Category: 174891-10-2

Adding a certain compound to certain chemical reactions, such as: 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 174891-10-2, SDS of cas: 174891-10-2

mixture of 4-chloro-5-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline (2.01g, 6.34mmol), (3-amino-lH-pyrazol-5-yl)acetic acid (0.89g, 6.31mmol) and hydrogen chloride (1.6ml of a 4M solution in 1,4-dioxane, 6.4mmol) in dimethylacetamide (20ml) were stirred at room temperature for 4 hours. The resulting thick suspension was added to water (100ml) then 40% aqueous sodium hydroxide solution added to pEta 12. 2N Hydrochloric acid was then added to re-adjust the pH to 4.8. The resulting pale orange solid was filtered, washed with water and dried over phosphorus pentoxide under high vacuum to give (3-{[5-(2- chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-yl]amino}-lH-pyrazol-5-yl)acetic acid (2.45g, 92% yield). MS (+ESI): 422 (M+H+).

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Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/67391; (2006); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-Amino-1H-pyrazole-3-acetic acid

Example 100[0255] To compound 97 (700mg, 4.96mMol) in 7mL of DMF at O0C was added pyridine (883 muL, 863mg, 10.9ImMoI) followed by careful, dropwise addition of pentafluorophenyl trifluoroacetate (1.68mL, 2.78g, 9.92mMol). Reaction mixture was stirred at 0 C for 10 minutes and 90 minutes at room temperature. 2-chloro-6-methylaniline (1.22mL, 1.4g, 9.92mMol) was added and reaction mixture was stirred overnight at room temperature. Reaction was poured into 5OmL of IN HCl, organic layer was separated. Aqueous layer was extracted with EtOAc. Organic fractions were combined, washed with brine, dried over Na2SO4, filtered and solvent was evaporated to give 1.79g (quant.) of crude product 100 that was used in the next step without purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 174891-10-2.

Reference:
Patent; ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; NALLAN, Laxman; POLAT, Tulay; KORONIAK, Lukasz; DESAI, Neil; WO2010/144338; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 174891-10-2,Some common heterocyclic compound, 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

7-(Benzyloxy)-4-chloroquinazoline (1.0 g, 3.70 mmol) was dissolved in acetic acid (6 mL) and 3-amino-1H-pyrazole-5-acetic acid (0.78 g, 5.56 mmol).The temperature was raised to 100 C for 2.5 hours. The reaction was stopped, the temperature was lowered to room temperature, and after a large amount of solid was precipitated, it was filtered, and the filter cake was rinsed with a small amount of acetic acid (3 mL), and ethyl acetate (10 mL) was rinsed, and dried under vacuum at 60 C under vacuum.A pink solid (1.28 g, 92.09%) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1H-pyrazole-3-acetic acid, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Amino-1H-pyrazole-3-acetic acid

Preparation of (3-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)acetic acid 4-Chloro-7-(3-chloropropoxy)quinazoline was added to 1 molar equivalent of a solution of (3-amino-1H-pyrazol-5-yl)acetic acid in N-methylpyrrolidinone (NMP) and then left for a period of 12 hours. Crystallisation of the product was observed to occur with and without seeding and with and without the addition of acetonitrile as an anti-solvent. The resultant solid was isolated by filtration, washed with N-methylpyrrolidinone and acetonitrile and then dried in vacuo to yield (3-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)acetic acid.hydrochloride as an off-white solid containing one molar equivalent of NMP: 1H-NMR (DMSO d6): 8.92 (s, 1H), 8.79 (d, 1H), 7.45 (pr of d, 1H), 7.38 (d, 1H), 6.7 (s, 1H), 6.67 (s, 1H), 4.31 (t, 2H), 3.85 (t, 2H), 3.72 (s, 2H), 3.3 (t), 2.7 (s,), 2.27 (m, 2H), 2.18 (t), 1.9 (m):MS (+ve ESI): 362.1015 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Amino-1H-pyrazole-3-acetic acid

Preparation of (3-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)acetic acid 4-Chloro-7-(3-chloropropoxy)quinazoline was added to 1 molar equivalent of a solution of (3-amino-1H-pyrazol-5-yl)acetic acid in N-methylpyrrolidinone (NMP) and then left for a period of 12 hours. Crystallisation of the product was observed to occur with and without seeding and with and without the addition of acetonitrile as an anti-solvent. The resultant solid was isolated by filtration, washed with N-methylpyrrolidinone and acetonitrile and then dried in vacuo to yield (3-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)acetic acid.hydrochloride as an off-white solid containing one molar equivalent of NMP: 1H-NMR (DMSO d6): 8.92 (s, 1H), 8.79 (d, 1H), 7.45 (pr of d, 1H), 7.38 (d, 1H), 6.7 (s, 1H), 6.67 (s, 1H), 4.31 (t, 2H), 3.85 (t, 2H), 3.72 (s, 2H), 3.3 (t), 2.7 (s,), 2.27 (m, 2H), 2.18 (t), 1.9 (m):MS (+ve ESI): 362.1015 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 174891-10-2, Quality Control of 5-Amino-1H-pyrazole-3-acetic acid

Compound 7 (96 g, 0.395 mol, 1.0 eq.) and compound 4 (83.5 g, 0.592 mol, 1.5 eq.) were suspended in 960 mL of AcOH at 18-2O0C. The suspension was heated to 100- 1020C, and stirred for 2.5 h at this temperature. The suspension was cooled down to 18-2O0C, and filtered. Filtrate cake was washed with 50 mL of AcOH, followed by 100 mL of EtOAc. Solid was collected and dried under vacuum at 5O0C (12 h) to give 136 g of compound 10 with 96.5% HPLC purity in 98.9% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1H-pyrazole-3-acetic acid, other downstream synthetic routes, hurry up and to see.