Tag: M.W:100-200

Some common heterocyclic compound, 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, molecular formula is C5H5N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 138786-86-4

A mixture of sodium hydride (167 mg, 6. [96] mmol) in tetrahydrofuran (15 mL) cooled to [0 oC] was treated with a solution [OF 4-NITRO-LH-PYRAZOLE-3-CARBOXYLIC] acid methyl ester (1.0 g, 5.8 mmol) in tetrahydrofuran (10 mL). This mixture was stirred at [0 oC] for 1 h. It was then treated with methyl iodide (0.54 mL, 8.7 mmol). The reaction was stirred at [25 oC] for 18 h. At this time, the reaction was cooled to 0 oC and was then quenched with a saturated aqueous ammonium chloride solution and diluted with ethyl acetate (200 mL). This solution was washed with water (1 x 100 mL) and a saturated aqueous sodium chloride solution (1 x 100 mL). The organics were dried over magnesium sulfate, filtered, and concentrated in vacuo. The resulting solid was slurried in 40% ethyl acetate/petroleum ether and cooled in the freezer for 15 min. At this time, the solids were collected by filtration to afford [L-METHYL-4-NITRO-LH-] pyrazole-3-carboxylic acid methyl ester (889 mg, 82.8%) as a white solid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 138786-86-4, its application will become more common.

Synthetic Route of 10010-93-2, A common heterocyclic compound, 10010-93-2, name is 3-Methyl-5-(trifluoromethyl)-1H-pyrazole, molecular formula is C5H5F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00143] Step 1: A mixture of 2-chloro-l-(l-(4-chloro-3-methoxyphenyl)piperidin- 4-yl)ethanone (580 mg, 1.919 mmol; see Example Ia, Step 2), 5-methyl-3- (trifluoromethyl)-lH-pyrazole (576 mg, 3.84 mmol), potassium carbonate (796 mg, 5.76 mmol) and acetonitrile (20 mL) was stirred at RT for 12 h. After this time, the solvent was removed under reduced pressure and the resultant residue was partitioned between EtOAc (10OmL) and water (50 mL). The organic phase was washed with brine, dried (TS^SO4) and concentrated on a rotary evaporator to yield a residue. The residue was purified by flash chromatography using a 40 g silica gel cartridge and gradient elution from 10: 1 Hex/EtOAc to 1 : 1 Hex/EtOAc. The fractions containing the product were pooled and concentrated on a rotary evaporator to give l-(l-(4- chloro-3-methoxyphenyl)piperidin-4-yl)-2-(5-methyl-3-(trifluoromethyl)-lH-pyrazol- l-yl)ethanone (650 mg, 1.563 mmol, 81 % yield) as clear oil. 1H-NMR (400 MHz, CDCl3) delta ppm 7.19 (1 H, d, J=8.57 Hz), 6.49 (1 H, d, J=2.42 Hz), 6.44 (1 H, dd, J=8.68, 2.53 Hz), 6.35 (1 H, s), 5.01 – 5.04 (2 H, m), 3.84 – 3.89 (3 H, m), 3.62 – 3.69 (2 H, m), 2.77 (2 H, td, J=12.03, 2.75 Hz), 2.58 (1 H, tt, J=I 1.29, 3.87 Hz), 2.21 (3 H, s), 1.99 (2 H, s), 1.80 – 1.91 (2 H, m).

The synthetic route of 10010-93-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 852443-61-9, name is 3-(Trifluoromethyl)-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 852443-61-9, HPLC of Formula: C4H4F3N3

-((2-Chloro-4-fluorobenzyl)carbamothioyl)-3,4-difluorobenzamide (98.0 g, 273 mmol) and 5-amino-3-trifluoromethylpyrazole (41.3 g, 273 mmol) were dissolved in THF (546 mL). Nl-((Ethylimino)methylene)-N3,N3-dimethylpropane-l,3-diamine hydrochloride (57.6 g, 300 mmol) was added and the reaction was stirred at room temperature for 1 h and then heated to 40 C for 15 h. The crude mixture was diluted with water (500 mL) and isopropyl acetate (500 mL). The organic layer was washed with brine (500 mL), dried over sodium sulfate, and concentrated. The residue was diluted with isopropyl acetate (1.3 L) and heated to 65 C for 1 hour. The solution was allowed to cool to room temperature, filtered and the filtrate was concentrated. The residue was heated to70C in acetonitrile (900 mL) and then allowed to cool to room temperature. The resulting suspension was filtered, rinsed with acetonitrile (200 mL) and dried in vacuo at 60C to afford 55 g (43%) of (Z)-N-(((2-chloro-4- fluorobenzyl)amino)((3-(trifluoromethyl)-lH-pyrazol-5-yl)amino)methylene)-3,4- difluorobenzamide as a white solid. 1HNMR (400 MHz, MeOH-d4) delta 7.95 (bs, 2H), 7.50 (t, 1H, J=7.2Hz), 7.26 (m, 2H), 7.06 (t, 1H, J=7.5 Hz), 6.56 (s, 1H), 4.84 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.

