September 2,2021 News Sources of common compounds: 51985-95-6

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H8N2O3

6. 5-Difluoromethoxy-3-methoxycarbonyl-1-methylpyrazole 67.6 g (0.43 mol) 5-Hydroxy-3-methoxycarbonyl-1-methylpyrazole and 299.2 g (2.17 mol) potassium carbonate was dissolved in 1500 ml dimethylformamide and heated to 70° C. At this temperature chlorodifluoromethane was introduced over 2 hours and the mixture stirred at 80° C. for 1.5 hours. The reaction mixture was added to water and extracted 6 times with ethyl acetate. The combined organic phases were washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The reaction solution was concentrated. Yield: 80.6 g=90.3percent of theory.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5580986; (1996); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Extracurricular laboratory: Synthetic route of 51985-95-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51985-95-6, its application will become more common.

Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H8N2O3

Example 134; (S, E)-Methyl 4-(6-(l-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-(5- methoxy-1-methyl-1H-pyrazol-3-yl)ethyl)-3-oxo-2>3-dihydropyridazin-4- yl)phenylcarbamate; 134 A. methyl 5 -methoxy-1 -methyl- 1H-pyrazole-3-carboxylate: To a cooled solution (0 °C) of methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (1.60 g, 10.25 mmol) and K2CO3 (2.124 g, 15.37 mmol) in DMF (10 mL) was added dropwise MeI (0.703 mL, 11.27 mmol). The reaction mixture was stirred under argon at rt for 5 days. The reaction mixture was diluted with EtOAc, washed with H2O (1 x 15 mL), saturated NaHCO3 (1 x 15 mL) and brine (1 x 15 mL). The organic phase was dried over MgSO^ filtered an Purification by normal phase chromatography gave 134A (1.20 g, 7.05 mmol, 68.8 percent yield) as a white solid. LC- MS (ESI) m/z: 171.2(M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51985-95-6, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/114677; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Brief introduction of C6H8N2O3

The synthetic route of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 51985-95-6

Methyl 5 -hydroxy- i-methyl- 1H-pyrazole-3 -carboxylate (I Med. Chem., 54:8174 (2011)) (0.35 g, 2.24 mmol), K2C03 (0.62 g, 4.48 mmol), and sodium chlorodifluoroacetate (0.684 g, 4.48 mmol) were dissolved in DMF (10 mL) and water (1 mL). The reaction was heated to 130 °C for 20 mm. The reaction was diluted with water (100 mL) and EtOAc (200 mL). The organic phase was separated, washed with water(5x) and brine, dried (Na2SO4) and concentrated. The residue was purified by flash chromatography (0-80percent EtOAc/Hex gradient) to give Intermediate 14A (0.3 73 g, 81percent yield) as a colorless syrup. MS(ESI) m/z: 207.0 (M+H) ?H NMR: (400 MHz, CDC13) oe ppm 6.44 (t, J=i.0 Hz, 1H), 6.46 (t, J=72.2 Hz, 1H), 3.92 (s, 3H), 3.82 (s, 3H); ?9F-NMR:(376 MHz, CDC13) oe ppm -84.02 (s, 2F).

The synthetic route of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LADZIATA, Vladimir; GLUNZ, Peter W.; HU, Zilun; WANG, Yufeng; (0 pag.)WO2016/10950; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The important role of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51985-95-6, its application will become more common.

Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H8N2O3

Intermediate 17-65 (200 mg, 1.28 mmol) and POBr3 (500 mg, 1.74 mmol) are dissolved in MeCN (30 mL) and the resulting solution is heated in a sealed flask at 80 C for 3 h. The solution is cooled down and slowly poured into saturated NaHC03 solution (50 mL) and extracted with EtOAc. The combined extracts is washed with brine, dried over MgS04 and concentrated to afford intermediate 17-66 (200 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51985-95-6, its application will become more common.

Extracurricular laboratory: Synthetic route of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

According to the analysis of related databases, 51985-95-6, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 51985-95-6

c) l-Methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-lH-pyrazole-3-carboxylic acid methyl esterTo a stirred solution of 5 -hydroxy- 1 -methyl- lH-pyrazole-3-carboxylic acid methyl ester (400 mg, 2.6 mmol) and (5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-methanol (500 mg, 2.6 mmol) inTHF(10 mL) at 5 0C under argon was added triphenylphosphine (862 mg, 3.3 mmol), then diethyl azodicarboxylate (573 mg, 3.3 mmol) was added dropwise. The reaction mixture was warmed to room temperature and stirred overnight. The reaction mixture was then evaporated. Purification by chromatography (silica, dichloromethane: methanol = 9:1) then purification using a 5 x 50 cm Chiralpak AD column at room temperature using an isopropanol:heptane (2:8) mobile phase with UV detection at 220 nM afforded the title compound (400 mg, 48percent) as a white solid. MS: m/e = 328.3 [M+H]+.

