Adding a certain compound to certain chemical reactions, such as: 852443-61-9, name is 3-(Trifluoromethyl)-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 852443-61-9, HPLC of Formula: C4H4F3N3
-((2-Chloro-4-fluorobenzyl)carbamothioyl)-3,4-difluorobenzamide (98.0 g, 273 mmol) and 5-amino-3-trifluoromethylpyrazole (41.3 g, 273 mmol) were dissolved in THF (546 mL). Nl-((Ethylimino)methylene)-N3,N3-dimethylpropane-l,3-diamine hydrochloride (57.6 g, 300 mmol) was added and the reaction was stirred at room temperature for 1 h and then heated to 40 C for 15 h. The crude mixture was diluted with water (500 mL) and isopropyl acetate (500 mL). The organic layer was washed with brine (500 mL), dried over sodium sulfate, and concentrated. The residue was diluted with isopropyl acetate (1.3 L) and heated to 65 C for 1 hour. The solution was allowed to cool to room temperature, filtered and the filtrate was concentrated. The residue was heated to70C in acetonitrile (900 mL) and then allowed to cool to room temperature. The resulting suspension was filtered, rinsed with acetonitrile (200 mL) and dried in vacuo at 60C to afford 55 g (43%) of (Z)-N-(((2-chloro-4- fluorobenzyl)amino)((3-(trifluoromethyl)-lH-pyrazol-5-yl)amino)methylene)-3,4- difluorobenzamide as a white solid. 1HNMR (400 MHz, MeOH-d4) delta 7.95 (bs, 2H), 7.50 (t, 1H, J=7.2Hz), 7.26 (m, 2H), 7.06 (t, 1H, J=7.5 Hz), 6.56 (s, 1H), 4.84 (s, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.