Tag: M.W:100-200

Related Products of 112758-40-4,Some common heterocyclic compound, 112758-40-4, name is 3-Methyl-1H-pyrazole-4-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of Example 13 (53 mg, 0.17 mmol, 1.0 eq) and 1-methyl-1H-imidazole-2-carbaldehyde (28 mg, 0.25 mmol, 1.5 eq) in THF (2 mL) under a N2 atmosphere was added NaBH(OAc)3 (72 mg, 0.34 mmol, 2.0 eq) and the mixture was stirred at RT overnight. The mixture was purified by C18 reverse phase column (Biotage, 30% to 70% ACN in water, 0.1% TFA) to afford the title compound (22 mg, 34%) as a white solid. LCMS: [M+H]+ 384.2. 1H NMR (400 MHz, CDCl3) delta 8.10 (d, J=8.4 Hz, 1H), 7.65 (d, J=7.2 Hz, 1H), 7.41 (s, 2H), 7.20 (s, 1H), 4.78 (s, 2H), 3.98 (s, 3H), 3.80 (s, 2H), 3.40 (m, 2H), 3.17-3.00 (m, 3H), 2.59 (s, 3H), 2.24 (m, 2H), 1.95 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methyl-1H-pyrazole-4-carbaldehyde, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 139756-02-8

General procedure: We intended to synthesize compounds based on 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one scaffold by using microwave assisted protocol (Scheme 1). In this direction we started the studies for optimization of synthesis of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 3a. The optimization studies were initiated by screening of different oxidizing agents as depicted in Table1, see Supplementary data using DMSO:Water in 1:1 proportion to see the conversion in desired product. Amongst all oxidants, the best result was observed with K2S2O8, in equivalence studies for catalyst, 3eq. of catalyst has given maximum yields (Table1, see Supplementary data). Therefore, all reactions were conducted using this condition after optimization of catalyst. However, oxone has also given the product 3a with minor yields. After screening of the catalyst we started study of selectivity for solvent that could affect the formation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 3a. The solvent screening was carried out to find out the best conversion, the mixture of DMSO:H2O in 1:1 proportion has given the best results with excellent yields (Table2, see Supplementary data). The microwave protocols were optimized for this reaction as mentioned in Table 3, see Supplementary data; the reactions carried under different microwave Watt powers have given varied results. Wherein, entry 3(b) (Table3, see Supplementary data) was found to be the best condition for maximum conversion. A series of compounds based on 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one scaffold was synthesized using these optimized conditions, wherein, all kind of substrates with diversity around aryl ring were chosen for conversion and in all cases products obtained in good to excellent yields (Table1).

According to the analysis of related databases, 139756-02-8, the application of this compound in the production field has become more and more popular.

Related Products of 151049-87-5, These common heterocyclic compound, 151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 3-bromo-1-methyl-pyrazole (156 mg) and 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl)pyridazine (200 mg) in 1 ,4-dioxane (2 ml_) was added potassium phosphate (0.5 g) and water (0.4 ml_), followed by degassing and purging with nitrogen for 10 minutes. (0700) Chloro(crotyl)(tricyclohexylphosphine)palladium(ll) (28 mg) was added and the reaction mixture was degassed once again. This mixture was heated at 1 10C under microwave irradiation for 30 minutes. After cooling to room temperature the reaction mixture was concentrated and purified by preparative reverse phase HPLC to afford 4-(1-methylpyrazol-3-yl)pyridazine as a white solid. (0701) NMR (400MHz, CD3OD) 9.77 (dd, 1 H) 9.33 (dd, 1 H) 8.41 (dd, 11-1) 7.80 (d, 1 H) 7.10 (d, 11-1) 4.04 (s, 3H)

The synthetic route of 151049-87-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 119083-00-0, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Computed Properties of C6H5F3N2O2