Related Products of 110860-60-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110860-60-1, name is Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

(5) Synthesis of alpha-Type Crystal Morphology Azo Pigment Compound (2) (9.2 g) was dissolved in a mixed solution of 55 mL of acetic acid and 37 mL of propionic acid at room temperature, and the resulting solution was ice-cooled to lower the internal temperature to -3 C. A 40 mass % sulfuric acid solution of nitrosylsulfuric acid was added dropwise at an internal temperature of -3 C. to 4 C. over 10 minutes and after stirring at an internal temperature of 4 C. for 1 hour, 0.2 g of urea was added. Thereafter, the internal temperature was lowered to -3 C., and the mixture was further stirred for 10 minutes to obtain a diazonium salt solution. Separately, 10 g of Compound (3) was completely dissolved in 150 mL of acetone. This solution was cooled to an internal temperature of 17 C. and then added to the diazonium salt solution obtained above, at an internal temperature of -3 C. to 3 C. over 25 minutes. After the completion of addition, the mixture was stirred at 3 C. for 30 minutes, and the ice bath was removed. The temperature was raised to room temperature over 30 minutes, and the resulting solution was stirred at room temperature for 30 minutes. The obtained crystal was collected by filtration, spray-washed with 150 mL of acetone and further spray-washed with 100 mL of water. The obtained crystal was without drying suspended in 400 mL of water, and an aqueous 8 N potassium hydroxide solution was added to adjust the pH to 5.7. The system was stirred at room temperature for 20 minutes, and the obtained crystal was separated by filtration, thoroughly spray-washed with water and spray-washed with 80 mL of acetone. The obtained crystal was dried at room temperature for 12 hours.Crystal 1 obtained was suspended in 580 mL of acetone, and the suspension was stirred under reflux for 30 minutes and then cooled to room temperature over 10 minutes. The obtained crystal was separated by filtration and dried at 60 C. for 5 hours to obtain 17.1 g of an azo pigment composition containing an azo pigment represented by formula (1) having the crystal form of the present invention. Yield: 88.5%. The particle size of the obtained azo pigment was measured with an eye by using a transmission microscope (electron microscope JEM-1010, manufactured by JEOL Ltd.), as a result, the length in the long axis direction of the primary particle was about 15 mum.The obtained crystal was an alpha-type crystal morphology azo pigment shown in FIG. 1 or a tautomer thereof, having characteristic X-ray diffraction peaks at Bragg angles (2theta+/-0.2) of 7.6, 25.6 and 27.7 in the CuKalpha characteristic X-ray diffraction but not having a peak at 7.0 and 6.4 (alpha-Type Crystal Morphology Azo Pigment Composition 1).

The synthetic route of Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Reference of 2644-93-1, These common heterocyclic compound, 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

At room temperature for 6-bromo-4-chloro-2-methoxy-3 – (4 – (trifluoromethyl) benzyl) quinoline (1.37 g, 3.86 mmol, Intermediate 10: step d) comprises that the flask, THF It was added (45 mL) to obtain a colorless, homogeneous mixture.Cooling the solution to -78 Next,ndropwise -BuLi (2.5 M, 1.8 mL, 4.5 mmol in hexane).The color of the solution was reddish brown.4 minutes after, 1,3,5-trimethyl -1H-pyrazole-4-carbaldehyde (300 mg, 2.17 mmol, 3 mL of THF) was introduced to he a mixture of red-brown color over 5 min It was in turn greenish yellow.The mixture was warmed to 0 over 45 minutes and, at this time the reaction NH4was quenched with aqueous solution of Cl.The mixture was diluted further with water and extracted with EtOAc (3 ¡Á 150 mL).The combined organics were washed with brine, MgSO4dried, filtered, and concentrated to give a light orange foam.Silica gel by FCC on (2% MeOH-DCM, increased to 8% MeOH-DCM), to give the title compound as a pale yellow non-crystalline solid.

The synthetic route of 2644-93-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1151802-23-1, name is 4-Bromo-1-cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1151802-23-1, Computed Properties of C6H7BrN2

