Tag: M.W:100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C4H4N4

Following the procedure described in Example 1 wherein propanol was used as the solvent instead of ethanol, 86percent of the product was obtained with m. p. 185-188 ¡ãC.

The synthetic route of 16617-46-2 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 79080-39-0, These common heterocyclic compound, 79080-39-0, name is 1-Methyl-1H-pyrazole-3-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 1 -methyl-1 H-pyrazole-3-carbonitrile (2.7 g, 25.2 mmol) in Et20 (150 mL) cooled in ice bath was added LiAIH4 (27.7 mL, 55.5 mmol, 2M in THF) slowly, and the reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction was then cooled in ice bath and quenched by sequential addition of water (4 mL), 15percentNaOH solution (4 mL), and water (12 mL). The mixture was then stirred for 15 minutes, and the resulting solid was filtered. The filtrate was dried over MgS04 and concentrated to afford (1 -methyl- 1 H-pyrazol-3-yl)methanamine (1 .28 g) as a clear oil. LC-MS (ES) m/z = 1 12 [M+H]+. 1H NMR (400 MHz, DMSO-c/6): delta 1 .69 (br. s, J = 1 .5 Hz, 2H), 3.60 (s, 2H), 3.75 (s, 3H), 6.12 (d, J = 2.0 Hz, 1 H), 7.53 (d, J = 2.0 Hz, 1 H).

Statistics shows that 1-Methyl-1H-pyrazole-3-carbonitrile is playing an increasingly important role. we look forward to future research findings about 79080-39-0.

Related Products of 52222-73-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

3-(3-(4-(chloromethyl)benzyl)isoxazol-5-yl)pyridin-2 -amine (Intermediate B, 80mg, 0.27mmol) and 4-(trifluoromethyl)-lH-pyrazole (l45mg, l .07mmol) were dissolved in NMP (lml). Potassium 2- methylpropane-2-olate (1M in THF, 0.80mL, 0.80mmol) was added and the mixture was stirred for 5min at 60C. The cooled reaction mixture was directly purified by column chromatography (Si02, hexane/ethyl acetate). Fraction containing the product were concentrated under reduced pressure and further purified by HPLC to yield 3-(3-(4-((4-(trifluoromethyl)-lH-pyrazol-l-yl)methyl)benzyl)isoxazol- 5-yl)pyridin-2-amine (75mg, 0. l9mmol, 70%) as a white solid. 400 MHz ‘H NMR (CDC13) d 8.14 (d, ./ = 3.7 Hz, 1H), 7.73 (s, 1H), 7.69 (dd, J= 7.7, 1.8 Hz, 1H), 7.64 (s, 1H), 7.30 (d, J= 8.2 Hz, 2H), 7.22 (d, J = 8.2 Hz, 2H), 6.70 (dd, J= 7.7, 4.9 Hz, 1H), 6.25 (s, 1H), 5.43 (s, 2H), 5.29 (s, 2H), 4.05 (s, 2H). MS: 400.3 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Related Products of 14531-55-6, A common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, molecular formula is C5H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Lambda -(1 -(2-Hydroxyethyl)-3,5-dimethyl-1 H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamideStep 1 : To a solution of 3,5-dimethyl-4-nitro-1 H-pyrazole (500 mg, 3.52 mmol) in MeCN (5 ml_), Cs2C03 (1.26 g, 3.87 mmol) and 2-bromoethanol (0.3 ml_, 4.21 mmol) was added. The resulting mixture was refluxed (90 C) for 3 h, then the reaction mixture was allowed to reach rt. The mixture was diluted with DCM, filtered, the filter cake rinsed with DCM and the filtrate concentrated in vacuo. The residue was partitionned between water and EtOAc, the org. layer was separated and the aq. layer was extracted with EtOAc (1x). The combined org. layers were washed with brine, dried (MgS04), filtered and concentrated in vacuo to yield 2- (3,5-dimethyl-4-nitro-1 H-pyrazol-1-yl)ethanol as a white solid. LC-MS conditions A: tR = 0.53 min, [M+H]+= 186.39

The synthetic route of 14531-55-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 5744-40-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5744-40-1 as follows.

A suspension of Step 1 intermediate (5.3 g, 31.52 mmol) in aqueous sodium hydroxide (5%, 32 mL) was refluxed for 4 h. The reaction mixture was cooled to 0 C and acidified with cone. HQ till pH 2-3. The precipitated solid was filtered and dried well to obtain 3.67 g of the desired product. lH NMR (300 MHz, CDC13): delta 3.87 (s, 3H), 4.13 (s, 3H), 6.61 (s, 1H), 6.71 (s, 1H).

According to the analysis of related databases, 5744-40-1, the application of this compound in the production field has become more and more popular.

