Category: 79080-39-0

Synthetic Route of 79080-39-0, These common heterocyclic compound, 79080-39-0, name is 1-Methyl-1H-pyrazole-3-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 1 -methyl-1 H-pyrazole-3-carbonitrile (2.7 g, 25.2 mmol) in Et20 (150 mL) cooled in ice bath was added LiAIH4 (27.7 mL, 55.5 mmol, 2M in THF) slowly, and the reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction was then cooled in ice bath and quenched by sequential addition of water (4 mL), 15percentNaOH solution (4 mL), and water (12 mL). The mixture was then stirred for 15 minutes, and the resulting solid was filtered. The filtrate was dried over MgS04 and concentrated to afford (1 -methyl- 1 H-pyrazol-3-yl)methanamine (1 .28 g) as a clear oil. LC-MS (ES) m/z = 1 12 [M+H]+. 1H NMR (400 MHz, DMSO-c/6): delta 1 .69 (br. s, J = 1 .5 Hz, 2H), 3.60 (s, 2H), 3.75 (s, 3H), 6.12 (d, J = 2.0 Hz, 1 H), 7.53 (d, J = 2.0 Hz, 1 H).

Statistics shows that 1-Methyl-1H-pyrazole-3-carbonitrile is playing an increasingly important role. we look forward to future research findings about 79080-39-0.

Synthetic Route of 79080-39-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 79080-39-0, name is 1-Methyl-1H-pyrazole-3-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: LiH (35 mg, 4.44 mmol) was added to a stirring glyme (20 mL) solution of arachno-4,6-C2B7H13 (500 mg, 4.44 mmol) under N2 at room temperature. The solution was monitored by NMR until ?95% complete. The solution was then filtered through a frit under N2 to remove excess LiH. A glyme solution of 2,3,4,5,6-pentafluorobenzonitrile (2.8 mL, 22.2 mmol in 20 mL glyme) was added via syringe. The reaction mixture was stirred at reflux for 12 h, then cooled and filtered through a frit under N2. The resulting Li+[6-C6F5-nido-5,6,9-C3B7H9-] was not isolated, but instead stored as a stock solution until use. The concentration of the solution and the yield (81%, 0.09M) were determined by integrating the resonances in the 11B NMR spectrum of a B10H14 sample of known concentration and comparing that value with the integrated value of the resonances of the stock solution.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazole-3-carbonitrile. I believe this compound will play a more active role in future production and life.

Application of 79080-39-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 79080-39-0 name is 1-Methyl-1H-pyrazole-3-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of 5-methyl-3-(1-methylpyrazol-3-yl)-1,2,4-oxadiazole (72): To a suspension of hydroxylamine hydrochloride (351 mg, 5.05 mmol) in 4 ml EtOH was added 1.86 ml 21% wt sodium ethoxide in ethanol. The resulting mixture was stirred for 10 min at r.t. before addition of 3-cyano-1-methylpyrazole (70) (535 mg, 5 mmol). The resulting suspension was heated overnight at 90 C. After cooling down, the reaction mixture was diluted with EA then washed with brine. Org. phase was concentrated to dryness to give 506 mg crude intermediate 71. A mixture of the above crude intermediate 71, trifluoromethanesulfonic acid Ytterbium (III) salt (22 mg, 1% mol) and trimethyl orthoacetate (550 mul, 1.2 eq.) in 5 ml EtOH was heated at 85 C. for 2 h. After cooling down to r.t., fine needles formed. After filtration and wash with MeOH 166 mg intermediate 71 was recovered as pale yellow needles. The filtrate was concentrated, subjected to silica gel column purification using 0-100% B (A: hexane; B: EA) to furnish 230 mg 5-methyl-3-(1-methylpyrazol-3-yl)-1,2,4-oxadiazole (72) as white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-3-carbonitrile, and friends who are interested can also refer to it.