A mixture of (2,6-dichlorophenyl)boronic acid (1.9 g, 10.1 mmol), 4-bromo-l- cyclopropyl-lH-pyrazole (1.7 g, 9.2 mmol), PdCl2(dppf)-CH2Cl2 adduct (0.30 g, 0.34 mmol) and Na2C03 (1.9 g, 18.4 mmol) in THF (15 mL) and water (5 mL) was degassed and then heated under microwave irradiation at 100 C for 3 hours. The reaction mixture was diluted with EtOAc, washed with saturated aqueous NH4CI and brine, dried over MgS04, filtered, and concentrated in vacuo. The residue was purified by flash chromatography on S1O2 (0-30% EtOAc/hexanes) to afford l-cyclopropyl-4-(2,6-dichlorophenyl)-lH-pyrazole (1.4 g, 5.5 mmol, 60% yield) as an oil which became solid upon standing. NMR (500 MHz, CDCh) delta 7.63 (s, 2H), 7.35-7.43 (m, 2H), 7.15 (t, J=7.98 Hz, 1H), 3.68 (tt, J=3.78, 7.36 Hz, 1H), 1.21 (dt, J=1.10, 3.03 Hz, 2H), 1.07 (dd, J=1.93, 7.15 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-cyclopropyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 114474-28-1 as follows. Product Details of 114474-28-1

To a solution of 2,4-dichloro-6-(2-methoxyethoxy)quinazoline (273 mg, 1.00 mmol) and 4-(4-aminophenyl)pyrazole amine (159 mg, 1.00 mmol) in DMF (2 mL) in a 1- dram vial was added DIEA (258 mg, 2.00 mmol, 0.348 mL). The mixture was heated at 100 C overnight. LC-MS showed one main peak corresponding to the desired product mass. The reaction mixture was cooled to rt and poured into water. The precipitate was filtered and washed with water. The resulting yellow solid was left to dry on the filter for 2 h to give 419 mg of crude product which was used as is in the next reaction. MS (ES+) m/e 396/398 (M+H)+.

According to the analysis of related databases, 114474-28-1, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H8N2O

3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoic acid (1 g) was dissolved in chloroform (20 mL), and oxalyl chloride (500 mg) was added. A catalytic amount of dimethylformamide was added, followed by stirring at room temperature for 3 hours. Then, the solvent was distilled off under reduced pressure. The obtained residue was dissolved in tetrahydrofuran (5 mL), and then a solution having 5-hydroxy-1 ,3-dimethylpyrazole (450 mg) dissolved in tetrahydrofuran (15 mL) was slowly added. Triethylamine (0.65 mL) was added, followed by heating and refluxing for 5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and poured into water, then acidified with dilute hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure. The obtained residue was dissolved in acetonitrile (20 mL), and under cooling in an ice bath, triethylamine (0.65 mL) and acetone cyanohydrin (100 mg) were added, followed by stirring at room temperature for 18 hours. The reaction solution was poured into water and washed with a small amount of ethyl acetate. Then, the aqueous layer was acidified with dilute hydrochloric acid. It was extracted with ethyl acetate, and then, the organic layer was washed with a saturated sodium chloride aqueous solution and then dried over magnesium sulfate. The solvent was distilled off 5 under reduced pressure. The obtained residue was purified by column chromatography (developing solvent: ethyl acetate) to obtain 5-hydroxy-1 ,3-dimethylpyrazol-4-yl 3-(2- methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl ketone (500 mg, the following Compound No. 5- 2) as slightly yellow solid.

The synthetic route of 1,3-Dimethyl-1H-pyrazol-5-ol has been constantly updated, and we look forward to future research findings.

Application of 612511-81-6, These common heterocyclic compound, 612511-81-6, name is (1-Methyl-1H-pyrazol-3-yl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5-bromo-2-chloro-3-nitropyridine (600 mg, 2.53 mmol) in CH3CN (12 mL) were added (1 -methyl-1 H-pyrazol-3-yl)methanamine (281 mg, 2.53 mmol) and N,N- diisopropylethylamine (0.530 mL, 3.03 mmol), and the reaction mixture was stirred at room temperature for 20 hours. The mixture was concentrated, and the resulting residue was washed with water and dried under vacuum to give the desired product (750 mg) as a pale yellow solid. LC-MS (ES) m/z = 312, 314 [M+H]+. NMR (400 MHz, CD3OD): delta 3.87 (s, 3H), 4.80 (d, J = 5.6 Hz, 2H), 6.25 (d, J = 2.3 Hz, 1 H), 7.52 (d, J = 2.3 Hz, 1 H), 8.51 (d, J = 2.3 Hz, 1 H), 8.63 (d, J = 2.3 Hz, 1 H).

The synthetic route of 612511-81-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175137-46-9, name: 5-Cyclopropyl-1H-pyrazol-3-amine

A solution of S-cyclopropyl-lH-pyrazol-S-amine (1.9g, 16.0 mmol) in CH3CN (20 ml) was added dropwise to a solution of 2,6-dichloro-5-fluoronicotinonitrile (3.0 g, 16.0 mmol) and triethylamine (2.1 g, 20.0 mmol) in CH3CN (80 ml) at 25 C. The resulting solution was heated to 82 0C for 18 hrs, and then cooled to 25 0C. The resulted precipitate was collected by filtration and washed with CH3CN (100 ml) to give the title compound (3.2 g, 73%). MS:Calcd.: 277; Found: [M+H]+ 278.

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