Reference of 25016-11-9, A common heterocyclic compound, 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of the combined organic layer having 1-methyl-1H-pyrazole-4-carbaldehyde and ethyl acetate obtained from step 1, hydroxylamine hydrochloride (63.48 gm, 0.9135 moles) were refluxed at 70-80 C. for 2-4 hours. The progress of the reaction was monitored by HPLC. The reaction mixture was cooled to 0-5 C., to this added DM water (100 ml) and 25% aqueous ammonia solution (100 ml) at 0-5 C. The reaction mixture was stirred for 10 min at 20-30 C. The organic layer was separated and aqueous layer was extracted with ethyl acetate (250 ml). The entire organic layer was transferred to the reaction vessel and washed with 10% brine solution (500 ml). Stirred for 10 min and separated the final aqueous layer and organic layer. The organic layer was evaporated to obtain the 1-methyl-1H-pyrazole-4-carbaldehyde oxime.

The synthetic route of 25016-11-9 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 400755-41-1, name is 3-Methoxy-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H5N3O3

To a suspension of 3-methoxy-4-nitro-1H-pyrazole (2.00 g, 14.0 mmol, 1.00 eq), (R)-1-methyl-pyrrolidin-3-ol (1.56 g, 15.4 mmol, 1.10 eq), and polystyrene bound triphenylphosphine (6.53 g, 19.6 mmol, 1.40 eq, 3 mmol/gram) in THF (140 mL) was added a solution of di-tert-butyl azodicarboxylate (4.51 g, 19.6 mmol, 1.40 eq) in THF (25 mL) in a drop-wise manner over 5 min. The reaction mixture was allowed to stir for 18 hr. The reaction mixture was then diluted with EtOAc (100 mL), filtered and the filtrate concentrated. The crude reaction mixture was purified via flash chromatography on silica gel eluting with a gradient of 50-100% EtOAc in heptane then to 10% 7 N methanolic ammonia/EtOAc to give the title compound (2.39 g, 80% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 8.69 (s, 1H), 4.84-4.72 (m, 1H), 3.94 (s, 3H), 2.86-2.75 (m, 2H), 2.72 (dd, J=7.0, 10.0 Hz, 1H), 2.40 (dt, J=6.2, 8.4 Hz, 1H), 2.36-2.29 (m, 1H), 2.28 (s, 3H), 2.16-2.06 (m, 1H). m/z (APCI+) for C9H15N4O3 227.2 (M+H)+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 400755-41-1.

Application of 37718-11-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37718-11-9, name is 1H-Pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 6.1. 1 -(tetrahydro-2H-pyran-2-yl)-1 H-pyrazole-4-carboxylic acid To a suspension of 1 /-/-pyrazole-4-carboxylic acid (50 g, 446 mmol) in 500 mL of DMF are added para-toluenesulfonic acid (8.48 g, 44 mmol) and DHP (132 mL, 1561 mmol). The reaction medium turns yellow and then black after stirring at room temperature for 20 hours. The reaction mixture is poured into saturated aqueous NaHC03 solution and extracted with EtOAc. The aqueous phase is acidified to pH 3 by adding 6M hydrochloric acid solution. The precipitate formed is filtered off and washed with water and then dried under vacuum at 50C to give 61.2 g of a white powder (yield: 70%). LCMS (Method D): MH+ = 197.1 , RT = 0.60 min

The synthetic route of 1H-Pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3524-32-1 as follows. Quality Control of 5-Amino-1,3-dimethylpyrazole

Step 1 N-(2,5-Dimethyl-2H-pyrazol-3-yl)-2,2-dimethyl-propionamide To 15.0 g (131 mmol) N-(2,5-dimethyl-2H-pyrazol-3-yl)-amine in 150 mL pyridine at 0 C. was added 19.3 mL (18.9 g, 158 mmol) of pivaloyl chloride. After stirring at 23 C. for 3.5 hours, the reaction solvent was evaporated, and the residue was evaporated with 2*200 mL toluene. The remaining solid was dissolved in 500 mL EtOAc/200 mL H2O and extracted. The aqueous layer was extracted with 2*100 mL EtOAc, and the combined organics were washed with 1*200 mL brine, dried over MgSO4, filtered and evaporated to an orange solid. Recrystallization from hot hexanes/EtOAc gave 24.45 g (125 mmol, a 96% yield) of the title compound as an off-white, crystalline solid: mp: 86-88 C.; 1H NMR (300 MHz, CDCl3): delta 1.32 (s, 9H), 2.22 (s, 3H), 3.63 (s, 3H), 5.98 (s, 1H), 7.12 (brs, 1H); IR (KBr, cm-1): 3316s, 3274s, 2967m, 2935m, 1673s, 1655m, 1570s, 1514m, 1492m, 1457m; MS (ES) m/z (relative intensity): (196, M+, 100). Anal. Calcd. for C10H17N3O: C, 61.51; H, 8.77; N, 21.52. Found: C, 61.33; H, 8.80; N, 21.23.

According to the analysis of related databases, 3524-32-1, the application of this compound in the production field has become more and more popular.

Related Products of 1310350-99-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1310350-99-2 name is 4-Chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide The title compound was prepared according to Method AA starting from 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid (WO201169934). MS m/z=196 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.