Reference of 25016-11-9, A common heterocyclic compound, 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of the combined organic layer having 1-methyl-1H-pyrazole-4-carbaldehyde and ethyl acetate obtained from step 1, hydroxylamine hydrochloride (63.48 gm, 0.9135 moles) were refluxed at 70-80 C. for 2-4 hours. The progress of the reaction was monitored by HPLC. The reaction mixture was cooled to 0-5 C., to this added DM water (100 ml) and 25% aqueous ammonia solution (100 ml) at 0-5 C. The reaction mixture was stirred for 10 min at 20-30 C. The organic layer was separated and aqueous layer was extracted with ethyl acetate (250 ml). The entire organic layer was transferred to the reaction vessel and washed with 10% brine solution (500 ml). Stirred for 10 min and separated the final aqueous layer and organic layer. The organic layer was evaporated to obtain the 1-methyl-1H-pyrazole-4-carbaldehyde oxime.
The synthetic route of 25016-11-9 has been constantly updated, and we look forward to future research findings.