According to the analysis of related databases, 51985-95-6, the application of this compound in the production field has become more and more popular.

Analyzing the synthesis route of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O3

(A)Methyl 5-(benzyloxy)-1-methyl-1H-pyrazole-3-carboxylateA mixture of methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (10.0 g, 64.0 mmol), benzyl bromide (12.0 g, 70 mmol) and potassium carbonate (13.8 g, 100 mmol) in N,N-dimethylformamide (150 mL) was stirred at 50¡ã C. for 16 h.Water was added to the reaction solution, and the mixture was extracted with ethyl acetate.The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to purify the residue by NH-silica gel column chromatography (hexane/ethyl acetate 90:10 to 50:50).Solvent was removed to obtain a solid (15.8 g, quant.).1H NMR (300 MHz, CDCl3) delta ppm 3.72 (s, 3H), 3.89 (s, 3H), 5.10 (s, 2H), 6.12 (s, 1H), 7.31-7.48 (m, 5H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Analyzing the synthesis route of Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O3

(A)Methyl 5-(benzyloxy)-1-methyl-1H-pyrazole-3-carboxylateA mixture of methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (10.0 g, 64.0 mmol), benzyl bromide (12.0 g, 70 mmol) and potassium carbonate (13.8 g, 100 mmol) in N,N-dimethylformamide (150 mL) was stirred at 50¡ã C. for 16 h.Water was added to the reaction solution, and the mixture was extracted with ethyl acetate.The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to purify the residue by NH-silica gel column chromatography (hexane/ethyl acetate 90:10 to 50:50).Solvent was removed to obtain a solid (15.8 g, quant.).1H NMR (300 MHz, CDCl3) delta ppm 3.72 (s, 3H), 3.89 (s, 3H), 5.10 (s, 2H), 6.12 (s, 1H), 7.31-7.48 (m, 5H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Sources of common compounds: Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its application will become more common.

Synthetic Route of 51985-95-6,Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 43a) Methyl 5-hydroxy-1 -methyl-1 H-pyrazole-3-carboxylate (2.0 g) was added at 0 ¡ãC to a solution of phosphorus(V) oxychloride (13.7 g) in dry DMF (3 g) and the mixture was heated to 120 ¡ãC for 4 h. After cooling to ambient temperature the reaction was quenched by the addition of ice water (100 mL) and the suspension was stirred for 30 min. The precipitated solid formed was isolated through filtration and was washed with water to yield the desired compound (56percent yield). LC-MS (Method 2): mlz [M+H]+ = 203.2 (MW calc. = 202.60); R, = 2.3 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its application will become more common.

Brief introduction of 51985-95-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its application will become more common.

Reference of 51985-95-6,Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: To a solution of methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (2.0 g, 12.8 mmol) inCH3CN (47 mL) was added phosphorus(V)oxybromide (18.3 g, 63.8 mmol) and the mixture was heated to80 C for 18 h. The reaction mixture was chilled in an ice bath and sat. Na2CO3 solution was added. Themixture was extracted with EtOAc, the combined organic layers were dried and the volatiles wereremoved under reduced pressure to yield the desired product.LC-MS (Method 2): mlz [M+H] = 219.0 (MW calc. = 219.04); Rt = 0.45 mm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its application will become more common.

Some scientific research about 51985-95-6

The synthetic route of 51985-95-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 51985-95-6, These common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A) methyl 5-(4-((tert-butyl(dimethyl)silyl)oxy)phenoxy)-1-methyl-1H-pyrazole-3-carboxylate (1089) A mixture of 660 methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (2.68 g), 661 (4-((tert-butyl(dimethyl)silyl)oxy)phenyl)boronic acid (4.33 g), 662 copper(II) acetate (4.69 g), 121 triethylamine (3.90 ml), molecular sieves 4A (5.5 g) and 110 dichloromethane (60 ml) was stirred at room temperature for 15 hr. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate) to give the 663 title compound (600 mg). 1H NMR (400 MHz, CDCl3) delta 0.20 (6H, s), 0.99 (9H, s), 3.83 (3H, s), 3.89 (3H, s), 6.03 (1H, s), 6.75-6.86 (2H, m), 6.95-7.05 (2H, m).

The synthetic route of 51985-95-6 has been constantly updated, and we look forward to future research findings.