In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 114474-28-1 as follows. Product Details of 114474-28-1
To a solution of 2,4-dichloro-6-(2-methoxyethoxy)quinazoline (273 mg, 1.00 mmol) and 4-(4-aminophenyl)pyrazole amine (159 mg, 1.00 mmol) in DMF (2 mL) in a 1- dram vial was added DIEA (258 mg, 2.00 mmol, 0.348 mL). The mixture was heated at 100 C overnight. LC-MS showed one main peak corresponding to the desired product mass. The reaction mixture was cooled to rt and poured into water. The precipitate was filtered and washed with water. The resulting yellow solid was left to dry on the filter for 2 h to give 419 mg of crude product which was used as is in the next reaction. MS (ES+) m/e 396/398 (M+H)+.
According to the analysis of related databases, 114474-28-1, the application of this compound in the production field has become more and more popular.