Example 35 N-(l-(6-(4-Fluorophenyl)-4,5-dimethylpyridazin-3-yl)piperidin-4-yl)-N,l-dimethyl-5- (trifluoromethyl)- lH-pyrazole-4-carboxamide dihydrochloride; Dissolve l-(6-(4-fluorophenyl)-4,5-dimethylpyridazin-3-yl)-N-methylpiperidin-4- amine (800 mg, 4.12 mmol) in DMF (25 mL). Add l-methyl-5-(trifluoromethyl)-lH- pyrazole-4-carboxylic acid (1.08 g, 3.44 mmol), triethylamine (1.44 mL, 10.3 mmol) and PyBOP (2.68 g, 5.15 mmol). Stir at ambient temperature for 3 h. Concentrate the reaction mixture and purify the residue by flash silica gel chromatography using a gradient of 0-100% (5: 1 EtOAc: 2 M NuEta3/MeOEta) in hexanes. Dissolve the isolated product in CH2Cl2 (10 mL) and add 2 M HCl in Et2O (8 mL). Remove solvents under a stream of N2 and dry in a vacuum oven at 50 0C overnight to afford the title compound (612 mg, 32%). ES/MS (m/z) 491.2 (M+l). Prepare the amides in the table below by essentially following the procedure described in Example 34, using the appropriate carboxylic acid. Purify Example 36 over an SCX column (eluting with 2 M NH3/MeOH) followed by flash chromatography.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 5203-77-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2.5 g (0.022 mol) of 1,3-dimethyl-5-hydroxypyrazole,40 mL of tetrahydrofuran was added to a three-necked flask,9.0 g of triethylamine (0.09 mol) was added with stirring.Ice bath control temperature of 5-10 ,A solution of 6.3 g (0.022 mol) of a solution of 2-methanesulfonyl-4-trifluoromethylbenzoyl chloride in tetrahydrofuran was added dropwise,Control the reaction temperature does not exceed 15 ,Drop finished,Remove the ice bath,The reaction was stirred at room temperature for 30 min,TLC detection reaction (ethyl acetate: petroleum ether = 4: 1, GF254, UV color)After the reaction is complete,2-methyl-2-hydroxypropanenitrile (0.2 g)Stirring slowly warming to 45-50 C reaction,TLC detection reaction (ethyl acetate: petroleum ether = 2: 1, GF254, UV color)After the reaction is complete,A solution of 5.5 g (0.023 mol) of tetrahydrofuran in 4-allyl-2-methoxyphenoxyacetyl chloride was added dropwise at room temperature,Control the temperature does not exceed 35 ,Drop at room temperature stirring 8hr,Add 50 mL of water to stir the crystals. The precipitated solid was collected by filtration and washed with 30% ethanol to give the title compound (7.2 g), yield: 57.8%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dimethyl-1H-pyrazol-5-ol, other downstream synthetic routes, hurry up and to see.

Related Products of 368870-03-5,Some common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, molecular formula is C10H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 3-(2,4-difluorophenyl)-3-oxopropanoate (UIPC-II-278)(28) (60 mg, 0.26 mmol) was refluxed in triethylorthoformate(0.110 mL, 0.65 mmol) and acetic anhydride (0.10 mL, 1.05 mmol) for 24 h to yield the intermediate enol ether (29). After the reactionwas complete, the mixture was concentrated in vacuo and thendissolved in ethanol. To this was added (4-(1H-pyrazol-1-yl)phenyl)methanamine (55 mg, 0.30 mmol) and the reaction wasallowed to stir at room temperature for 2 h. The reaction wasconcentrated in vacuo and purified by flash chromatography using agradient of dichloromethane:methanol. The reaction intermediatewas then dissolved in dioxanes, sodium hydride (13 mg,0.52 mmol) was added at 0 C and the reaction was allowed to stirfor 1 h. Once complete, the reaction was concentrated in vacuo anddiluted with water and extracted thrice with 10 mL ethyl acetate.The combined organic layers were washed with brine, dried overNa2SO4, filtered and concentrated in vacuo to afford 30b in 89%yield. 30b was used for the next step without further purification.MS ESI calculate for (M H) 392.136, found 392.13. Retention time(analytical HPLC) 18.1 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O3

