Some common heterocyclic compound, 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, molecular formula is C5H5N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 138786-86-4
A mixture of sodium hydride (167 mg, 6. [96] mmol) in tetrahydrofuran (15 mL) cooled to [0 oC] was treated with a solution [OF 4-NITRO-LH-PYRAZOLE-3-CARBOXYLIC] acid methyl ester (1.0 g, 5.8 mmol) in tetrahydrofuran (10 mL). This mixture was stirred at [0 oC] for 1 h. It was then treated with methyl iodide (0.54 mL, 8.7 mmol). The reaction was stirred at [25 oC] for 18 h. At this time, the reaction was cooled to 0 oC and was then quenched with a saturated aqueous ammonium chloride solution and diluted with ethyl acetate (200 mL). This solution was washed with water (1 x 100 mL) and a saturated aqueous sodium chloride solution (1 x 100 mL). The organics were dried over magnesium sulfate, filtered, and concentrated in vacuo. The resulting solid was slurried in 40% ethyl acetate/petroleum ether and cooled in the freezer for 15 min. At this time, the solids were collected by filtration to afford [L-METHYL-4-NITRO-LH-] pyrazole-3-carboxylic acid methyl ester (889 mg, 82.8%) as a white solid
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 138786-86-4, its application will become more common.