (m, 6 H); 1.02-0.77 (m, 15 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-isopropylpyrazole, and friends who are interested can also refer to it.

Reference:
Patent; GENENTECH, INC.; WO2009/151598; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 313735-62-5, name is 4-Bromo-1-isopropylpyrazole, A new synthetic method of this compound is introduced below., Computed Properties of C6H9BrN2

4-bromo-1-(isopropyl)-1H-pyrazole (551 mg, 2.91 mmol) was dissolved in dry THF (7 mL) at -78 C under nitrogen and was stirred for 10 min. n-BuLi (2.5 M in hexanes, 1.45 mL, 3.06 mmol) was added drop wise to the solution was stirred for 2 h at -78 C. After two hours, ethyl fluoroacetate (0.33mL, 3.49 mmol) was added drop wise and stirred for 1 min at -78 C upon which the mixture was then quenched with NH4Cl (20 mL) and warmed to room temp. The mixture was then extracted with ether (50 mL), and dried over MgSO4. After concentration in vacuo (note: removeshortly after the ether is removed, because the compound is quite volatile), the residue waspurified with flash chromatography over silica gel (hexane: ethyl acetate = 80:20) to yield theproduct as a yellow solid in 20% yield (0.10 g)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 313735-62-5, name is 4-Bromo-1-isopropylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 313735-62-5, SDS of cas: 313735-62-5

To a degassed (N2 bubbling) solution of the compound of Intermediate Example 12(a) 4-bromo-1-isopropyl-1H-pyrazole (1.5 g, 7.9 mmol) in 1,4-dioxane (30 ml) were added 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (3 g, 11.84 mmol, 1.5 eq.), Pd(dppf)Cl2 (0.64 g, 0.79 mmol, 0.1 eq.) and potassium acetate (1.93 g, 19.74 mmol, 2.5 eq.) using the procedure of Intermediate Example 1(b). The solvent was distilled off to afford the product in 67% yield (1.2 g). LC-MS (ESI): Calculated mass: 236.12; Observed mass: 237.1 [M+H]+ (rt: 1.41 min).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-isopropylpyrazole, and friends who are interested can also refer to it.

Electric Literature of 313735-62-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 313735-62-5 name is 4-Bromo-1-isopropylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-bromo-1-(isopropyl)-1H-pyrazole 11d (200 mg, 1.06 mmol) was dissolved in dry THF (6 mL) at -78 Cunder nitrogen and was stirred for 10 min. n-BuLi (2.5 M in hexanes, 0.44 mL, 1.11 mmol) was added drop wise to the solution was stirred for 2 h at -78 C. After two hours, ethyl difluoroacetate (0.11 mL, 1.27 mmol) was added drop wise and stirred for 10 min at -78 C uponwhich the mixture was then quenched with NH4Cl (20 mL) and warmed to room temp. Themixture was then extracted with ether (50 mL), and dried over MgSO4. After concentration invacuo (note: remove shortly after the ether is removed, because the compound is quite volatile),the residue was purified with flash chromatography over silica gel (hexane: ethyl acetate =80:20) to yield the product as a clear oil in 48% yield (0.1 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-isopropylpyrazole, and friends who are interested can also refer to it.