(A)Methyl 5-(benzyloxy)-1-methyl-1H-pyrazole-3-carboxylateA mixture of methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (10.0 g, 64.0 mmol), benzyl bromide (12.0 g, 70 mmol) and potassium carbonate (13.8 g, 100 mmol) in N,N-dimethylformamide (150 mL) was stirred at 50¡ã C. for 16 h.Water was added to the reaction solution, and the mixture was extracted with ethyl acetate.The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to purify the residue by NH-silica gel column chromatography (hexane/ethyl acetate 90:10 to 50:50).Solvent was removed to obtain a solid (15.8 g, quant.).1H NMR (300 MHz, CDCl3) delta ppm 3.72 (s, 3H), 3.89 (s, 3H), 5.10 (s, 2H), 6.12 (s, 1H), 7.31-7.48 (m, 5H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 1572-10-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-10-7, name is 3-Amino-5-phenylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

3-Amino-5-phenyl pyrazole (477 mg) and ethyl 2-N,N-dimethylaminomethylene acetoacetate (556 mg) were dissolved in ethanol (10 ml) and stirred at 70C for 1.5 hours. The reaction mixture was added conc. hydrochloric acid (1 mg), and was stirred for additional 1 hour. The mixture was cooled to room temperature and concentrated under reduced pressure. Ethanol (10 ml) and 5 N aqueous sodium hydroxide solution (3 ml) were added to the residues and then stirred at 70C for 1 hour. After cooling to room temperature, water and ethyl acetate were added to the mixture. 2 N hydrochloric acid was added to the aqueous phase until it became acidic, and precipitated crystals were collected and washed with water and n-hexane to give 3f (463 mg, Y.: 61%) as yellow crystals.1H NMR: d 3.2 (3H, s), 7.4 (1H, s), 7.5 (3H, m), 8.1 (2H, d), 8.9 (1H, s), 13.6 (1H, brs); MS (m/z): 252 (M-H)-.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-5-phenylpyrazole. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 950858-65-8, name is 1-tert-Butyl-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C8H12N2O2

To a suspension of 5.00 g (29.7 mmol) 1-tert-butyl-1H-pyrazole-4-carboxylic acid and 5.80 g (59.5 mmol) Nu,Omicron-dimethylhydroxylamine hydrochloride in 60 ml dichloromethane are added 12.5 g (65.4 mmol) N-(3-dimethylaminopropyl)- N’-ethylcarbodiimide hydrochloride, 4.42 g (32.7 mmol) 1-hydroxybenzotriazol and 16.5 ml (119 mmol) triethylamine. The reaction mixture is stirred for 18 hours at room temperature. It is quenched with saturated sodium hydrogen carbonate solution and the mixture is partitioned between water and dichloromethane. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on a silica gel column with cyclohexane/ethyl acetate as eluent to afford 1-tert-butyl-1H-pyrazole-4- carboxylic acid methoxy-methyl-amide as colorless crystals; HPLC/MS 1.91 min (B), [M+H] 212.

The synthetic route of 950858-65-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Amino-1H-pyrazole-3-acetic acid

Preparation of (3-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)acetic acid 4-Chloro-7-(3-chloropropoxy)quinazoline was added to 1 molar equivalent of a solution of (3-amino-1H-pyrazol-5-yl)acetic acid in N-methylpyrrolidinone (NMP) and then left for a period of 12 hours. Crystallisation of the product was observed to occur with and without seeding and with and without the addition of acetonitrile as an anti-solvent. The resultant solid was isolated by filtration, washed with N-methylpyrrolidinone and acetonitrile and then dried in vacuo to yield (3-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)acetic acid.hydrochloride as an off-white solid containing one molar equivalent of NMP: 1H-NMR (DMSO d6): 8.92 (s, 1H), 8.79 (d, 1H), 7.45 (pr of d, 1H), 7.38 (d, 1H), 6.7 (s, 1H), 6.67 (s, 1H), 4.31 (t, 2H), 3.85 (t, 2H), 3.72 (s, 2H), 3.3 (t), 2.7 (s,), 2.27 (m, 2H), 2.18 (t), 1.9 (m):MS (+ve ESI): 362.1015 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.